Inmunomodulación de Uncaria tomentosa sobre células dendríticas, IL-12 y perfil TH1/TH2/TH17 en cáncer de mama

Núñez, César; Lozada-Requena, Iván; Tindara, Ysmodes; Zegarra, Daniel; Saldaña, Fatima; Aguilar, José

doi:10.17843/rpmesp.2015.324.1753

Cited by 3 publications

(2 citation statements)

References 27 publications

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“…Furthermore, extracts of Uncaria showed a reduction in glycemic levels in mice and rat models [32,33]. Also, Uncaria POAs can affect the immune system [33,38,42,43], but whether this effect on immunity might possibly impact upon glucose regulation is unknown.…”

Section: Discussionmentioning

confidence: 99%

Stevia and Uncaria extract (GlucoMedix®) reduces glucose levels and the need for medications in type 2 diabetes: an open label case series of six patients

Dooley¹,

Pérez²,

Rodríquez

2022

Clin Phytosci

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Background GlucoMedix® is an all-natural phytotherapy consisting of a hydro-alcoholic extract of Stevia rebaudiana (Bertoni) Bertoni and pentacyclic chemotype Uncaria tomentosa (Willd. Ex Schult.) DC. The nutraceutical product has potential for the treatment of hyperglycemia in type 2 diabetes and Metabolic Syndrome. Methods Six adult Hispanic type 2 diabetic patients were included in an outpatient retrospective open label physician-sponsored case series study. GlucoMedix® extract of Stevia plus pentacyclic chemotype Uncaria was administered orally at doses of 2 ml, diluted in water, two or three times daily. The patients’ blood glucose levels were recorded historically, at baseline, and thereafter while taking GlucoMedix® orally. Results When treated with GlucoMedix®, with or without coincident advice to modify diet, all six patients manifested reductions in blood glucose levels. At baseline four of the six patients were administering one or more prescription treatments for hyperglycemia, e.g., Glibenclamide, Metformin, Vildagliptin, or Insulin. Two patients displayed substantial reductions in glucose of 50 and 70 mg/dl, and in conjunction with the removal of their prior drug treatments of Glibenclamide plus Metformin or of Vildagliptin. An Insulin-treated patient experienced a 50 mg/dl reduction while ceasing Metformin and was subsequently able to reduce the dose of Insulin by half. Thus, in three patients GlucoMedix® abrogated in whole or in part the requirement for pharmaceutical or biologic therapies to achieve substantial beneficial reductions in glycemic levels. Conclusions In this proof-of-principle study oral GlucoMedix® was an effective treatment for hyperglycemia in type 2 diabetic individuals. This all-natural phytotherapy can be used beneficially in conjunction with existing pharmaceutical or biological therapy regimens, and in some cases can replace in whole or in part the requirement for pharmaceutical or biologic therapies. These in-life results suggest that this natural product approach can serve as an alternative to prescription monotherapies or multimodal therapies for the regulation of hyperglycemia.

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Section: Discussionmentioning

confidence: 99%

Stevia and Uncaria extract (GlucoMedix®) reduces glucose levels and the need for medications in type 2 diabetes: an open label case series of six patients

Dooley¹,

Pérez²,

Rodríquez

2022

Clin Phytosci

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“…Investigaciones demuestran la actividad inmunomoduladores de un extracto hidroalcohólico de Uncaria en concentraciones de 500 -1 000 µg/ mL UG-POA tiene un efecto positivo sobre la respuesta inmune antitumoral y se lo categoriza como un producto natural promisorio para el uso preventivo en terapias anticancerígenas. También se ha demostrado que el alcaloide oxindólicos pentacíclicos de Uncaria tomentosa incrementa la producción de citoquinas relacionadas con la respuesta antitumoral (Núñez et al, 2015). En pruebas practicadas a personas con extracto acuoso liofilizado de corteza de uña de gato se dio un efecto en el incremento de leucocitos, así mismo se produjo un aumento en la respuesta inmunológica consiguiendo elevar la relación linfocitos/neutrófilos en la sangre (Lamm et al, 2001), un caso evidente sobre la actividad inmunoestimulantes que posee la uña de gato, se observó al aplicar 12 mg de extracto alcaloides (oxindol pentacíclicos) durante un período de 2.2 a 5 meses en pacientes con infección HIV, logrando un incremento de leucocitos (Roseel, 1996).…”

Section: Cinnamomum Zeylanicum (Canela)unclassified

Especies con características funcionales y medicinales de la agrobiodiversidad de la Amazonia ecuatoriana

Caicedo-Vargas

Paredes-Andrade²,

Rosado

et al. 2021

Orinoquia

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En la actualidad, las exigencias de los consumidores están enfocados en la búsqueda de nuevos productos con propiedades funcionales y medicinales que puedan proporcionar un valor nutritivo y otros componentes importantes que favorecen a la salud. En este contexto, estos alimentos están evolucionando como una estrategia potencial en la prevención de enfermedades crónicas porque tienen efectos beneficiosos fisiológicos, debido a que poseen compuestos bioactivos relacionados con propiedades analgésicas, antiinflamatorias, anticancerígenas, antidiabéticas, hepatoprotectoras, nefrógenas y antioxidantes; éstos componentes están contenidos en diversas plantas de los cultivos de la agrobiodiversidad de la Amazonía ecuatoriana. El objetivo de este estudio fue identificar especies vegetales con características funcionales y medicinales que contribuyan a mejorar el sistema inmunológico, para lo cual se realizó una revisión sistemática de la literatura disponible en plataformas digitales, lo que permitió identificar 15 especies con características funcionales y medicinales por sus propiedades antioxidantes, inmunoestimulantes, antiinflamatorias, antioxidantes, antivirales, antimicrobianas, antifúngicas, y anticancerígenas. Estas especies constituyen una alternativa potencial para aportar el sistema inmunológico.

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GlucoMedix®, an extract of Stevia rebaudiana and Uncaria tomentosa, reduces hyperglycemia, hyperlipidemia, and hypertension in rat models without toxicity: a treatment for metabolic syndrome

Villegas

Ascencios

Dooley³

2022

BMC Complement Med Ther

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Background The objective of this in vivo study is to evaluate in five rat models the pharmacologic effects and toxicity of a commercial hydro-alcoholic extract, GlucoMedix®, derived from Stevia rebaudiana and the pentacyclic chemotype of Uncaria Tomentosa (Willd.) DC, for use as a treatment for metabolic syndrome. The extract contains phytochemicals of Stevia (e.g., steviol glycosides) and Uncaria (e.g., pentacyclic oxindole alkaloids, but lacks tetracyclic oxindole alkaloids). Methods The pharmacologic assessments in three rat models include reductions in chemically induced hyperglycemia, hyperlipidemia (cholesterol and triglycerides), and hypertension, all of which are comorbidities of metabolic syndrome. Acute toxicity and 28-day subacute toxicity were assessed in rat models at doses higher than those used in the efficacy models. Results The acute oral toxicity was evaluated in Holtzman rats and the extract did not produce acute toxic effects or lethality, with the LD50 > 5000 mg/kg (extract wet weight). Furthermore, subacute oral toxicity was evaluated in rats for 28 days at daily doses as high as 2000 mg/kg without toxicity or abnormal clinical chemistry or hematological effects. Daily oral doses of 250 - 1000 mg/kg were used to evaluate the treatment effects in hyperglycemic (alloxan-induced and glibenclamide-controlled), hyperlipidemic (cholesterol-induced and atorvastatin-controlled), and hypertensive (L-NAME-induced and enalapril-controlled) rat models. Alloxan-induced hyperglycemia was reduced in a dose-dependent manner within 28 days or less. Cholesterol-induced hyperlipidemic rats exhibited dose-dependent reductions in cholesterol and triglycerides at 21 days. Furthermore, GlucoMedix® produced a dose-dependent decrease in systolic and diastolic arterial blood pressure in L-NAME-induced hypertensive rats at 28 days. Conclusions The five in vivo rat models revealed that the all-natural phytotherapy GlucoMedix® is a safe and effective treatment for hyperglycemia, hyperlipidemia, and hypertension. This extract is expected to affect multiple comorbidities of metabolic syndrome, without any acute or subacute oral toxicity in humans. Although multiple prescription drugs are well known for the treatment of individual comorbidities of metabolic syndrome, no drug monotherapy concurrently treats all three comorbidities.

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Inmunomodulación de Uncaria tomentosa sobre células dendríticas, IL-12 y perfil TH1/TH2/TH17 en cáncer de mama

Cited by 3 publications

References 27 publications

Stevia and Uncaria extract (GlucoMedix®) reduces glucose levels and the need for medications in type 2 diabetes: an open label case series of six patients

Stevia and Uncaria extract (GlucoMedix®) reduces glucose levels and the need for medications in type 2 diabetes: an open label case series of six patients

Especies con características funcionales y medicinales de la agrobiodiversidad de la Amazonia ecuatoriana

GlucoMedix®, an extract of Stevia rebaudiana and Uncaria tomentosa, reduces hyperglycemia, hyperlipidemia, and hypertension in rat models without toxicity: a treatment for metabolic syndrome

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