Initiation of Protein Synthesis

Novel Tetrapeptide Inhibitors of Bacterial Protein Synthesis Produced by a Streptomyces sp.

“…Finally, the selectivity of a significant number of antibiotics, which inhibits protein synthesis in bacterial but not in eukaryotic systems, is consistent with the large differences between the translation processes in bacterial and eukaryotic cells (16)(17)(18)(19)(20).…”

“…This implies that novel inhibitors directed against these targets are likely to be effective against pathogens which have developed resistance to current inhibitors of protein synthesis. Finally, the selectivity of a significant number of antibiotics, which inhibits protein synthesis in bacterial but not in eukaryotic systems, is consistent with the large differences between the translation processes in bacterial and eukaryotic cells ( − ).…”