Inkjet-printed gold nanoparticle electrochemical arrays on plastic. Application to immunodetection of a cancer biomarker protein

Jensen, Gary C.; Krause, Colleen E.; Sotzing, Gregory A.; Rusling, James F.

doi:10.1039/c0cp01755h

Cited by 141 publications

(120 citation statements)

References 43 publications

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“…Inkjet-printed AuNP arrays were fabricated and applied to the detection of IL-6 in serum (Jensen et al, 2011). The AuNP ink was printed on a flexible, heat resistant polyimide Kapton substrate and subsequently sintered to create eight-electrode arrays costing less than $0.25 per array.…”

Section: Ajbbmentioning

confidence: 99%

Detection of Cancer Biomarkers With Nanotechnology

Zhang

et al. 2013

American Journal of Biochemistry and Biotechnology

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Early detection of cancer biomarkers with high precision is critically important for cancer therapy. A variety of sensors based on different nanostructured materials have attracted intensive research interest due to their potential for highly sensitive and selective detection of cancer biomarkers. This review covers the use of a variety of nanostructured materials, including carbon nanotubes, silicon nanowires, gold nanoparticles and quantum dots, in the fabrication of sensors. Emphases are placed on how the detection systems work and what detection limits can be achieved. Some assays described in this review outperform established methods for cancer biomarker detection. It is highly promising that these sensors would soon move into commercial-scale production and find routine use in hospitals.

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Section: Ajbbmentioning

confidence: 99%

Detection of Cancer Biomarkers With Nanotechnology

Zhang

et al. 2013

American Journal of Biochemistry and Biotechnology

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“…In the future, it might be possible to apply all AuNPs properties together and evolve new chemistry for synthesis of smart materials for diagnostic applications and clinical trials. (Jensen et al, 2011) 13 nm spherical Alkaline phosphatase; poly (styrene-co-acrylic acid); TNF-α antibody…”

Section: Gold Nanocarriers In Cancer Diagnosismentioning

confidence: 99%

Multifunctional Gold Nanocarriers for Cancer Theranostics: From Bench to Bedside and Back Again?

Conde

Tian²,

Baptista

et al. 2014

Nano-Oncologicals

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After a quarter of century of rapid technological advances, research has revealed the complexity of cancer, a disease intimately related to the dynamic transformation of the genome. However, the full understanding of the molecular onset of this disease is still far from achieved and the search for mechanisms of treatment will follow closely.It is here that Nanotechnology enters the fray offering a wealth of tools to diagnose and treat cancer.It is indisputable that the use of gold nanocarriers has been gaining momentum as vectors for therapy and diagnostic strategies, combining the AuNPs' ease of functionalization with numerous biomolecules, high loading capacity and fast uptake by target cells. In fact, over the last decade nearly 12.000 research papers focusing on multifunctional gold nanocarriers have been published in peer-reviewed journals. Some of the described nanosystems will most likely revolutionize our understanding of biological mechanisms and push forward the clinical practice through their 2 integration in future diagnostics platforms. Nevertheless, very little gave fruitful results in order to improve a bench-to-bedside approach to translational research. On the basis of theoretical and experimental results obtained so far are we or not at the point: from bench to bedside and back again? As you will see, the answers to this question are complex, but one thing is clear: Translation into clinics is a tortuous and difficult path. Here, we provide a critical review about the available multifunctional gold nanocarriers for in vitro application and in vivo cancer targeting on nanodiagnostics and therapy.

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“…Moreover, IJP can reduce the overall fabrication time and costs of an entire device due to the possibility of rapid iterative design changes during the sensor development stage and due to the up-scalability of the production rate from the prototype to the industrial level. In this way, IJP has been used for the fabrication of a broad range of chemical sensors based on gold on paper [39][40][41] as well as polymer substrates [27,42,43], silver [30,44] polyaniline [45,46] or CNTs [47][48][49][50]. CNTs are attractive functional materials for sensing platforms due to several advantageous CNT properties, such as good electrical conductivity, chemical and mechanical stability, high flexibility, electrocatalytic activity and reduced surface fouling characteristics for specific applications [51][52][53][54].…”

Section: Introductionmentioning

confidence: 99%

Inkjet-printed microtiter plates for portable electrochemical immunoassays

Jović

Zhu

Lesch

et al. 2017

Journal of Electroanalytical Chemistry

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Herein, we present the large-scale fabrication of multiplexed three-electrode sensors used in a point-of-care device platform that couples a magnetic bead-based immunoassay strategy with amperometric detection for rapid and highly sensitive analysis. The multiplexed sensors consisted of eight independent electrochemical cells, each with a carbon nanotube (CNT) working electrode, CNT counter electrode and a silver-silver chloride quasi-reference electrode. The microchips were fabricated on flexible polyethylene terephthalate (PET) sheets by sequential multilayer inkjet printing (IJP) of silver, CNT and insulator inks that were either simultaneously or subsequently post-processed (e.g. through UV photo-polymerization or photonic curing). Finally, plastic wells were mounted on top of the inkjet-printed patterns to obtain an eight-well microtiter plate where each well had a solution capacity of 50 μL. Due to the high precision of the IJP process, the microtiter plates showed high reproducibility among the individual electrochemical cells (1-2% of deviation). Furthermore, the microchips can be reusable for at least up to 20 times as demonstrated herein. In a customized multichannel potentiostat with eight implemented magnets matching the positions of the working electrodes, the electrochemical readout of magnetic bead based sandwich and competitive immunoassays was successfully realized for the detection of thyroid-stimulating hormone (TSH) and atrazine (ATR) in aqueous and urine samples, respectively. The achieved limits of detection for ATR (i.e. 0.01 μg/L) and TSH (i.e. 0.5 μIU/mL) demonstrated the potential of the IJP microtiter plates for the environmental and biological quantification of analytes in a very reliable high throughput platform. This work shows that IJP has certainly reached the status of a batch production tool for electroanalytical sensing platforms.

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Inkjet-printed gold nanoparticle electrochemical arrays on plastic. Application to immunodetection of a cancer biomarker protein

Cited by 141 publications

References 43 publications

Detection of Cancer Biomarkers With Nanotechnology

Detection of Cancer Biomarkers With Nanotechnology

Multifunctional Gold Nanocarriers for Cancer Theranostics: From Bench to Bedside and Back Again?

Inkjet-printed microtiter plates for portable electrochemical immunoassays

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