Innate immune responses to Listeria in vivo

Maudet, Claire; Levallois, Sylvain; Disson, Olivier; Lecuit, Marc

doi:10.1016/j.mib.2020.11.006

Cited by 13 publications

(8 citation statements)

References 72 publications

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“…L. monocytogenes is an intracellular parasitic bacterium that can survive and proliferate within macrophages. Cell-mediated immunity by immune cells, such as activated macrophages and dendritic cells, plays an important role in the innate immune response against L. monocytogenes ( 5 ). CD38 is expressed in activated macrophages and is essential for their regulation.…”

Section: Discussionmentioning

confidence: 99%

<i>Listeria monocytogenes</i> Bacteremia During Isatuximab Therapy in a Patient with Multiple Myeloma

et al. 2021

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An elderly patient with multiple myeloma (MM) was being treated with several regimens and developed a severe drug eruption, necessitating the use of atovaquone instead of trimethoprim-sulfamethoxazole for pneumocystis pneumonia (PCP) prophylaxis. For progressive MM, treatment with isatuximab, an anti-CD38 monoclonal antibody, was started. During the treatment, he developed Listeria monocytogenes bacteremia and recovered quickly with ampicillin administration. CD38 is closely related to the innate immune response against L. monocytogenes, and isatuximab may increase the risk of infection. Therefore, trimethoprimsulfamethoxazole may be useful in the prevention of not only PCP but also L. monocytogenes infection.

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Section: Discussionmentioning

confidence: 99%

<i>Listeria monocytogenes</i> Bacteremia During Isatuximab Therapy in a Patient with Multiple Myeloma

et al. 2021

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“…Moreover, it remains unclear whether they are environmental reservoirs without the presence of shedding animals. 148,176,258 Fecal shedding from wild animals and bacterial persistence in invertebrates and protozoal carriers, as previously discussed, may promote bacterial introduction into the agricultural environment, 189,273,282,291 but a direct link between strains isolated from the pristine natural environment, farm environment, and ruminant host remains to be shown.…”

Section: Sources Of Farm Contaminationmentioning

confidence: 99%

Listeria monocytogenes at the interface between ruminants and humans: A comparative pathology and pathogenesis review

2021

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The bacterium Listeria monocytogenes ( Lm) is widely distributed in the environment as a saprophyte, but may turn into a lethal intracellular pathogen upon ingestion. Invasive infections occur in numerous species worldwide, but most commonly in humans and farmed ruminants, and manifest as distinct forms. Of those, neuroinfection is remarkably threatening due to its high mortality. Lm is widely studied not only as a pathogen but also as an essential model for intracellular infections and host-pathogen interactions. Many aspects of its ecology and pathogenesis, however, remain unclear and are rarely addressed in its natural hosts. This review highlights the heterogeneity and adaptability of Lm by summarizing its association with the environment, farm animals, and disease. It also provides current knowledge on key features of the pathology and (molecular) pathogenesis of various listeriosis forms in naturally susceptible species with a special focus on ruminants and on the neuroinvasive form of the disease. Moreover, knowledge gaps on pathomechanisms of listerial infections and relevant unexplored topics in Lm pathogenesis research are highlighted.

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“…The same changes of the abundance of the two genera occurred in the MA group compared to MO. Under normal condition, the treatment of astaxanthin decreased the abundance of Listeria , a kind of pathogen causing listeriosis, a severe disease with high hospitalization and case fatality rates ( Maudet et al, 2021 ). At the OTU level, the supplement of astaxanthin significantly affected the abundance of OTUs from the order Clostridiales—for example, OTU #780650, assigned to Clostridiaceae, which was significantly decreased in group A compared to group O, was also significantly decreased by astaxanthin under healthy and obese conditions, respectively.…”

Section: Discussionmentioning

confidence: 99%

Microbial Composition and Co-occurrence Patterns in the Gut Microbial Community of Normal and Obese Mice in Response to Astaxanthin

Gao

Liu

et al. 2021

Front. Microbiol.

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The changes and interaction of gut microbiota, which respond to dietary supplements, play critical roles on improving human health. The modulating effect of astaxanthin on gut microbiota has been reported. However, little is known about the co-occurrence patterns among microbial taxa in response to astaxanthin. In this study, the gut microbial composition, co-occurrence patterns, and microbial correlations with physiological parameters in astaxanthin-fed normal and obese mice were studied. Astaxanthin altered the microbial composition and co-occurrence patterns in normal and obese mice. Furthermore, astaxanthin gave more profound impacts on microbiota in obesity when compared with normal mice. In group A (normal or obese mice supplemented with astaxanthin), the abundance of Acinetobacter was decreased, and Alistipes was increased by astaxanthin, which also occurred in the MA group (obese mice supplemented with astaxanthin). An operational taxonomic unit (OTU) (GreenGeneID# 4029632) assigned to the genus Bacteroides acted as a connector in the global network of A and MA groups. It may play critical roles in bridging intimate interactions between the host and other bacteria intervened by astaxanthin. Several modules correlated with physiological parameters were detected. For example, modules A12 and MA10 were significantly and negatively correlated with lipopolysaccharide (LPS) and fasting blood glucose (FBG) levels, respectively. A positive correlation was found between the node connectivity of the OTUs belonging to Clostridiaceae with LPS in obese mice, which indicated the role of Clostridiales as a potential pathological marker. Our findings provided a new interpretation of the role of astaxanthin in health and may contribute to further research on microbial community engineering.

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Innate immune responses to Listeria in vivo

Cited by 13 publications

References 72 publications

<i>Listeria monocytogenes</i> Bacteremia During Isatuximab Therapy in a Patient with Multiple Myeloma

<i>Listeria monocytogenes</i> Bacteremia During Isatuximab Therapy in a Patient with Multiple Myeloma

Listeria monocytogenes at the interface between ruminants and humans: A comparative pathology and pathogenesis review

Microbial Composition and Co-occurrence Patterns in the Gut Microbial Community of Normal and Obese Mice in Response to Astaxanthin

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