Injectable carboxymethyl chitosan-genipin hydrogels encapsulating tea tree oil for wound healing

Hu, Kepeng; Jia, Erna; Zhang, Qimeng; Wang, Zheng; Sun, Rongjiao; Qian, Mengao; Tan, Ying; Hu, Wanle

doi:10.1016/j.carbpol.2022.120348

Cited by 37 publications

(22 citation statements)

References 49 publications

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“…The earlier work evidenced that TTO-loaded SA/quaternary ammonium salt of CS significantly inhibited both S. aureus and E. coli but showed higher activity in S. aureus due to the breakable cell membrane [ 27 ]. Similarly, carboxymethyl-CS-genipin encapsulated TTO showed higher inhibitory activity against S. aureus (99%) than E. coli (90%) [ 62 ]. TTO incorporated CS film with significant antibacterial and antifungal activity against L. monocytogenes and Penicillium italicum , respectively [ 63 ].…”

Section: Resultsmentioning

confidence: 99%

“…On the other hand, TTO-loaded CS-TTO NEMs and SA-CS-TTO increased ABTS radical scavenging activity while increasing the concentration ( Figure 7 b). The CS-TTO increased the radical scavenging activity through the amine and phenolic group of CS and TTO strongly binding with hydroxyl (OH) and DPPH radicals [ 62 ]. The study supported that clove essential oil (CEO) loaded chitosan nanoparticle increases the DPPH radical scavenging activity more than the bare CEO [ 65 ].…”

Section: Resultsmentioning

confidence: 99%

“…Similarly, the study evidenced that subdermal implantation of CS/polyvinyl Alcohol/TTO composite film decreased the inflammatory phase and improved biocompatibility [ 12 ]. In addition, carboxymethyl-CS-genipin encapsulated TTO induced significant wound closure in rat models due to the antibacterial, antioxidant, and anti-inflammatory properties of TTO and the degradation of polymers (SA and CS) [ 62 , 66 ]. Hence, these results concluded that the combination of SA-CS-TTO could improve wound healing ability owing to their antioxidant, anti-inflammatory, and antibacterial properties.…”

Section: Resultsmentioning

confidence: 99%

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Enhancing the Antioxidant, Antibacterial, and Wound Healing Effects of Melaleuca alternifolia Oil by Microencapsulating It in Chitosan-Sodium Alginate Microspheres

2023

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In this study, antibacterial and antioxidant molecules-rich Melaleuca alternifolia oil (tea tree oil (TTO)) loaded chitosan (CS) based nanoemulsions (NEMs) were prepared and encapsulated by sodium alginate (SA) microsphere for antibacterial wound dressing. CS-TTO NEMs were prepared by oil-in-water emulsion technique, and the nanoparticle tracking analysis (NTA) confirmed that the CS-TTO NEMs had an average particle size of 89.5 nm. Further, the SA-CS-TTO microsphere was confirmed through SEM analysis with an average particle size of 0.76 ± 0.10 µm. The existence of TTO in CS NEMs and SA encapsulation was evidenced through FTIR analysis. The XRD spectrum proved the load of TTO and SA encapsulation with CS significantly decreased the crystalline properties of the CS-TTO and SA-CS-TTO microsphere. The stability of TTO was increased by the copolymer complex, as confirmed through thermal gravimetric analysis (TGA). Furthermore, TTO was released from the CS–SA complex in a sustained manner and significantly inhibited the bacterial pathogens observed under confocal laser scanning microscopy (CLSM). In addition, CS-TTO (100 µg/mL) showed antioxidant potential (>80%), thereby increasing the DPPH and ABTS free radicals scavenging ability of SA-CS-TTO microspheres. Moreover, CS and SA-CS-TTO microsphere exhibited negligible cytotoxicity and augmented the NIH3T3 cell proliferation confirmed in the in vitro scratch assay. This study concluded that the SA-CS-TTO microsphere could be an antibacterial and antioxidant wound dressing.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Enhancing the Antioxidant, Antibacterial, and Wound Healing Effects of Melaleuca alternifolia Oil by Microencapsulating It in Chitosan-Sodium Alginate Microspheres

2023

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“…However, the pure CMC film is highly swollen and unstable in the calcium chloride solution, indicating a weak interaction between CMC and Ca 2+ [ 36 ]. Therefore, other CMC crosslinkers are used, such as sodium alginate [ 36 , 37 , 38 ], oxidized sodium alginate [ 39 ], and genipin [ 40 ]. In the case of CMC/alginate, increasing crosslinking improves the degradation rate because of a larger number of hydrophilic NH 2 and COOH groups in the hydrogel matrix [ 41 ].…”

Section: Gelation Techniques Of Chitosan-based Hydrogelsmentioning

confidence: 99%

Recent Development of Functional Chitosan-Based Hydrogels for Pharmaceutical and Biomedical Applications

Taokaew

Kaewkong

Kriangkrai

2023

Gels

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Chitosan is a promising naturally derived polysaccharide to be used in hydrogel forms for pharmaceutical and biomedical applications. The multifunctional chitosan-based hydrogels have attractive properties such as the ability to encapsulate, carry, and release the drug, biocompatibility, biodegradability, and non-immunogenicity. In this review, the advanced functions of the chitosan-based hydrogels are summarized, with emphasis on fabrications and resultant properties reported in literature from the recent decade. The recent progress in the applications of drug delivery, tissue engineering, disease treatments, and biosensors are reviewed. Current challenges and future development direction of the chitosan-based hydrogels for pharmaceutical and biomedical applications are prospected.

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“…[63][64][65] This adhesive material has excellent biocompatibility, biodegradability, and hemostatic and antibacterial properties, and has been widely used in clinical applications as a hemostatic excipient. 66,67 For example, HemConTM is a hemostatic bandage approved by the Food and drug administration (FDA). Because CS contains a large number of amino groups, it can only exhibit an adhesion effect via a chemical conjugation reaction upon exposing its primary amine groups under alkaline conditions.…”

Section: Natural Adhesive Materialsmentioning

confidence: 99%

Recent advances in adhesive materials used in the biomedical field: adhesive properties, mechanism, and applications

Liu

2023

J. Mater. Chem. B

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Injectable carboxymethyl chitosan-genipin hydrogels encapsulating tea tree oil for wound healing

Cited by 37 publications

References 49 publications

Enhancing the Antioxidant, Antibacterial, and Wound Healing Effects of Melaleuca alternifolia Oil by Microencapsulating It in Chitosan-Sodium Alginate Microspheres

Enhancing the Antioxidant, Antibacterial, and Wound Healing Effects of Melaleuca alternifolia Oil by Microencapsulating It in Chitosan-Sodium Alginate Microspheres

Recent Development of Functional Chitosan-Based Hydrogels for Pharmaceutical and Biomedical Applications

Recent advances in adhesive materials used in the biomedical field: adhesive properties, mechanism, and applications

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