Innate immune and growth promoting responses to caper ( Capparis spinosa ) extract in rainbow trout ( Oncorhynchus mykiss )

Bi̇len, Soner; Altunoğlu, Yasemin Çelik; Ulu, Ferhat; Biswas, Gouranga

doi:10.1016/j.fsi.2016.08.040

Cited by 56 publications

(31 citation statements)

References 55 publications

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“…Whether the stimulation was due to tetra remains unclear. Similar to our observation, MPO activity was improved in different fish species after administration of medicinal plants (Alexander, Kirubakaran, & Michael, ; Bilen, Altunoglu, et al, ; Bilen, Unal, et al, ; Kumar et al, ).…”

Section: Discussionsupporting

confidence: 89%

“…A dose-dependent elevated IL-1β gene expression was also observed in rainbow trout administered with capper (Bilen, Altunoglu, et al, 2016). Yuan et al (2008) also observed an increase in IL-1β gene expression in carp treated with Astragalus.…”

Section: Discussionmentioning

confidence: 71%

“…Similar results were observed in rainbow trout treated with U. barbata extract used as a remedy against L. garvieae infection. A dose‐dependent elevated IL‐1β gene expression was also observed in rainbow trout administered with capper (Bilen, Altunoglu, et al, ). Yuan et al () also observed an increase in IL‐1β gene expression in carp treated with Astragalus.…”

Section: Discussionmentioning

confidence: 83%

“…Dried plants were ground into powder. Aqueous methanolic extract of the pulverized plant was prepared according to the method described by Bilen, Altunoglu, Ulu, and Biswas (2016).…”

Section: Extract Preparationmentioning

confidence: 99%

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A new potential therapeutic remedy against Aeromonas hydrophila infection in rainbow trout (Oncorhynchus mykiss) using tetra, Cotinus coggygria

Bi̇len

Elbeshti

2019

Journal of Fish Diseases

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Different antibiotic‐based drugs are being used for the treatment of Aeromonas hydrophila infection in rainbow trout, and several studies emphasize the use of medicinal plants as immunostimulants for prophylactic measure against Aeromoniasis disease. However, therapeutic effects of aqueous methanolic extracts of tetra (Cotinus coggygria) against A. hydrophila in rainbow trout were not investigated. Four different concentrations of tetra extract (0 [control], 4, 8 and 12 mg/100 µl) and also two different positive control groups (florfenicol and doxycycline antibiotics) were administered orally using feeding needles to individual rainbow trout, Oncorhynchus mykiss of all experimental groups twice a day after intramuscular inoculation of A. hydrophila. The study period was for 10 days. On 0th, 3rd, 7th and 10th day, blood and tissues were collected from the fish and changes in humoral immune responses, haematology and immune‐related gene expressions were determined. In the study, superoxide radical production was decreased generally in all experimental groups except in 12 mg tetra and florfenicol treatments compared to control (p < .05). Lysozyme activity was generally decreased (p < .05), or no differences were observed in all experimental groups compared to the control. Myeloperoxidase activity was significantly increased in florfenicol‐treated fish group on 7th day (p < .05). Generally, myeloperoxidase activity showed an increase in almost all tetra‐treated groups. Haematological parameters increased but were not significantly high enough in treatments. Almost all immune‐related gene expressions were significantly enhanced on 3rd and 10th day of the study. Survival rate of 53.33% was found in control group. There were no significant differences in survival between control and 4 mg tetra‐treated group (p > .05). All the other groups' survival rate was significantly increased compared to control. The highest survival rate was found in florfenicol group (80%). In 12 mg tetra‐, doxycycline‐ and 8 mg tetra‐treated groups, survival rate was recorded as 74.44%, 70% and 70%, respectively. Our results suggest that tetra methanolic extract is an effective therapeutic remedy against A. hydrophila infection in rainbow trout at the dose of 24 mg/32.34 g body weight/day.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 71%

Section: Discussionmentioning

confidence: 83%

“…Dried plants were ground into powder. Aqueous methanolic extract of the pulverized plant was prepared according to the method described by Bilen, Altunoglu, Ulu, and Biswas (2016).…”

Section: Extract Preparationmentioning

confidence: 99%

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A new potential therapeutic remedy against Aeromonas hydrophila infection in rainbow trout (Oncorhynchus mykiss) using tetra, Cotinus coggygria

Bi̇len

Elbeshti

2019

Journal of Fish Diseases

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“…In China, C. spinosa (also named wild watermelon) mainly distributed in Xinjiang Uygur Autonomous Region, which is a kind of sand binding plant and its buds, leaves, roots, and fruits have been used in traditional Uighur Medicine to treat gout and rheumatoid arthritis for a long time [ 8 ]. Recently, many studies have been reported that C. spinosa contains a lot of biochemical compounds including flavonoids, alkaloids, polyphenols, saponins, terpenoids, lectin, essential oils, glycosinolate, and glycosides [ 6 , 9 , 10 , 11 , 12 ], which exhibited a broad range of activities such as anti-inflammatory [ 13 , 14 , 15 , 16 ], anti-viral [ 17 , 18 ], anti-allergeric [ 19 ], anti-arthritic [ 20 ], anti-tumor [ 9 , 17 , 21 ], anti-oxidant [ 22 , 23 , 24 , 25 , 26 ], anti-nociceptive [ 27 , 28 ], anti-diabetic [ 4 , 29 ], anti-hepatotoxic [ 30 ], anti-hyperglycemic [ 31 ], hypolipidemic [ 32 ], and immunomodulatory [ 18 , 33 ]. However, the effect of C. spinosa on the maturation and cytokine production of DCs is still elusive.…”

Section: Introductionmentioning

confidence: 99%

Capparis spinosa Fruit Ethanol Extracts Exert Different Effects on the Maturation of Dendritic Cells

Zhou

Aipire

et al. 2017

Molecules

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Capparis spinosa L. (C. spinosa) has been used as food and traditional medicine and shows anti-inflammatory and anti-oxidant activities. Here, we prepared the C. spinosa fruit ethanol extracts (CSEs) using different procedures and investigated the effects of CSE on the maturation of mouse bone marrow-derived dendritic cells (DCs) in the absence or presence of lipopolysaccharide (LPS). DC maturation and cytokine production were detected by flow cytometry and ELISA, respectively. We obtained three different CSEs and dissolved in water or DMSO, named CSE2W, CSEMW, CSE3W, CSE2D, CSEMD, and CSE3D, respectively. These CSEs showed different effects on DC maturation. CSEMW and CSEMD significantly increased the expressions of CD40, CD80, and CD86, in a dose-dependent manner. CSE2W and CSE2D also showed a modest effect on DC maturation, which enhanced the expression of CD40. CSE3W and CSE3D did not change DC maturation but suppressed LPS-induced DC maturation characterized by the decreased levels of CD40 and CD80. CSE3W and CSE3D also significantly inhibited the secretions of IL-12p40, IL-6, IL-1β, and TNF-α induced by LPS. CSE3W further increased the level of IL-10 induced by LPS. Moreover, CSE3D suppressed LPS-induced DC maturation in vivo, which decreased the expressions of CD40 and CD80. These results suggested that CSE3W and CSE3D might be used to treat inflammatory diseases.

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Biochemical, pharmacological, and toxicological attributes of caper (Capparis ovata) flowering buds and berries pickles

Ozgun‐Acar

Çelik-Turgut

Guner

et al. 2022

Food Science & Nutrition

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Innate immune and growth promoting responses to caper ( Capparis spinosa ) extract in rainbow trout ( Oncorhynchus mykiss )

Cited by 56 publications

References 55 publications

A new potential therapeutic remedy against Aeromonas hydrophila infection in rainbow trout (Oncorhynchus mykiss) using tetra, Cotinus coggygria

A new potential therapeutic remedy against Aeromonas hydrophila infection in rainbow trout (Oncorhynchus mykiss) using tetra, Cotinus coggygria

Capparis spinosa Fruit Ethanol Extracts Exert Different Effects on the Maturation of Dendritic Cells

Biochemical, pharmacological, and toxicological attributes of caper (Capparis ovata) flowering buds and berries pickles

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