Injectable Biomaterials in Surgery

Shafi, Bilal M.; Mery, Carlos M.; Binyamin, Gary; Knight, Joseph; Gertner, Michael

doi:10.1007/978-0-387-68113-9_114

Cited by 2 publications

(2 citation statements)

References 115 publications

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“…1,3,4 Since then, it has gained FDA approval for vascular and cardiac surgical procedure use as a sealant and hemostatic aid. 51 It has yet to receive approval or undergo extensive application to orthopedic procedures in the United States.…”

Section: Gelatin-resorcin Aldehydesmentioning

confidence: 99%

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Current State and Use of Biological Adhesives in Orthopedic Surgery

Shah¹,

Meislin²

2013

Orthopedics

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Bone and tissue adhesives are common and beneficial supplements to standard methods of musculoskeletal tissue suture repair. Knowledge and development of biologically derived or inspired adhesives useful in orthopedic surgery are rapidly advancing. Recent literature demonstrates the increased adjunct or primary use of biological adhesives in the repair of musculoskeletal soft tissues, chondral fractures, and osteochondral fractures. Adhesives offer more benefits and enhancements to tissue healing than current fixation methods afford, including improved biocompatibility, resorbability, and non-immunogenicity. Further investigation is required to determine the extent of the role that these bioadhesives can play in orthopedic surgery. The largest group of biologically derived adhesives and sealants is fibrin sealants, which include first- and second-generation commercially available fibrin sealants, autologous fibrin sealants, and variants. Other groups include gelatin-resorcin aldehydes, protein-aldehyde systems, collagen-based adhesives, polysaccharide- based adhesives, mussel adhesive proteins, and various biologically inspired or biomimetic glues. Potential uses include applications in orthopedic-related blood conservation, arthroplasty, articular cartilage disorders, sports medicine, spine surgery, trauma, and tumors. The development of an adhesive with universal application is likely unfeasible, given the unique characteristics of various musculoskeletal tissues. However, the literature demonstrates the overall underuse of adhesives and indicates the rising probability of the development of a successful variety of bioadhesives for use in orthopedic surgery. As a result of reading this article, physicians should be able to: 1. Describe the difference between adhesives and sealants. 2. Recognize fibrin adhesives commonly used in practice today and identify other biological adhesives with rising potential. 3. Analyze how fibrin sealants work relative to fibrin and fibrinogen. 4. Identify anatomical areas and techniques in which fibrin sealants are used.

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Section: Gelatin-resorcin Aldehydesmentioning

confidence: 99%

“…45 The glue is also contraindicated in children because its growth will not keep up with a child's growth. 51 The use of BioGlue in neurosurgery as a dural sealant, as per the manufacturer, is not an approved or FDA-evaluated indication. Risks of its use include hemorrhage, stroke, meningitis, and CSF leaks.…”

Section: Gelatin-resorcin Aldehydesmentioning

confidence: 99%