Injectable hyaluronan-methylcellulose composite hydrogel crosslinked by polyethylene glycol for central nervous system tissue engineering

Zhuo, Fanlu; Liu, Xujie; Gao, Qin; Wang, Ying; Hu, Kun; Cai, Qiang

doi:10.1016/j.msec.2017.07.029

Cited by 39 publications

(23 citation statements)

References 49 publications

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“…For tissue engineering, cellulose as an additive or as primary scaffold material should have mechanical properties matching real tissues (Farzamfar et al 2018;Hasan et al 2018), promote porous structures for scaffolds (Hoo et al 2013), or provide anchoring sites for osteoblasts (Gouma et al 2012), and fibroblasts (Taokaew et al 2015). The most commonly used cellulose derivatives for tissue engineering include cellulose acetate (Farzamfar et al 2018), hydroxyethyl cellulose (Zulkifli et al 2017), hydroxypropyl Xie et al (2009) Cellulose cellulose (Hoo et al 2013), cellulose sulfate (Palaninathan et al 2018), carboxymethyl cellulose (Hasan et al 2018), methyl cellulose (Zhuo et al 2017), and ethyl cellulose (Mao et al 2018a).…”

Section: Tissue Engineeringmentioning

confidence: 99%

Cellulose and its derivatives: towards biomedical applications

et al. 2021

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Cellulose is the most abundant polysaccharide on Earth. It can be obtained from a vast number of sources, e.g. cell walls of wood and plants, some species of bacteria, and algae, as well as tunicates, which are the only known cellulose-containing animals. This inherent abundance naturally paves the way for discovering new applications for this versatile material. This review provides an extensive survey on cellulose and its derivatives, their structural and biochemical properties, with an overview of applications in tissue engineering, wound dressing, and drug delivery systems. Based on the available means of selecting the physical features, dimensions, and shapes, cellulose exists in the morphological forms of fiber, microfibril/nanofibril, and micro/nanocrystalline cellulose. These different cellulosic particle types arise due to the inherent diversity among the source of organic materials or due to the specific conditions of biosynthesis and processing that determine the consequent geometry and dimension of cellulosic particles. These different cellulosic particles, as building blocks, produce materials of different microstructures and properties, which are needed for numerous biomedical applications. Despite having great potential for applications in various fields, the extensive use of cellulose has been mainly limited to industrial use, with less early interest towards the biomedical field. Therefore, this review highlights recent developments in the preparation methods of cellulose and its derivatives that create novel properties benefiting appropriate biomedical applications.

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Section: Tissue Engineeringmentioning

confidence: 99%

Cellulose and its derivatives: towards biomedical applications

et al. 2021

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“…166 Methylcellulose promotes neuron regeneration through axon connections, while hyaluronan acid promotes angiogenesis and cell proliferation. 167 The bioactive materials that compose this hydrogel provided survival factors that enhanced NSC distribution and survival in the brain via CD44mediated mechanisms and inhibited apoptosis. 168 Injection of a biopolymer hydrogel, together with neural progenitor cells, into the infarct cavity after stroke was shown to significantly enhance the survival of transplanted cells and diminish inflammatory response.…”

Section: Biomaterialsmentioning

confidence: 99%

“…Injectable hydrogels composed of hyaluronan acid and methylcellulose were demonstrated to improve the survival and integration of stem cells following transplantation in stroke injury murine models [ 166 ]. Methylcellulose promotes neuron regeneration through axon connections, while hyaluronan acid promotes angiogenesis and cell proliferation [ 167 ]. The bioactive materials that compose this hydrogel provided survival factors that enhanced NSC distribution and survival in the brain via CD44-mediated mechanisms and inhibited apoptosis [ 168 ].…”

Section: Improvement Of Stem Cell Application In Ischemic Brain Injurmentioning

confidence: 99%

Optimizing Stem Cell Therapy after Ischemic Brain Injury

et al. 2020

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Stem cells have been used for regenerative and therapeutic purposes in a variety of diseases. In ischemic brain injury, preclinical studies have been promising, but have failed to translate results to clinical trials. We aimed to explore the application of stem cells after ischemic brain injury by focusing on topics such as delivery routes, regeneration efficacy, adverse effects, and <i>in vivo</i> potential optimization. PUBMED and Web of Science were searched for the latest studies examining stem cell therapy applications in ischemic brain injury, particularly after stroke or cardiac arrest, with a focus on studies addressing delivery optimization, stem cell type comparison, or translational aspects. Other studies providing further understanding or potential contributions to ischemic brain injury treatment were also included. Multiple stem cell types have been investigated in ischemic brain injury treatment, with a strong literature base in the treatment of stroke. Studies have suggested that stem cell administration after ischemic brain injury exerts paracrine effects via growth factor release, blood-brain barrier integrity protection, and allows for exosome release for ischemic injury mitigation. To date, limited studies have investigated these therapeutic mechanisms in the setting of cardiac arrest or therapeutic hypothermia. Several delivery modalities are available, each with limitations regarding invasiveness and safety outcomes. Intranasal delivery presents a potentially improved mechanism, and hypoxic conditioning offers a potential stem cell therapy optimization strategy for ischemic brain injury. The use of stem cells to treat ischemic brain injury in clinical trials is in its early phase; however, increasing preclinical evidence suggests that stem cells can contribute to the down-regulation of inflammatory phenotypes and regeneration following injury. The safety and the tolerability profile of stem cells have been confirmed, and their potent therapeutic effects make them powerful therapeutic agents for ischemic brain injury patients.

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“…A thermally responsive, shear-thinning, noncovalent scaffold can be created using a polymer blend of HA and methylcellulose (MC) [ 89 , 90 ]. In solution at 37 °C, MC forms a weak gel due to hydrophobic junctions which decrease with increasing temperature [ 91 ].…”

Section: Chemical Modifications Of Hamentioning

confidence: 99%

Hyaluronic Acid Biomaterials for Central Nervous System Regenerative Medicine

Jensen

Holloway

Stabenfeldt

2020

Cells

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Hyaluronic acid (HA) is a primary component of the brain extracellular matrix and functions through cellular receptors to regulate cell behavior within the central nervous system (CNS). These behaviors, such as migration, proliferation, differentiation, and inflammation contribute to maintenance and homeostasis of the CNS. However, such equilibrium is disrupted following injury or disease leading to significantly altered extracellular matrix milieu and cell functions. This imbalance thereby inhibits inherent homeostatic processes that support critical tissue health and functionality in the CNS. To mitigate the damage sustained by injury/disease, HA-based tissue engineering constructs have been investigated for CNS regenerative medicine applications. HA’s effectiveness in tissue healing and regeneration is primarily attributed to its impact on cell signaling and the ease of customizing chemical and mechanical properties. This review focuses on recent findings to highlight the applications of HA-based materials in CNS regenerative medicine.

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Injectable hyaluronan-methylcellulose composite hydrogel crosslinked by polyethylene glycol for central nervous system tissue engineering

Cited by 39 publications

References 49 publications

Cellulose and its derivatives: towards biomedical applications

Cellulose and its derivatives: towards biomedical applications

Optimizing Stem Cell Therapy after Ischemic Brain Injury

Hyaluronic Acid Biomaterials for Central Nervous System Regenerative Medicine

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