Injectable graphite-modified Fe<sub>3</sub>O<sub>4</sub>/calcium phosphate bone cement with enhanced heating ability for hyperthermia

Zhang, Kaili; Li, Guangda; Pei, Zhengjun; Zhao, Shuang; Jing, Aihua; Liang, Guozheng

doi:10.1080/10667857.2019.1706809

Cited by 8 publications

(10 citation statements)

References 20 publications

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“…Consequently, Ms, and anisotropy can be tuned by changing the Zn:Fe ratio, and Ms can be increased by properly doping zinc elements in ferrite [12]. Zn 0.3 Fe 2.7 O 4 nanoparticles have the highest SAR in a series of zinc-doped ferrite nanoparticles [10,11]. Previous studies have demonstrated that superparamagnetic iron oxide nanoparticles with an average size of 19 ± 3 nm had significant SAR values under clinical conditions [14].…”

Section: Discussionmentioning

confidence: 99%

“…Such a high weight ratio of magnetic nanoparticles not only affects the physicochemical properties but can also increase Life 2022, 12, 1342 2 of 14 the cytotoxicity if the bone cement matrix is degradable, such as with calcium phosphate (CPC) and calcium sulfate (CS). Previous investigations have given the reason for this as poor heating efficiency of magnetic nanoparticles [10,11]. Accordingly, improving the heating efficiency of the magnetic nanoparticles will reduce the weight ratio in the bone cement matrix, which will also minimize the effect on physicochemical properties.…”

Section: Introductionmentioning

confidence: 99%

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Feasibility Study of a Novel Magnetic Bone Cement for the Treatment of Bone Metastases

Ren

Han

et al. 2022

Life

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Bone cement is a crucial material to treat bone metastases defects, and can fill the bone defect and provide mechanical support simultaneously, but the antitumor effect is very limited. Magnetic bone cement not only supports bone metastasis defects but can also achieve magnetic hyperthermia to eliminate tumor cells around the bone defect. However, the physicochemical properties of the bone cement matrix will change if the weight ratio of the magnetic nanoparticles in the cement is too high. We mixed 1 weight percent Zn0.3Fe2.7O4 with good biocompatibility and high heating efficiency into a polymethyl methacrylate matrix to prepare magnetic bone cement, which minimized the affection for physicochemical properties and satisfied the hyperthermia requirement of the alternating magnetic field.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Feasibility Study of a Novel Magnetic Bone Cement for the Treatment of Bone Metastases

Ren

Han

et al. 2022

Life

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“…[181][182][183] Magnetic GC powders can also be included in bone cement. 71,72 BGCs can be used for both magnetic HT and photoinduced (photothermal) HT. Given the importance and great potential of the latter approach, a short description of this HT therapy is provided here for the Reader's benefit.…”

Section: Methodsmentioning

confidence: 99%

“…Besides being used as NPs, bioceramics can be embedded in bone cement, too. 71,72 These types of magnetic bioceramic cement displayed great ability to fight against cancer cells with no cytotoxicity to healthy cells. In general, GCs containing magnetic crystals are among the most studied and versatile materials in the context of HT therapy because of their exceptional properties, including good HT properties, bioactivity, and biocompatibility.…”

Section: Materials For Ht Applications: a Short Overviewmentioning

confidence: 99%

A critical review of bioceramics for magnetic hyperthermia

et al. 2021

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Hyperthermia (HT) is a rapid cancer therapy inducing cellular apoptosis by increasing the local temperature of cancerous tissues between 40 and 44°C. 1 The tumors are highly susceptible to this thermal range at which cancerous cells are destroyed, while the normal cells undergo no significant damaging effects. HT is induced by using magnetic materials under an alternating magnetic field (AMF). Benefitting from some favorable characteristics of magnetic nanomaterials (MNPs), magnetic HT has drawn enormous attention and reduced the adverse side effects related to conventional treatments of several tumors such as prostate, glioblastoma, and metastatic bone cancer. 1 This method is usually combined with other therapeutic approaches like chemotherapy (drug delivery), photothermal therapy, gene therapy, immunotherapy, and high-intensity focused ultrasound, which is critically discussed in this paper. 1 The exact process of HT is not yet fully understood since a variety of biological effects can simultaneously occur like heat-induced alteration of cells signaling pathways, DNA, and RNA alterations; expressions of heat-shock proteins; and many other biochemical changes, as well as the direct cytotoxic effect of heat. 2,3 Still, there is a theory which has been mostly accepted by scientists that the impaired vascularization of tumors, together with heat, leads to the lack of oxygen in the tumor environment. As a result, malignant cells escalate their anaerobic metabolism

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“…In the past few years, a number of papers reported the heating performance of MNPs embedded in bone cement and epoxy to mimic frozen MNPs in vivo. [45][46][47][48][49] The reported SLP values ranged from 10 W g −1 at 4 kA m −1 , 100 kHz (intrinsic loss power, ILP = 5.7 nHm 2 kg −1 ) to 122 W g −1 at 24 kA m −1 , 536.5 kHz (ILP = 0.3 nHm 2 kg −1 ). One group reported erroneously high SLP of hundreds of W g −1 ; based on the heating curves provided, the actual SLP is estimated to be less than 60 W g −1 at 5.72 kA m −1 and 626 kHz.…”

Section: Introductionmentioning

confidence: 99%

Bone Tumor Suppression in Rabbits by Hyperthermia below the Clinical Safety Limit Using Aligned Magnetic Bone Cement

Gao

et al. 2021

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composition [14,19] of MNPs. For example, we obtained an SLP of 3417 W metal g 1 − at a field of 33 kA m −1 and 380 kHz in Co 0.03 Mn 0.27 Fe 2.7 O 4 /SiO 2 MNPs. [14] In recent years, great progress has been made on in vivo magnetic hyperthermia treatments of solid tumors. [20][21][22][23][24][25][26][27] It was reported that tumors in mice can be eliminated after receiving magnetic hyperthermia treatment using coreshell MNPs. [6] Systemically delivered ZnMn-ferrite MNPs were shown to have increased the intratumoral temperature to above 42 °C in mice, which significantly inhibited prostate cancer growth. [28] More recently, studies also focused on heat-triggered drug release and highly efficient heat-induced immunotherapy instead of using heating alone. [20,24,29] In addition to injected or delivered MNPs, magnetic composite implants and magnetic scaffolds were also used for local hyperthermia. [30][31][32][33][34][35][36][37] The first magnetic hyperthermia was attempted in 1957 for metastasis in lymph nodes. [1] In 2005, the first clinical application of interstitial hyperthermia using MNPs in locally recurrent prostate cancer was reported. [38] Maier-Hauff et al. published results from a Phase I clinical study involving 14 patients with recurrent glioblastoma multiforme. [39,40] These clinical studies were performed using a commercial machine (Mag-Force MFH 300F). A roadmap for magnetic hyperthermia Demonstrating highly efficient alternating current (AC) magnetic field heating of nanoparticles in physiological environments under clinically safe field parameters has remained a great challenge, hindering clinical applications of magnetic hyperthermia. In this work, exceptionally high loss power of magnetic bone cement under the clinical safety limit of AC field parameters, incorporating direct current field-aligned soft magnetic Zn 0.3 Fe 2.7 O 4 nanoparticles with low concentration, is reported. Under an AC field of 4 kA m −1 at 430 kHz, the aligned bone cement with 0.2 wt% nanoparticles achieves a temperature increase of 30 °C in 180 s. This amounts to a specific loss power value of 327 W g g 1 1 m me et ta al l − − and an intrinsic loss power of 47 nHm 2 kg −1 , which is enhanced by 50-fold compared to randomly oriented samples. The highperformance magnetic bone cement allows for the demonstration of effective hyperthermia suppression of tumor growth in the bone marrow cavity of New Zealand White Rabbits subjected to rapid cooling due to blood circulation, and significant enhancement of survival rate.

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Injectable graphite-modified Fe₃O₄/calcium phosphate bone cement with enhanced heating ability for hyperthermia

Cited by 8 publications

References 20 publications

Feasibility Study of a Novel Magnetic Bone Cement for the Treatment of Bone Metastases

Feasibility Study of a Novel Magnetic Bone Cement for the Treatment of Bone Metastases

A critical review of bioceramics for magnetic hyperthermia

Bone Tumor Suppression in Rabbits by Hyperthermia below the Clinical Safety Limit Using Aligned Magnetic Bone Cement

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Injectable graphite-modified Fe3O4/calcium phosphate bone cement with enhanced heating ability for hyperthermia

Cited by 8 publications

References 20 publications

Feasibility Study of a Novel Magnetic Bone Cement for the Treatment of Bone Metastases

Feasibility Study of a Novel Magnetic Bone Cement for the Treatment of Bone Metastases

A critical review of bioceramics for magnetic hyperthermia

Bone Tumor Suppression in Rabbits by Hyperthermia below the Clinical Safety Limit Using Aligned Magnetic Bone Cement

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Product

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Injectable graphite-modified Fe₃O₄/calcium phosphate bone cement with enhanced heating ability for hyperthermia