Injectable local anaesthetic agents for dental anaesthesia

Abstract

For success (absence of pain), low-quality evidence suggests that 4% articaine, 1:100,000 epinephrine was superior to 2% lidocaine, 1:100,000 epinephrine for root treating of posterior teeth with irreversible pulpitis, and 2% lidocaine, 1:100,000 epinephrine was superior to 4% prilocaine plain when surgical procedures/periodontal treatment was provided. Moderate-quality evidence shows that 2% lidocaine, 1:100,000 epinephrine was superior to 3% prilocaine, 0.03 IU felypressin when surgical procedures were performed.Adverse events were rare. Moderate-quality evidence shows no difference in pain on injection when 4% articaine, 1:100,000 epinephrine and 2% lidocaine, 1:100,000 epinephrine were compared, although lidocaine resulted in slightly less pain following injection.Many outcomes tested our primary objectives in simulated scenarios, although clinical alternatives may not be possible.Further studies are needed to increase the strength of the evidence. These studies should be clearly reported, have low risk of bias with adequate sample size, and provide data in a format that will allow meta-analysis. Once assessed, results of the 34 'Studies awaiting classification (full text unavailable)' may alter the conclusions of the review.

What is of interest in Endodontology? A bibliometric review of research published in the International Endodontic Journal and the Journal of Endodontics from 1980 to 2019

“…, , St George et al . , Tupyota et al . ) have been published on the topic related to anaesthetic success of inferior alveolar nerve block.…”

“…Ordinola-Zapata et al Bibliometric review of research published in two endodontic journals International Endodontic Journal, 53, 36-52, 2020 Also, to address this knowledge gap approximately, 12 systematic reviews (Brandt et al 2011, Li et al 2012, Kung et al 2015, Lapidus et al 2016, Su et al 2016, Nagendrababu et al 2018, St George et al 2018, Tupyota et al 2018 have been published on the topic related to anaesthetic success of inferior alveolar nerve block. Controversially, local anaesthesia studies did not achieve sufficient citations to be included in the list of the top most-cited 100.…”

Evaluation of student‐to‐student local anaesthesia administration at the University of Barcelona: A cross‐sectional study

“…Local anaesthetic is frequently used during dental treatments, with the objective of patients not feeling any pain, and thereby allowing the treatment to be carried out more humanely. Therefore, the ability to administer LA correctly and effectively and avoid any complications that may occur during this procedure is of utmost importance in dentistry curriculums …”

“…The vast majority of dental procedures require local anaesthesia (LA) in order to carry out painless treatments . The correct administration of local anaesthetics requires proper teaching and training programmes .…”

Novel Dimethylacetamide-Containing Formulation Improves Infraorbital Anaesthesia Efficacy in Rats with Periodontitis

“…Modern clinical practice, despite obvious success in creating new local anaesthetics (LA) as well as optimizing technologies for delivering drugs to the site of exposure, continues to experience difficulties in achieving optimal analgesic effect of LA [1]. One of the most frequent reasons for the lack of LA efficacy in dentistry is that almost always LA are administered to patients with inflammatory processes in the area of tooth pulp, periapical zone, periodontal, or alveolar region [1,2].…”