Initiation of Fracture Repair by Bone Morphogenetic Proteins

Rudresha, A H

doi:10.1097/00003086-199810001-00008

Cited by 155 publications

(85 citation statements)

References 48 publications

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“…The non-mineralized, organic part contains collagens, glycoproteins, proteoglycans and sialoproteins that play an essential role in control of growth and differentiation of osteoblasts, osteocytes and osteoclasts and in bone remodeling [7][8][9][10]. Bone development and bone regeneration are complexly regulated processes that involve a plethora of different growth and transcription factors which coordinate the interaction of cells and matrix in response to external or internal stimuli [9,[11][12][13][14][15][16][17][18][19][20].…”

Section: Components Of Bone Tissuementioning

confidence: 99%

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Tissue engineering of bone: the reconstructive surgeon's point of view

Kneser¹,

Schaefer

Polykandriotis³

et al. 2006

J Cellular Molecular Medi

464

350

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Bone defects represent a medical and socioeconomic challenge. Different types of biomaterials are applied for reconstructive indications and receive rising interest. However, autologous bone grafts are still considered as the gold standard for reconstruction of extended bone defects. The generation of bioartificial bone tissues may help to overcome the problems related to donor site morbidity and size limitations. Tissue engineering is, according to its historic definition, an "interdisciplinary field that applies the principles of engineering and the life sciences toward the development of biological substitutes that restore, maintain, or improve tissue function". It is based on the understanding of tissue formation and regeneration and aims to rather grow new functional tissues than to build new spare parts. While reconstruction of small to moderate sized bone defects using engineered bone tissues is technically feasible, and some of the currently developed concepts may represent alternatives to autologous bone grafts for certain clinical conditions, the reconstruction of largevolume defects remains challenging. Therefore vascularization concepts gain on interest and the combination of tissue engineering approaches with flap prefabrication techniques may eventually allow application of bone-tissue substitutes grown in vivo with the advantage of minimal donor site morbidity as compared to conventional vascularized bone grafts. The scope of this review is the introduction of basic principles and different components of engineered bioartificial bone tissues with a strong focus on clinical applications in reconstructive surgery. Concepts for the induction of axial vascularization in engineered bone tissues as well as potential clinical applications are discussed in detail.

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Section: Components Of Bone Tissuementioning

confidence: 99%

“…Bone regeneration is the result of a continuous interplay between growth factors and cytokines for both initiation and regulation of the remodeling process. [7,17,21]. The majority of fractures heal well under standard conservative or surgical therapy.…”

Section: Bone Regenerationmentioning

confidence: 99%

Tissue engineering of bone: the reconstructive surgeon's point of view

Kneser¹,

Schaefer

Polykandriotis³

et al. 2006

J Cellular Molecular Medi

464

350

View full text Add to dashboard Cite

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“…A prospective trial demonstrated that treatment with 200 rads/day of radiation given over five to seven days preoperatively and for one to four days postoperatively following total hip arthroplasty was highly effective in the prevention of (22,23). In addition, BMPs and MO have also been inhibited by antibody against BMP-4 or via an antagonist noggin, which binds BMP-4 directly, inhibiting ectopic bone formation (24,25). Operative intervention for immature MO is not warranted.…”

Section: Discussionmentioning

confidence: 99%

Severe myositis ossificans in a paraplegic trauma patient: Influence in pressure sore management

Park¹

2004

J Plast Surg

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Myositis ossificans (MO) is a benign, progressive, ossifying lesion that displays a characteristic zonal histological appearance. MO traumatica is a localized form of heterotopic bone formation, associated with repetitive micro-and/or macrotrauma in the majority of cases. The importance of imaging to differentiate MO from sarcomatous change and to determine maturity of the lesion is identified because suboptimal operative intervention on immature MO inevitably results in recurrence. A severe case of MO in a 24-year-old paraplegic man with chronic bilateral greater trochanteric pressure sores is presented, and the importance of the MO in the etiology and treatment of this case is discussed. An extensive review of the literature is included and integrated.Key Words: Heterotopic ossification; Myositis ossificans; Paraplegic; Pressure sore Myosite ossifiante sévère chez un polytraumatisé paraplégique : Influence du traitement des escarres de décubitus La myosite ossifiante (MO) est une lésion progressive bénigne caractérisée par son aspect histologique circonscrit. La MO traumatique est une forme localisée de formation osseuse hétérotopique associée à un microet/ou macrotraumatisme dans la majorité des cas. L'importance de l'imagerie pour différencier la MO d'une lésion sarcomateuse et pour déter-miner la maturité de la lésion est à souligner puisqu'une intervention chirurgicale stratégique suboptimale sur une MO immature entraîne inévitablement la récurrence. Un cas sévère de MO chez un paraplégique de 24 ans présentant des escarres de décubitus trochantériennes bilatérales chroniques est présenté ici. On aborde en outre l'importance de la MO dans l'étiologie et le traitement de ce cas. L'article propose aussi une revue complète de la littérature.A 24-year-old trauma patient, paraplegic secondary to a gunshot wound at the T5 level, was referred to the Plastic Surgery Division of the McGill University Hospital Center with grade IV bilateral trochanteric pressure sores. During the investigation, the presence of severe, left-sided pelvic myositis ossificans (MO) resulting in a fixed flexion contracture of the hip was noted. The patient had severe pain and spasm on leg extension and was unable to sleep or rest in a supine position. The radiological findings were consistent with MO. It was clear that this underlying problem had to be addressed simultaneously to provide definitive treatment of the trochanteric pressure sores. A review of the literature and details of the investigation of this specific case are provided.

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“…5,20,21 BMPs, which induce MSCs to commit to the chondro/osteogenic lineage, are released from degrading bone matrix and they and their receptors are also strongly expressed by soft callus cells. 22,23 BMPs are detectable by antibody staining in cells of the soft callus as early as three days after fracture in a rabbit mandible model. 24,25 Antibody staining increased as cartilage differentiated, and by two weeks after fracture osteoblasts were stained.…”

Section: Introductionmentioning

confidence: 99%