Injectable multifunctional scaffold for spinal cord repair

Conova, Lauren; Kubinski, Pamela; Jin, Ying; Vernengo, Jennifer; Neuhuber, Birgit; Fischer, Itzhak; Lowman, Anthony M.

doi:10.1109/nebc.2010.5458269

Cited by 5 publications

(4 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…At physiological temperatures, PNIPAAm homopolymer gels hold little water and show poor elastic recovery, but by combining PNIPAAm with poly(ethylene glycol) (PEG) the mechanical and swelling properties of the polymer can be tailored [83]. PNIPAAm-PEG was used by the Lowman group to deliver BDNF for repair of a partial hemisection SCI model simply by mixing the drug along with the PNIPAAm-PEG at room temperature [84]. This group also demonstrated release of bioactive BDNF and NT-3 in vitro for a period of 30 days with minimal burst release from the same type of hydrogel [85].…”

Section: Synthetic Polymersmentioning

confidence: 99%

Injectable hydrogels for central nervous system therapy

2012

View full text Add to dashboard Cite

Diseases and injuries of the central nervous system (CNS) including those in the brain, spinal cord and retina are devastating because the CNS has limited intrinsic regenerative capacity and currently available therapies are unable to provide significant functional recovery. Several promising therapies have been identified with the goal of restoring at least some of this lost function and include neuroprotective agents to stop or slow cellular degeneration, neurotrophic factors to stimulate cellular growth, neutralizing molecules to overcome the inhibitory environment at the site of injury, and stem cell transplant strategies to replace lost tissue. The delivery of these therapies to the CNS is a challenge because the blood-brain barrier limits the diffusion of molecules into the brain by traditional oral or intravenous routes. Injectable hydrogels have the capacity to overcome the challenges associated with drug delivery to the CNS, by providing a minimally invasive, localized, void-filling platform for therapeutic use. Small molecule or protein drugs can be distributed throughout the hydrogel which then acts as a depot for their sustained release at the injury site. For cell delivery, the hydrogel can reduce cell aggregation and provide an adhesive matrix for improved cell survival and integration. Additionally, by choosing a biodegradable or bioresorbable hydrogel material, the system will eventually be eliminated from the body. This review discusses both natural and synthetic injectable hydrogel materials that have been used for drug or cell delivery to the CNS including hyaluronan, methylcellulose, chitosan, poly(N-isopropylacrylamide) and Matrigel.

show abstract

Section: Synthetic Polymersmentioning

confidence: 99%

Injectable hydrogels for central nervous system therapy

2012

View full text Add to dashboard Cite

show abstract

“…The unmodified PNIPAAm has a poor elastic recovery and has less water holding capacity which is overcome by combining it with polyethylene glycol (PEG), thus, altering its physical and mechanical characteristics [130]. The PNIPAAm-PEG was experimented with by Lowman, which showed that the delivery of BDNF for repairing the partial hemisected SCI was feasible by the addition of the CNS targeting the drug to the PNIPAAmm-PEG at the room temperature in the aqueous form [131].…”

Section: Synthetic Polymersmentioning

confidence: 99%

Trends of Chitosan Based Delivery Systems in Neuroregeneration and Functional Recovery in Spinal Cord Injuries

et al. 2021

View full text Add to dashboard Cite

Spinal cord injury (SCI) is one of the most complicated nervous system injuries with challenging treatment and recovery. Regenerative biomaterials such as chitosan are being reported for their wide use in filling the cavities, deliver curative drugs, and also provide adsorption sites for transplanted stem cells. Biomaterial scaffolds utilizing chitosan have shown certain therapeutic effects on spinal cord injury repair with some limitations. Chitosan-based delivery in stem cell transplantation is another strategy that has shown decent success. Stem cells can be directed to differentiate into neurons or glia in vitro. Stem cell-based therapy, biopolymer chitosan delivery strategies, and scaffold-based therapeutic strategies have been advancing as a combinatorial approach for spinal cord injury repair. In this review, we summarize the recent progress in the treatment strategies of SCI due to the use of bioactivity of chitosan-based drug delivery systems. An emphasis on the role of chitosan in neural regeneration has also been highlighted.

show abstract

“…138 By mixing the drug with the PNIPAAm-PEG at room temperature, such materials were employed as a device to deliver BDNF for the repair of an incomplete lesion in SCI model. 139,140 Even though PLA is widely employed to design microparticles or NPs for drug delivery applications, it may also be used to develop hydrogels with specific features. As an example, PLA-PEG-PLA triblock copolymers were analyzed for the delivery of NT-3 to the injured spinal cord in rat models.…”

Section: Injectable Hydrogelsmentioning

confidence: 99%

“…138 By mixing the drug with the PNIPAAm-PEG at room temperature, such materials were employed as a device to deliver BDNF for the repair of an incomplete lesion in SCI model. 139,140…”

Section: Introductionmentioning

confidence: 99%

Hydrogels for central nervous system therapeutic strategies

Russo

Tunesi

Giordano

et al. 2015

Proc Inst Mech Eng H

View full text Add to dashboard Cite

The central nervous system shows a limited regenerative capacity, and injuries or diseases, such as those in the spinal, brain and retina, are a great problem since current therapies seem to be unable to achieve good results in terms of significant functional recovery. Different promising therapies have been suggested, the aim being to restore at least some of the lost functions. The current review deals with the use of hydrogels in developing advanced devices for central nervous system therapeutic strategies. Several approaches, involving cell-based therapy, delivery of bioactive molecules and nanoparticle-based drug delivery, will be first reviewed. Finally, some examples of injectable hydrogels for the delivery of bioactive molecules in central nervous system will be reported, and the key features as well as the basic principles in designing multifunctional devices will be described.

show abstract

Injectable multifunctional scaffold for spinal cord repair

Cited by 5 publications

References 2 publications

Injectable hydrogels for central nervous system therapy

Injectable hydrogels for central nervous system therapy

Trends of Chitosan Based Delivery Systems in Neuroregeneration and Functional Recovery in Spinal Cord Injuries

Hydrogels for central nervous system therapeutic strategies

Contact Info

Product

Resources

About