HIGHLIGHTS• Tremendous progress has been advanced by research into graphene and its derivatives with great benefits toward low-cost, portable, and real-time tactile sensors/electronic skin.• The review presented herein direct future efforts aimed at high-quality graphene-based tactile sensors and their implications for the wider scientific community.• The paper also are informative regarding some basic and crucial issues regarding graphene and its derivatives, such as charge-transport principles, doping/trapping behaviors, correlations between structure/morphology and properties/functions.ABSTRACT Skin is the largest organ of the human body and can perceive and respond to complex environmental stimulations. Recently, the development of electronic skin (E-skin) for the mimicry of the human sensory system has drawn great attention due to its potential applications in wearable human health monitoring and care systems, advanced robotics, artificial intelligence, and human-of graphene materials; (2) state-of-the-art protocols recently developed for high-performance tactile sensing, including representative examples; and (3) perspectives and current challenges for graphene-based tactile sensors in E-skin applications. A summary of these cutting-edge developments intends to provide readers with a deep understanding of the future design of high-quality tactile sensing devices and paves a path for their future commercial applications in the field of E-skin.