Injectable thermosensitive PEG–PCL–PEG hydrogel/acellular bone matrix composite for bone regeneration in cranial defects

Injectable hyaluronic acid/PEG-p(HPMAm-lac)-based hydrogels dually cross-linked by thermal gelling and Michael addition

“…Dilution of the stock leachables (100%) was performed to vary the concentrations (100%, 50%, 25%) in culture medium. [40] BMSCs and NIH 3T3 cells were plated at a density of 5,000 cells/well in 96 wells culture dishes and at the density of 15,000 cells/cm 2 , in 6 wells culture dishes, and incubated with the leachables of different concentrations (0%, 25%, 50%, 100%) up to 21 days. BMSCs and NIH 3T3 cells plated at the same density and incubated in culture meium were taken as control.…”

Effects of bevacizumab loaded PEG-PCL-PEG hydrogel intracameral application on intraocular pressure after glaucoma filtration surgery

“…In our previous study, we successfully synthesized a new kind of biodegradable and injectable PEG-PCL-PEG hydrogel for developing controlled drug delivery systems, which ring-opened copolymerization of e-CL on MPEG and coupled with HMDI [11]. Due to the integration of respective advantages of PEG and PCL, PECE copolymer could have wider applications in the biomedical field, such as in inhibiting tumor growth [31], preventing the post-surgical abdominal adhesions [12] and bone regeneration [32]. Additionally, compared to Pluronic, PECE copolymer is biodegradable, and its formed hydrogel could sustain a longer time, which are very important and useful for its application in biomedical field.…”

Production and Characterisation of PCL/ES Scaffolds for Bone Tissue Engineering

“…In spite of its excellent properties, they may be improved with the combination of other material(s) [8]. Composites represent the optimal solution in agreement with the restrictive requirements of bone regeneration by taking advantage of specific properties of the constituent's compounds [4,9]. Ding et al [10] successfully produced PCL/HA composites to regenerate a goat's femoral head and observed that the addition of different materials was an added value for the success of bone regeneration.…”

“…Over the last few years, a range of biomaterials have been investigated to be applied in bone substitutions [4,5]. Poly(ε-caprolactone) is one of the reported biomaterials for this purpose, owing to its biodegradability, biocompatibility, nontoxicity and mechanical properties [6,7].…”