Injectable Hemostat Composed of a Polyphosphate-Conjugated Hyaluronan Hydrogel

Sakoda, Megumu; Kaneko, Makoto; Ohta, Seiichi; Pan, Qi; Ichimura, Shigetoshi; Yatomi, Yutaka; Ito, Taichi

doi:10.1021/acs.biomac.8b00588

Cited by 53 publications

(46 citation statements)

References 33 publications

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“…[9,10] Particularly, some injectable hydrogels have been developed to be used as minimally invasive surgery sealants/adhesives because they can easily deliver and conform to the complex contour of tissue sites. [11][12][13][14] Despite these recent developments, there is currently a paucity of reports on the injectable hydrogel sealants/adhesives that can be detached from the adhered tissues on demand. The on-demand detachment of surgical sealants/ adhesives is important to make the materials reusable and harmless toward the surrounding tissues.…”

Section: Introductionmentioning

confidence: 99%

Injectable Self‐Healing Natural Biopolymer‐Based Hydrogel Adhesive with Thermoresponsive Reversible Adhesion for Minimally Invasive Surgery

Lei

Dai

Fan

et al. 2021

Adv Funct Materials

203

192

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Biocompatible hydrogel adhesives with multifunctional properties, including injectability, fast self-healing, and suitable on-demand detachment, are highly desired for minimally invasive procedures, but such materials are still lacking. Herein, an injectable self-healing biocompatible hydrogel adhesive with thermoresponsive reversible adhesion based on two extracellular matrix-derived biopolymers, gelatin and chondroitin sulfate, is developed to be used as a surgical adhesive for sealing or reconnecting ruptured tissues. The resulting hydrogels present good self-healing and can be conveniently injected through needles. The strong tissue adhesion at physiological temperatures originates from the Schiff base and hydrogen bonding interactions between the hydrogel and tissue that can be weakened at low temperatures, thereby easily detaching the hydrogel from the tissue in the gelation state. In vivo and ex vivo rat model show that the adhesives can effectively seal bleeding wounds and fluid leakages in the absence of sutures or staples. Specifically, a proof of concept experiment in a damaged rat liver model demonstrates the ability of the adhesives to act as a suitable laparoscopic sealant for laparoscopic surgery. Overall, the adhesive has several advantages, including low cost and ease of production and application that make it an exceptional multifunctional tissue adhesive/sealant, effective in minimally invasive surgical applications.

show abstract

Section: Introductionmentioning

confidence: 99%

Injectable Self‐Healing Natural Biopolymer‐Based Hydrogel Adhesive with Thermoresponsive Reversible Adhesion for Minimally Invasive Surgery

Lei

Dai

Fan

et al. 2021

Adv Funct Materials

203

192

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“…Energy dispersive spectroscopy analysis of C, O, and Ca elements for MSS@CaCO 3 with aspect ratio of 1:1 also confirmed the synthesis of CaCO 3 Figure 2E shows the FTIR spectra of Janus particles. Peaks at 1187-1280 and 961-1052 cm −1 , respectively, correspond to the symmetric stretching of the PO and P-O-C bonds [38] from the starch phosphate, indicating modification of MS with STMP. Typical peaks of calcite CaCO 3 were observed at 875, 848, and 712 cm −1 , while peaks at 1087 and 745 cm −1 could be assigned to vaterite CaCO 3 .…”

Section: Resultsmentioning

confidence: 99%

Self‐Propelling Janus Particles for Hemostasis in Perforating and Irregular Wounds with Massive Hemorrhage

et al. 2020

Adv Funct Materials

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Achieving rapid and safe control of perforating and irregular hemorrhage, defined as bleeding wounds with irregular external and internal wound shape, located deep within complex and covert hemorrhage sites, is vital to decrease the risk of mortality during prehospital treatments and surgical procedures. However, current hemostatic materials do not control hemorrhage effectively as their ability to access the bleeding source and coagulate blood is limited. Here, a biphasic Janus self-propelled hemostatic particle (MSS@CaCO 3) is prepared via uniaxial growth of flower-like calcium carbonate crystal (CaCO 3) on negatively-modified-microporous starch (MSS). The as-synthesized hemostatic particle (MSS@CaCO 3 T) is loaded with thrombin and powered by the internal component CaCO 3, with the collaborative use of protonated tranexamic acid. These particles are capable of traveling against the blood flow allowing them to access deep bleeding sites, inducing synergistic blood coagulation effects to effectively halt hemorrhaging. The self-propelling Janus hemostatic particle is sufficiently available in the deep bleeding sites of liver and femoral artery hemorrhage models, wherein the hemorrhage is rapidly controlled in ≈50 s and ≈3 min, respectively. To the authors' knowledge, this is the first attempt of controlling hemorrhage using Janus hemostatic particles with a self-propelling property.

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“…Biocompatibility of the composite hydrogel in vitro and in vivo was demonstrated by viability assays of three cell lines (macrophages, fibroblasts and mesothelial cells) and by intraperitoneal and subcutaneous injections. In addition, the hydrogels showed similar hemostatic effects compared to fibrin glue in a mise liver hemorrhage model ( Sakoda et al, 2018 ).…”

Section: Polysaccharide-based Hemostatic Hydrogelsmentioning

confidence: 99%

Hydrogel-Based Biomaterials Engineered from Natural-Derived Polysaccharides and Proteins for Hemostasis and Wound Healing

Jin

Liu

et al. 2021

Front. Bioeng. Biotechnol.

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Rapid and effective hemostasis is of great importance to improve the quality of treatment and save lives in emergency, surgical practice, civilian, and military settings. Traditional hemostatic materials such as tourniquets, gauze, bandages, and sponges have shown limited efficacy in the management of uncontrollable bleeding, resulting in widespread interest in the development of novel hemostatic materials and techniques. Benefiting from biocompatibility, degradability, injectability, tunable mechanical properties, and potential abilities to promote coagulation, wound healing, and anti-infection, hydrogel-based biomaterials, especially those on the basis of natural polysaccharides and proteins, have been increasingly explored in preclinical studies over the past few years. Despite the exciting research progress and initial commercial development of several hemostatic hydrogels, there is still a significant distance from the desired hemostatic effect applicable to clinical treatment. In this review, after elucidating the process of biological hemostasis, the latest progress of hydrogel biomaterials engineered from natural polysaccharides and proteins for hemostasis is discussed on the basis of comprehensive literature review. We have focused on the preparation strategies, physicochemical properties, hemostatic and wound-healing abilities of these novel biomaterials, and highlighted the challenges that needed to be addressed to achieve the transformation of laboratory research into clinical practice, and finally presented future research directions in this area.

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Injectable Hemostat Composed of a Polyphosphate-Conjugated Hyaluronan Hydrogel

Cited by 53 publications

References 33 publications

Injectable Self‐Healing Natural Biopolymer‐Based Hydrogel Adhesive with Thermoresponsive Reversible Adhesion for Minimally Invasive Surgery

Injectable Self‐Healing Natural Biopolymer‐Based Hydrogel Adhesive with Thermoresponsive Reversible Adhesion for Minimally Invasive Surgery

Self‐Propelling Janus Particles for Hemostasis in Perforating and Irregular Wounds with Massive Hemorrhage

Hydrogel-Based Biomaterials Engineered from Natural-Derived Polysaccharides and Proteins for Hemostasis and Wound Healing

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