Injectable oxidized alginate/carboxylmethyl chitosan hydrogels functionalized with nanoparticles for wound repair

Ma, Lei; Tan, Yunfei; Chen, Xiangyu; Ran, Yaqin; Tong, Qiulan; Tang, Liwen; Su, Wen; Wang, Xiaoliang; Li, Xudong

doi:10.1016/j.carbpol.2022.119733

Cited by 43 publications

(29 citation statements)

References 35 publications

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“…Carboxymethyl chitosan and its derivatives have good biocompatibility, a high moisture retention ability and good viscosity, exhibiting the advantages of ideal wound dressings. 18,56 They have been widely used for wound healing due to their antimicrobial properties, effectively attenuating tissue inflammation and promoting collagen deposition. 57 A schematic illustration of the formation of carboxymethyl chitosan-(4aminophenyl)boronic acid (CMC-PBA) hydrogels was shown in Fig.…”

Section: Characteristics Of Res Nps/gelmentioning

confidence: 99%

“…11,12 Currently, most of these carriers have been designed to enhance the killing effect toward cancer cells, [13][14][15] and the concentration of polyphenol compounds determines the antioxidant and anti-inflammatory properties of polyphenols. [16][17][18][19][20][21] A low concentration of Res plays roles in ROS clearance and inflammation inhibition, whereas a high concentration of Res would promote oxidative stress. Thus, for speeding up the wound healing it is necessary to improve its biocompatibility while maintaining its anti-inflammatory and antioxidant properties.…”

Section: Introductionmentioning

confidence: 99%

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Biocompatible, bacteria-targeting resveratrol nanoparticles fabricated by Mannich molecular condensation for accelerating infected wound healing

et al. 2022

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Section: Characteristics Of Res Nps/gelmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Biocompatible, bacteria-targeting resveratrol nanoparticles fabricated by Mannich molecular condensation for accelerating infected wound healing

et al. 2022

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“…The formulation was subjected to extensive rheological testing, indicating self-healing gel properties; it was also confirmed to swell by 155% and retain 73% of moisture over 48 h. The hydrogel, biocompatible with L929 fibroblasts, was tested in vivo on rat wounds. However, since the authors compared the results only with saline as a negative control, and not with any alternative treatment options, it is impossible to draw conclusions on the relative efficacy of the developed dressing on wound healing [137].…”

Section: Agnp In Hydrogels Composed Of Alginate and Other Polymersmentioning

confidence: 99%

Alginate-Based Materials Loaded with Nanoparticles in Wound Healing

et al. 2023

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Alginate is a naturally derived polysaccharide widely applied in drug delivery, as well as regenerative medicine, tissue engineering and wound care. Due to its excellent biocompatibility, low toxicity, and the ability to absorb a high amount of exudate, it is widely used in modern wound dressings. Numerous studies indicate that alginate applied in wound care can be enhanced with the incorporation of nanoparticles, revealing additional properties beneficial in the healing process. Among the most extensively explored materials, composite dressings with alginate loaded with antimicrobial inorganic nanoparticles can be mentioned. However, other types of nanoparticles with antibiotics, growth factors, and other active ingredients are also investigated. This review article focuses on the most recent findings regarding novel alginate-based materials loaded with nanoparticles and their applicability as wound dressings, with special attention paid to the materials of potential use in the treatment of chronic wounds.

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“…In order to improve its physicochemical properties and biological effects, different functionalized CS derivatives (glycol-CS, tannic acid-CS, carboxymethyl/β-tricalcium phosphate-CS, quaternized CS-graft-polyaniline, CS-grafted-dyhidrocaffeic acid, and agarose-CS) were obtained, using various chemical pathways (alkylation, acylation, quaternization, thiolation, sulfation, graft copolymerization, etc) [ 33 , 39 , 44 , 45 ]. Moreover, by crosslinking functionalized CS derivatives using oxidized polymers, versatile hydrogels for a variety of medical purposes (cartilage repair, bone regeneration, and wound healing) were developed [ 46 , 47 , 48 , 49 , 50 , 51 , 52 ].…”

Section: Introductionmentioning

confidence: 99%

New Smart Bioactive and Biomimetic Chitosan-Based Hydrogels for Wounds Care Management

et al. 2023

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Wound management represents a continuous challenge for health systems worldwide, considering the growing incidence of wound-related comorbidities, such as diabetes, high blood pressure, obesity, and autoimmune diseases. In this context, hydrogels are considered viable options since they mimic the skin structure and promote autolysis and growth factor synthesis. Unfortunately, hydrogels are associated with several drawbacks, such as low mechanical strength and the potential toxicity of byproducts released after crosslinking reactions. To overcome these aspects, in this study new smart chitosan (CS)-based hydrogels were developed, using oxidized chitosan (oxCS) and hyaluronic acid (oxHA) as nontoxic crosslinkers. Three active product ingredients (APIs) (fusidic acid, allantoin, and coenzyme Q10), with proven biological effects, were considered for inclusion in the 3D polymer matrix. Therefore, six API-CS-oxCS/oxHA hydrogels were obtained. The presence of dynamic imino bonds in the hydrogels’ structure, which supports their self-healing and self-adapting properties, was confirmed by spectral methods. The hydrogels were characterized by SEM, swelling degree, pH, and the internal organization of the 3D matrix was studied by rheological behavior. Moreover, the cytotoxicity degree and the antimicrobial effects were also investigated. In conclusion, the developed API-CS-oxCS/oxHA hydrogels have real potential as smart materials in wound management, based on their self-healing and self-adapting properties, as well as on the benefits of APIs.

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Injectable oxidized alginate/carboxylmethyl chitosan hydrogels functionalized with nanoparticles for wound repair

Cited by 43 publications

References 35 publications

Biocompatible, bacteria-targeting resveratrol nanoparticles fabricated by Mannich molecular condensation for accelerating infected wound healing

Biocompatible, bacteria-targeting resveratrol nanoparticles fabricated by Mannich molecular condensation for accelerating infected wound healing

Alginate-Based Materials Loaded with Nanoparticles in Wound Healing

New Smart Bioactive and Biomimetic Chitosan-Based Hydrogels for Wounds Care Management

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