2012
DOI: 10.1016/j.biomaterials.2012.02.024
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Injectable PLGA porous beads cellularized by hAFSCs for cellular cardiomyoplasty

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Cited by 70 publications
(54 citation statements)
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“…Cell microcarriers in the form 48 injectable scaffolds offer a series of desirable advantages, including 49 maintaining the cell differentiated phenotype, repairing complex 50 shaped tissue defects with minimal surgical intervention, for tissue 51 engineering applications. In order to enhance the cell-surface con-52 tact area and anchoring sites for cell attachment and proliferation 53 the surface of microcarriers is often processed to produce rough, 54 multiporous and hollow structures [4][5][6]. One such porous candi-55 date is made of chitosan due to its excellent ability to be processed 56 into porous structures by freeze-drying acid solutions [7].…”
mentioning
confidence: 99%
“…Cell microcarriers in the form 48 injectable scaffolds offer a series of desirable advantages, including 49 maintaining the cell differentiated phenotype, repairing complex 50 shaped tissue defects with minimal surgical intervention, for tissue 51 engineering applications. In order to enhance the cell-surface con-52 tact area and anchoring sites for cell attachment and proliferation 53 the surface of microcarriers is often processed to produce rough, 54 multiporous and hollow structures [4][5][6]. One such porous candi-55 date is made of chitosan due to its excellent ability to be processed 56 into porous structures by freeze-drying acid solutions [7].…”
mentioning
confidence: 99%
“…The efficacy of these systems was tested in a rat MI model, showing that animals treated with SCs-MPs had a significantly increased capillary density and positive remodeling, which resulted in an improved cardiac function 4 weeks after treatment compared to other groups. SCs were clearly retained at the site of injection and were differentiated towards cardiomyogenic and angiogenic lineages [110]. In another study, Penna C. et al demonstrated that PLGA-MP enhanced MSC survival and regeneration in the hostile environment of post-ischemic tissues [109].…”
Section: Nano/microparticles In Cell-based Therapiesmentioning
confidence: 96%
“…Poly(lactic‐co‐glycolic acid) (PLGA) is a copolymer,8 which possesses excellent biodegradability and biocompatibility properties because its ester linkages easily participate in hydrolysis, producing lactic acid, glycolic acid, and original monomers, which are nontoxic and easily metabolized through the krebs cycle in the body; moreover, the PLGA‐based microspheres have high stability, high structural integrity, tunable properties, and surface functionalization 8, 9. All of these characteristics allow its broad use in delivery systems.…”
Section: Introductionmentioning
confidence: 99%