Injection Molding Process Simulation of Polycaprolactone Sticks for Further 3D Printing of Medical Implants

Formas, Krzysztof; Kurowska, Anna; Janusz, J.; Szczygieł, Piotr; Rajzer, I.

doi:10.3390/ma15207295

Cited by 7 publications

(4 citation statements)

References 22 publications

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“…A series of injection molding experiments were performed to evaluate the influence of the processing parameters on the quality of the polymer sticks. Furthermore, injection molding simulation using SolidWorks plastic software (29.3.0.0059, Dassault Systemes, Paris, France) was performed [ 28 ]. The injection molding parameters are presented in Table 1 .…”

Section: Methodsmentioning

confidence: 99%

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3D-Printed Polycaprolactone Implants Modified with Bioglass and Zn-Doped Bioglass

et al. 2023

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In this work, composite filaments in the form of sticks and 3D-printed scaffolds were investigated as a future component of an osteochondral implant. The first part of the work focused on the development of a filament modified with bioglass (BG) and Zn-doped BG obtained by injection molding. The main outcome was the manufacture of bioactive, strong, and flexible filament sticks of the required length, diameter, and properties. Then, sticks were used for scaffold production. We investigated the effect of bioglass addition on the samples mechanical and biological properties. The samples were analyzed by scanning electron microscopy, optical microscopy, infrared spectroscopy, and microtomography. The effect of bioglass addition on changes in the SBF mineralization process and cell morphology was evaluated. The presence of a spatial microstructure within the scaffolds affects their mechanical properties by reducing them. The tensile strength of the scaffolds compared to filaments was lower by 58–61%. In vitro mineralization experiments showed that apatite formed on scaffolds modified with BG after 7 days of immersion in SBF. Scaffold with Zn-doped BG showed a retarded apatite formation. Innovative 3D-printing filaments containing bioglasses have been successfully applied to print bioactive scaffolds with the surface suitable for cell attachment and proliferation.

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Section: Methodsmentioning

confidence: 99%

“…Recently, we were successful in developing pure PCL filament sticks using injection molding and successfully used them for FDM [ 28 ]. As a further improvement, we produced composite filaments made of a PCL matrix with 0.5, 5, 10 percentages of graphene as a filler [ 29 , 30 ].…”

Section: Introductionmentioning

confidence: 99%

3D-Printed Polycaprolactone Implants Modified with Bioglass and Zn-Doped Bioglass

et al. 2023

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“…Poly(ε-caprolactone) (PCL) is a biocompatible polymer that has been approved by the U.S. Food and Drug Administration (FDA) for clinical use. Poly(ε-caprolactone) is widely applied in long-term surgical implants − and slow-releasing drug-delivery systems − due to its biocompatibility, biodegradability, and suitable mechanical properties. In tissue engineering, PCL has been studied for applications that require slowly degrading materials, for example, guided bone regeneration − and vascular grafts. − Researchers have also explored ways to modify PCL to increase its degradation rate. , One approach is to make copolymers or to blend PCL with other polymers, such as polylactic acid, − poly( N -(2-hydroxypropyl)methacrylamide), alginate, , starch, , and zein .…”

Section: Introductionmentioning

confidence: 99%

Modified Poly(ε-caprolactone) with Tunable Degradability and Improved Biofunctionality for Regenerative Medicine

et al. 2023

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The use of poly(ε-caprolactone) (PCL) for biomedical applications is well established, particularly for permanent implants, due to its slow degradation rate, suitable mechanical properties, and biocompatibility. However, the slow degradation rate of PCL limits its application for short-term and temporary biomedical applications where bioabsorbability is required. To enhance the properties of PCL and to expand its biomedical applications, we developed an approach to produce PCL membranes with tunable degradation rates, mechanical properties, and biofunctional features. Specifically, we utilized electrospinning to create fibrous PCL membranes, which were then chemically modified using potassium permanganate to alter their degradability while having minimal impact on their fibrous morphology. The effects of the chemical treatments were investigated by treating the samples for different time periods ranging from 6 to 48 h. After the 48 h treatment, the membrane degraded by losing 25% of its mass over 12 weeks in degradation studies, while maintaining its mechanical strength and exhibiting superior biofunctional features. Our results suggest that this approach for developing PCL with tailored properties could have significant potential for a range of biomedical applications.

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“…Then, the organic binders embedded in the molds are removed via thermal pyrolysis or solvent detracting before sintering 26 . Injection molding is suitable for making relatively fine ceramic parts because it offers dimensional reproducibility, requires little or no modification, and produces parts with a sufficient quality for clinical applications 27 . In particular, this technique allows the mass production of ceramic parts at low cost and near-net-shape formation 28 .…”

Section: Introductionmentioning

confidence: 99%

Comparison between bone–implant interfaces of microtopographically modified zirconia and titanium implants

Thu

Kang²,

Kwak

et al. 2023

Sci Rep

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The aim of this study was to investigate the surface characteristics and evaluate the bone–implant interfaces of injection molded zirconia implants with or without surface treatment and compare them with those of conventional titanium implants. Four different zirconia and titanium implant groups (n = 14 for each group) were prepared: injection-molded zirconia implants without surface treatment (IM ZrO2); injection-molded zirconia implants with surface treatment via sandblasting (IM ZrO2-S); turned titanium implants (Ti-turned); and titanium implants with surface treatments via sandblasting with large-grit particles and acid-etching (Ti-SLA). Scanning electron microscopy, confocal laser scanning microscopy, and energy dispersive spectroscopy were used to assess the surface characteristics of the implant specimens. Eight rabbits were used, and four implants from each group were placed into the tibiae of each rabbit. Bone-to-implant contact (BIC) and bone area (BA) were measured to evaluate the bone response after 10-day and 28-day healing periods. One-way analysis of variance with Tukey’s pairwise comparison was used to find any significant differences. The significance level was set at α = 0.05. Surface physical analysis showed that Ti-SLA had the highest surface roughness, followed by IM ZrO2-S, IM ZrO2, and Ti-turned. There were no statistically significant differences (p > 0.05) in BIC and BA among the different groups according to the histomorphometric analysis. This study suggests that injection-molded zirconia implants are reliable and predictable alternatives to titanium implants for future clinical applications.

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Injection Molding Process Simulation of Polycaprolactone Sticks for Further 3D Printing of Medical Implants

Cited by 7 publications

References 22 publications

3D-Printed Polycaprolactone Implants Modified with Bioglass and Zn-Doped Bioglass

3D-Printed Polycaprolactone Implants Modified with Bioglass and Zn-Doped Bioglass

Modified Poly(ε-caprolactone) with Tunable Degradability and Improved Biofunctionality for Regenerative Medicine

Comparison between bone–implant interfaces of microtopographically modified zirconia and titanium implants

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