Initiator‐Loaded Gold Nanocages as a Light‐Induced Free‐Radical Generator for Cancer Therapy

Wang, Xiaoqiang; Gao, Fan; Zhang, Xian‐Zheng

doi:10.1002/ange.201703159

Cited by 33 publications

(26 citation statements)

References 19 publications

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“…Polymer cleavage-mediated exposure of buried ligand, 47 removal of photolabile group, 48 and photocaging group 9 Cell adhesion, 47 release and patterning, 48 and in vivo cell adhesion 9 NIR-based upconversion materials UV-cleavage of ligand, 49 molecular cage, 10 and photoisomerization 50 by NIR-based upconversion using UCNPs Cell adhesion and release, 49,50 drug delivery, 10,58 in vivo stem cell differentiation, 10 and cell polarization 58 Photothermal materials NIR-based heat generation with gold nanorods, 51 silver triangles, 53 magnetite, 54 and NIR-based nanobubble formation 55 Photothermal hyperthermia, 51,53,54 photodynamic therapy, 59,60 and cell adhesion and release 56 In situ self-assembly…”

Section: Uv-based Photolabile Materialsmentioning

confidence: 99%

“…The generated alkyl radicals impair DNA to induce the apoptosis of cancer cells. 59 In another study, Fe ion that can catalyze the generation of reactive oxygen species was used for photodynamic therapy. Upon NIR irradiation, an antiferromagnetic pyrite leads to in situ surface oxidation and maintains H 2 O 2 disproportionately to catalyze ·OH generation to enable photodynamic therapy, which is further facilitated by heat-induced Fenton process.…”

Section: Nir-controlled Photothermal and Photodynamic Therapymentioning

confidence: 99%

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Remote active control of nanoengineered materials for dynamic nanobiomedical engineering

Kim

Choi

Shin

et al. 2020

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Cells dynamically interact with native nanostructured extracellular matrix at a molecular level in vivo. Developing remotely and actively controllable nanoengineered biomaterials can manipulate and unravel complex cell-material interactions that dynamically occur in the nanoscale in vivo. In this review, we discuss emerging advances in a myriad of recent nanoengineering technologies to design remotely manipulable materials that enable dynamic nanobiomedical engineering at the molecular level. In particular, we focus on remote active stimuli, such as magnetic fields, light, in situ self-assembly, and ultrasound, to manipulate dynamic cell-material interactions in both in vitro and in vivo settings. Remote active control can be particularly appealing with targeting capability for particular locations at any prescribed time points with a degree of reversibility. The unique remote controllability enables the regulation of cellular signaling, adhesion, differentiation, and polarization; cell, drug, and gene delivery; and in situ self-assembly. These materials allow the remote control in regenerative medicine, immunotherapy, cancer therapy, and biocatalysis as well as mechanistic studies on dynamic nanoscale cell-material interactions. We also highlight current challenges in the remote active control, such as reproducibility, tissue-penetrative capability, noninvasive surgery, spatial localization, and temporal variation. Albeit remotely and actively controllable nanoengineered biomaterials are in the nascent stage of development, they can evolve into multiresponsive, reversible, and cost-effective three-dimensional systems with safe and convenient long-term control at the cell, tissue, and organ level toward clinical patient-tailorable on-demand therapy. K E Y W O R D S dynamic nanobiomedical engineering, magnetic control, nanoengineered biomaterial, photonic control, remote active control, self-assembly-based control This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Section: Uv-based Photolabile Materialsmentioning

confidence: 99%

Section: Nir-controlled Photothermal and Photodynamic Therapymentioning

confidence: 99%

Remote active control of nanoengineered materials for dynamic nanobiomedical engineering

Kim

Choi

Shin

et al. 2020

VIEW

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“…Furthermore, the NIR-region absorbance endowed by the hollow nanocage structures corresponds to the photothermal therapeutic wavelength window, which does not overlap with the light absorbing region of substances in the body such as hemoglobin, fat, and water. Since the tissue penetration of NIR light is superior to that of visible light and ultraviolet rays, it presents huge advantages when combined with hollow nanoparticles [134][135][136][137][138][139][140][141][142][143].…”

Section: Conventional Shape Control By Galvanic Replacementmentioning

confidence: 99%

Recent Advances in Nanoparticle Shape and Composition Regulation Based on Galvanic Replacement for Cancer Treatment

Shin¹,

Kang²,

Jang³

2018

Preprint

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Owing to their unique physicochemical properties, nanoparticles are used in a variety of ways in the field of cancer treatment, including imaging, drug delivery, and photothermal and photodynamic therapies. The fascinating properties of nanoparticles are determined by their size, morphology, and constituent elements, and various synthetic methods and post-synthetic techniques have been applied to control these factors. Herein, we present examples of shape and composition control through galvanic replacement, a technique that exploits redox potential differences between elements to induce spontaneous ion-exchange and highlight its specific contributions to cancer treatment applications. The present article identifies the recent advances in nanoparticle formation techniques and discusses the future outlook of the field.

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“…This kind of oxygen-independent alkyl free radicals could be generated in large amounts even in the hypoxic tumor, which show a great potential for overcoming the limitation of the oxygen-dependent therapy especially in hypoxic tumor therapy. Because of the enhanced permeability of tumor vasculature and poor lymphatic drainage in the tumor microenvironment, nanoparticles, such as the Au nanocages [13 , 14] , GuS [15] , Nb 2 C [16] were extensively utilized as carriers to deliver the alkyl free radicals for improved hypoxic tumor therapy. However, it is reported that only 0.7% of the administered nanoparticle could be delivered to a targeted solid tumor during long blood circulation [17] .…”

Section: Introductionmentioning

confidence: 99%

NIR-triggered thermo-responsive biodegradable hydrogel with combination of photothermal and thermodynamic therapy for hypoxic tumor

Sun

Liu

et al. 2020

Asian Journal of Pharmaceutical Sciences

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Hypoxia is a typical feature of solid tumors, which highly limits the application of the oxygen-dependent therapy. Also, the dense and hyperbaric tumor tissues impede the penetration of nanoparticles into the deep tumor. Thereby, we designed a novel localized injectable hydrogel combining the photothermal therapy (PTT) and the thermodynamic therapy (TDT), which is based on the generation of free radicals even in the absence of oxygen for hypoxic tumor therapy. In our study, gold nanorods (AuNRs) and 2,2′-Azobis[2-(2-imidazalin-2-yl)propane] dihydrochlaride (AIPH) were incorporated into the hydrogel networks, which were formed by the copolymerization of hydrophobic N-isopropyl acrylamide (NIPAM) and hydrophilic glycidyl methacrylate modified hyaluronic acid (HA-GMA) to fabricate an injectable and near-infrared (NIR) responsive hydrogel. The crosslinked in situ forming hydrogel could not only realize PTT upon the NIR laser irradiation, but also generate free radicals even in hypoxic condition. Meanwhile the shrink of hydrogels upon thermal could accelerate the generation of free radicals to further damage the tumors, achieving the controlled drug release on demand. The designed hydrogel with a sufficient loading capacity, excellent biocompatibility and negligible systemic toxicity could serve as a long-acting implant for NIR-triggered thermo-responsive free radical generation. The in vitro cytotoxicity result and the in vivo antitumor activity illustrated the excellent therapeutic effect of hydrogels even in the absence of oxygen. Therefore, this innovative oxygen-independent platform combining the antitumor effects of PTT and TDT would bring a new insight into hypoxic tumor therapy by the application of alkyl free radical.

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Initiator‐Loaded Gold Nanocages as a Light‐Induced Free‐Radical Generator for Cancer Therapy

Cited by 33 publications

References 19 publications

Remote active control of nanoengineered materials for dynamic nanobiomedical engineering

Remote active control of nanoengineered materials for dynamic nanobiomedical engineering

Recent Advances in Nanoparticle Shape and Composition Regulation Based on Galvanic Replacement for Cancer Treatment

NIR-triggered thermo-responsive biodegradable hydrogel with combination of photothermal and thermodynamic therapy for hypoxic tumor

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