Innate and Acquired Resistance to Amebiasis in Bangladeshi Children

Haque, Rashidul; Duggal, Priya; Ali, Ibnekarim M.; Hossain, Mohammad Bakthiar; Mondal, Dinesh; Sack, R. Bradley; Farr, Barry M.; Beaty, Terri H.; Petri, William A.

doi:10.1086/341566

Cited by 144 publications

(143 citation statements)

References 36 publications

Supporting

Mentioning

129

Contrasting

Unclassified

Order By: Relevance

“…A higher lectin-specific IgG level was found in ALA and intestinal amebiasis patients as compared with asymptomatic controls (61). In our study, we observed an increased frequency of new E. histolytica infections in children with serum IgG antibodies to the lectin (64). These findings suggested that systemic anti-lectin antibody response might not offer direct protection from amebiasis.…”

Section: Humoral Immune Response To E Histolyticacontrasting

confidence: 44%

Crosstalk at the initial encounter: interplay between host defense and ameba survival strategies

Guo

Houpt

Petri

2007

Current Opinion in Immunology

View full text Add to dashboard Cite

The host-parasite relationship is based on a series of interplays between host defense mechanisms and parasite survival strategies. Progress has been made in understanding the role of host immune response in amebiasis. While host cells elaborate diverse mechanisms for pathogen expulsion, amebae have also developed complex strategies to modulate host immune response and facilitate their own survival. This paper will give an overview of current research on the mutual interactions between host and Entamoeba histolytica in human and experimental amebiasis. Understanding this crosstalk is crucial for the effective design and implementation of new vaccines and drugs for this leading parasitic disease.

show abstract

Section: Humoral Immune Response To E Histolyticacontrasting

confidence: 44%

Crosstalk at the initial encounter: interplay between host defense and ameba survival strategies

Guo

Houpt

Petri

2007

Current Opinion in Immunology

View full text Add to dashboard Cite

show abstract

“…In addition to invasive disease, the parasite asymptomatically colonizes the intestine of up to 11% of endemic populations (2,3). The mechanisms of human resistance to colonization or invasive disease are poorly understood.…”

Section: Resistance Of C57bl/6 Mice To Amoebiasis Is Mediated By Nonhmentioning

confidence: 99%

“…The mechanisms of human resistance to colonization or invasive disease are poorly understood. One contributing factor is fecal IgA to the parasite, particularly to its galactose-inhibitable adherence lectin, which correlates with partial protection against infection in children and vaccinated mice (3,4). Additionally, a protective role for IFN-␥, TNF-␣, and NO on macrophages has been demonstrated in vitro (5).…”

Section: Resistance Of C57bl/6 Mice To Amoebiasis Is Mediated By Nonhmentioning

confidence: 99%

“…A majority of CBA or C3H (either TLR4 mutant or wild-type (WT)) 3 mice develop patent infections upon challenge. Early after infection, viable amoeba are seen predominantly at sites of epithelial breakdown and a robust inflammatory response ensues that is phenotypically protective, insofar as neutrophil-depleted or dexamethasone-treated C3H or CBA mice show increased infection rates and/or disease scores (9).…”

Section: Resistance Of C57bl/6 Mice To Amoebiasis Is Mediated By Nonhmentioning

confidence: 99%

See 1 more Smart Citation

Resistance of C57BL/6 Mice to Amoebiasis Is Mediated by Nonhemopoietic Cells but Requires Hemopoietic IL-10 Production

Hamano

Asgharpour

Stroup

et al. 2006

The Journal of Immunology

View full text Add to dashboard Cite

Resistance to intestinal amoebiasis is mouse strain dependent. C57BL/6 (B6) mice clear Entamoeba histolytica within hours of challenge, whereas C3H and CBA strains are susceptible to infection and disease. In this study, we show using bone marrow (BM) chimeric mice that mouse strain-dependent resistance is mediated by nonhemopoietic cells; specifically, B6 BM → CBA recipients remained susceptible as measured by amoeba score and culture, whereas CBA BM → B6 recipients remained resistant. Interestingly, hemopoietic IL-10 was required for maintaining the resistance of B6 mice, in that B6 IL-10-deficient mice and IL-10−/− BM → wild-type recipients, but not IL-10+/+ BM → IL-10−/− recipients, exhibited higher amoeba scores than their wild-type controls. Additionally, C57BL/10 IL-10−/−Rag2−/− mice exhibited diminished amoeba scores and culture rates vs IL-10−/− mice, indicating that lymphocytes potentiated the susceptibility of IL-10-deficient mice. We conclude that nonhemopoietic cells mediate the natural resistance to intestinal amoebiasis of B6 mice, yet this resistance depends on hemopoietic IL-10 activity.

show abstract

“…3 Various studies from rural areas of Central and South America, India, and the tropical areas of Asia and Africa have reported prevalence rate as high as 55%. 4,5 Pyogenic liver abscess has an estimated global incidence of 1.1-2.3 per 100,000 person-years and in United States, the incidence is approximately 3.6 per 100,000 and has been rising. 6 Broadly divided into amoebic liver abscess (ALA) and pyogenic liver abscess (PLA) with majority of amoebic etiology in developing countries and pyogenic in developed countries.…”

Section: Introductionmentioning

confidence: 99%

Clinical and biochemical profile of liver abscess patients

et al. 2017

View full text Add to dashboard Cite

Background: Liver comprises 48% of all the visceral abscesses. It is common in India with 2nd highest incidence due to poor sanitation, overcrowding and inadequate nutrition. Worldwide, approximately 40-50 million people are infected annually with amoebic abscesses. This study aims to observe the clinical and biochemical profile of liver abscess patients so that a prompt diagnosis can be made and early treatment can be given.Methods: The study was conducted over a period of 1 year on 50 patients of liver abscess. History and physical examination was done. All patients were subjected to complete hemogram, liver function test, coagulation profile (PT/INR) and USG abdomen. Serology for Entamoeba histolytica and HIV was done.Results: The mean age of the patients was 41.8 years with male preponderance. Amoebic liver abscess (86%) was predominant over pyogenic liver abscess (14%). Alcoholism (52%) and diabetes mellitus (20%) are main predisposing factors in case of liver abscess. Hepatomegaly was found in 80% cases. Elevated ALP, low albumin, increased PT INR points to the diagnosis of liver abscess. The abscesses were predominantly in right lobe (76%) and solitary (66%). Complications seen were ascites (12%) and pleural effusion (6%).Conclusions: Liver abscess should be suspected in patients presenting with prolonged fever and pain upper abdomen specially if patient is alcoholic or has diabetes mellitus. Ultrasonography is an easy and cost effective investigation to diagnose liver abscess. Early and aggressive treatment is the mainstay to prevent complications, morbidity and mortality.

show abstract

Innate and Acquired Resistance to Amebiasis in Bangladeshi Children

Cited by 144 publications

References 36 publications

Crosstalk at the initial encounter: interplay between host defense and ameba survival strategies

Crosstalk at the initial encounter: interplay between host defense and ameba survival strategies

Resistance of C57BL/6 Mice to Amoebiasis Is Mediated by Nonhemopoietic Cells but Requires Hemopoietic IL-10 Production

Clinical and biochemical profile of liver abscess patients

Contact Info

Product

Resources

About