Injectable and Degradable Poly(Oligoethylene glycol methacrylate) Hydrogels with Tunable Charge Densities as Adhesive Peptide-Free Cell Scaffolds

Bakaic, Emilia; Smeets, Niels M. B.; Badv, Maryam; Dodd, Megan; Barrigar, Owen; Siebers, Emily M.; Lawlor, Michael W.; Sheardown, Heather; Hoare, Todd

doi:10.1021/acsbiomaterials.7b00397

Cited by 26 publications

(29 citation statements)

References 59 publications

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“…The development of zwitterionic hydrogels further confirmed their potential application in wound dressing [10,11]. The dual cross-linked networks composed of anionic and cationic monomers improve the mechanical properties of hydrogels and thus find application as injectable hydrogels [12]. On the other hand, new synthetic methodologies have been introduced in the field of cell adhesion to obtain composite hydrogels incorporating cationic groups in their structure to improve flexibility as well as cell adhesion [13].…”

Section: Family Of Hydrogelsmentioning

confidence: 96%

The Advantages of Polymeric Hydrogels in Calcineurin Inhibitor Delivery

2020

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In recent years, polymeric hydrogels (PolyHy) have been extensively explored for their applications in biomedicine as biosensors, in tissue engineering, diagnostic processes, and drug release. The physical and chemical properties of PolyHy indicate their potential use in regulating drug delivery. Calcineurin inhibitors, particularly cyclosporine (CsA) and tacrolimus (TAC), are two important immunosuppressor drugs prescribed upon solid organ transplants. Although these drugs have been used since the 1970s to significantly increase the survival of transplanted organs, there are concerns regarding their undesirable side effects, primarily due to their highly variable concentrations. In fact, calcineurin inhibitors lead to acute and chronic toxicities that primarily cause adverse effects such as hypertension and nephrotoxicity. It is suggested from the evidence that the encapsulation of calcineurin inhibitors into PolyHy based on polysaccharides, specifically alginate (Alg), offers effective drug delivery with a stable immunosuppressive response at the in vitro and in vivo levels. This not only may reduce the adverse effects but also would improve the adherence of the patients by the effective preservation of drug concentrations in the therapeutic ranges.

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Section: Family Of Hydrogelsmentioning

confidence: 96%

The Advantages of Polymeric Hydrogels in Calcineurin Inhibitor Delivery

2020

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“…After that, the increase in body's temperature above polymer LCST induces a phase transition that forms a physical gel, favoring the release of the drug from the scaffold. This matching between the physiological and the gelation temperature represents a great advantage for wound healing [211][212][213]. Andrgie et al developed an injectable heparin-conjugated PNIPAAm in situ gel-forming polymer with encapsulated ibuprofen to address pain and excessive inflammation during wound healing.…”

Section: Drug Delivery Applications Of Bioengineered Thermo-responsive Scaffolds In Wound Healingmentioning

confidence: 99%

Exploration of Bioengineered Scaffolds Composed of Thermo-Responsive Polymers for Drug Delivery in Wound Healing

Henríquez

Castro-Alpízar

Lopretti-Correa

et al. 2021

IJMS

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Innate and adaptive immune responses lead to wound healing by regulating a complex series of events promoting cellular cross-talk. An inflammatory response is presented with its characteristic clinical symptoms: heat, pain, redness, and swelling. Some smart thermo-responsive polymers like chitosan, polyvinylpyrrolidone, alginate, and poly(ε-caprolactone) can be used to create biocompatible and biodegradable scaffolds. These processed thermo-responsive biomaterials possess 3D architectures similar to human structures, providing physical support for cell growth and tissue regeneration. Furthermore, these structures are used as novel drug delivery systems. Locally heated tumors above the polymer lower the critical solution temperature and can induce its conversion into a hydrophobic form by an entropy-driven process, enhancing drug release. When the thermal stimulus is gone, drug release is reduced due to the swelling of the material. As a result, these systems can contribute to the wound healing process in accelerating tissue healing, avoiding large scar tissue, regulating the inflammatory response, and protecting from bacterial infections. This paper integrates the relevant reported contributions of bioengineered scaffolds composed of smart thermo-responsive polymers for drug delivery applications in wound healing. Therefore, we present a comprehensive review that aims to demonstrate these systems’ capacity to provide spatially and temporally controlled release strategies for one or more drugs used in wound healing. In this sense, the novel manufacturing techniques of 3D printing and electrospinning are explored for the tuning of their physicochemical properties to adjust therapies according to patient convenience and reduce drug toxicity and side effects.

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“…[243] Many more examples of (acyl)hydrazone cross-linked hydrogels exist. [108,110,111,117,101,[244][245][246] As a final illustration, we can mention the hydrogels developed by Dahlmann et al for myocardial tissue engineering. They produced spontaneously contracting bio-artificial cardiac tissues by encapsulating neonatal rat heart cells in acylhydrazone cross-linked alginate-HA hydrogels containing human type I collagen.…”

Section: Imine Hydrazone and Oxime Formationmentioning

confidence: 99%

Chemical cross-linking methods for cell encapsulation in hydrogels

Echalier

Valot

Martínez

et al. 2019

Materials Today Communications

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Cell-encapsulating hydrogels are of tremendous interest in regenerative medicine. Tissue engineering relies on biomaterials able to act as artificial extracellular matrices to guide cells towards the development of new tissues. Therefore, considerable efforts have been made to design biomaterials which mimic cells' native environment, thus encouraging natural behavior. The choice of biomaterial in which cells are embedded is crucial for their survival, proliferation and differentiation. Being more stable, chemical hydrogels are preferred over physical hydrogels as cell-laden substrates. When designing chemical hydrogels, scientists must choose not only the nature of the network (synthetic and/or biopolymers) but also the type of cross-link bridging hydrogel constituents. For that purpose, numerous chemistries have been used (i) to introduce reactive functions on the hydrogel precursors and (ii) to form covalent bonds in the presence of living cells. The review will discuss the advantages and limitations of each strategy.

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Injectable and Degradable Poly(Oligoethylene glycol methacrylate) Hydrogels with Tunable Charge Densities as Adhesive Peptide-Free Cell Scaffolds

Cited by 26 publications

References 59 publications

The Advantages of Polymeric Hydrogels in Calcineurin Inhibitor Delivery

The Advantages of Polymeric Hydrogels in Calcineurin Inhibitor Delivery

Exploration of Bioengineered Scaffolds Composed of Thermo-Responsive Polymers for Drug Delivery in Wound Healing

Chemical cross-linking methods for cell encapsulation in hydrogels

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