Injectable bone cement containing carboxymethyl cellulose microparticles as a silver delivery system able to reduce implant-associated infection risk

Jacquart, Sylvaine; Fullana, Sophie Girod; Brouillet, Fabien; Pigasse, Christel; Siadous, Robin; Fatnassi, Mohamed; Grimoud, Julien; Rey, Christian; Roques, Christine; Combes, Christèle

doi:10.1016/j.actbio.2022.04.015

Cited by 21 publications

(15 citation statements)

References 74 publications

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“…The results of our study also showed a statistically significant relationship between the use of cement and the development of SSI compared with the use of allogeneic bone. At present, bone cement loaded with antibiotics or antibacterial materials is still a research hotspot of anti-infective materials 29,30 . In the future, it is possible to reduce implant-associated infection through the improvement of materials.…”

Section: Discussionmentioning

confidence: 99%

“…At present, bone cement loaded with antibiotics or antibacterial materials is still a research hotspot of anti-infective materials. 29,30 In the future, it is possible to reduce implant-associated infection through the improvement of materials. Some previous studies 16,31 reported that hypertension and diabetes were independent risk factors in SSI after spinal metastatic tumor surgery.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Risk Factors for Postoperative Surgical Site Infection in Patients Undergoing Spinal Tumor Surgery

Xin

Cao²,

Bai

et al. 2023

Clinical Spine Surgery: A Spine Publication

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Study Design: A retrospective comparative case-control study. Objective: The aim of this study was to determine the risk factors for postoperative surgical site infection (SSI) in patients with spinal tumors requiring reoperation during the perioperative period. Summary of Background Data: SSI is a common postoperative complication of spinal surgery. The occurrence of SSI not only increases the mortality rate but prolongs the patient’s hospital stay and increases the medical cost. Methods: Included in this study were 202 patients with spinal tumors who received surgical treatment between January 2008 and December 2018, of whom 101 patients who developed SSI and underwent secondary surgery were used as the SSI group, and the other 101 patients with no SSI who were matched with the SSI group by age (±10), pathologic diagnosis (malignant/no-malignant), tumor site (C/T/L/S), surgical approach (anterior/posterior/combined), and surgical team were used as the control group. The clinical data of the 202 patients in both groups were analyzed by logistic regression modeling to identify SSI-associated risk factors. Results: Multivariate logistic regression analysis showed that the revision status (B=1.430, P=0.028), the number of spinal levels fused ≥4 (B=0.963, P=0.006), and the use of bone cement (B=0.739, P=0.046) were significantly associated with the increased risk of developing postoperative SSI. Conclusions: This study identified the revision status, the number of spinal levels fused ≥4, and the use of bone cement as independent risk factors for SSI in patients with spinal tumors who underwent reoperation during the perioperative period.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Risk Factors for Postoperative Surgical Site Infection in Patients Undergoing Spinal Tumor Surgery

Xin

Cao²,

Bai

et al. 2023

Clinical Spine Surgery: A Spine Publication

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“…Given the promising results from planktonic and adherent bacteria, the ability of SrCPC scaffolds in preventing the formation of bacterial biofilms (pre-biofilm conditions) (Figure 8) or reducing the preformed biofilms (post-biofilm conditions) (Figure 9) was also investigated, as also previously reported (Balato et al, 2019;Cara et al, 2022;Jacquart et al, 2022).…”

Section: Effect Of Bone Cements Scaffolds On Biofilm Formationsmentioning

confidence: 98%

Strontium-doped apatitic bone cements with tunable antibacterial and antibiofilm ability

Dapporto

Tavoni

Restivo

et al. 2022

Front. Bioeng. Biotechnol.

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Injectable calcium phosphate cements (CPCs) represent promising candidates for the regeneration of complex-shape bone defects, thanks to self-hardening ability, bioactive composition and nanostructure offering high specific surface area for cell attachment and conduction. Such features make CPCs also interesting for functionalization with various biomolecules, towards the generation of multifunctional devices with enhanced therapeutic ability. In particular, strontium-doped CPCs have been studied in the last years due to the intrinsic antiosteoporotic character of strontium. In this work, a SrCPC previously reported as osteointegrative and capable to modulate the fate of bone cells was enriched with hydroxyapatite nanoparticles (HA-NPs) functionalized with tetracycline (TC) to provide antibacterial activity. We found that HA-NPs functionalized with TC (NP-TC) can act as modulator of the drug release profile when embedded in SrCPCs, thus providing a sustained and tunable TC release. In vitro microbiological tests on Escherichia coli and Staphylococcus aureus strains proved effective bacteriostatic and bactericidal properties, especially for the NP-TC loaded SrCPC formulations. Overall, our results indicate that the addition of NP-TC on CPC acted as effective modulator towards a tunable drug release control in the treatment of bone infections or cancers.

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“…Cellulose hydrogels can be also used as injectable implants since they are biocompatible, biodegradable, mechanical adaptable, with great porosity, characteristics that favor drug administration [ 65 ]. This approach has been investigated for CMC as injectable bone cement, encapsulated with Ag + nanoparticles to enhance the bactericidal activity in implants, minimizing the risk of rejection [ 66 ]. A propranolol-CMC bionanocomposite hydrogel granules showed a sustained release pattern in gastrointestinal conditions [ 67 ].…”

Section: Plant-derived Polymersmentioning

confidence: 99%

Plant Polysaccharides in Engineered Pharmaceutical Gels

et al. 2022

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Hydrogels are a great ally in the pharmaceutical and biomedical areas. They have a three-dimensional polymeric structure that allows the swelling of aqueous fluids, acting as an absorbent, or encapsulating bioactive agents for controlled drug release. Interestingly, plants are a source of biogels, specifically polysaccharides, composed of sugar monomers. The crosslinking of these polymeric chains forms an architecture similar to the extracellular matrix, enhancing the biocompatibility of such materials. Moreover, the rich hydroxyl monomers promote a hydrophilic behavior for these plant-derived polysaccharide gels, enabling their biodegradability and antimicrobial effects. From an economic point of view, such biogels help the circular economy, as a green material can be obtained with a low cost of production. As regards the bio aspect, it is astonishingly attractive since the raw materials (polysaccharides from plants-cellulose, hemicelluloses, lignin, inulin, pectin, starch, guar, and cashew gums, etc.) might be produced sustainably. Such properties make viable the applications of these biogels in contact with the human body, especially incorporating drugs for controlled release. In this context, this review describes some sources of plant-derived polysaccharide gels, their biological function, main methods for extraction, remarkable applications, and properties in the health field.

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Injectable bone cement containing carboxymethyl cellulose microparticles as a silver delivery system able to reduce implant-associated infection risk

Cited by 21 publications

References 74 publications

Risk Factors for Postoperative Surgical Site Infection in Patients Undergoing Spinal Tumor Surgery

Risk Factors for Postoperative Surgical Site Infection in Patients Undergoing Spinal Tumor Surgery

Strontium-doped apatitic bone cements with tunable antibacterial and antibiofilm ability

Plant Polysaccharides in Engineered Pharmaceutical Gels

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