Innate resistance of New Zealand paua to abalone viral ganglioneuritis

Corbeil, Serge; McColl, Kenneth A.; Williams, Lynette M.; Slater, Joanne; Crane, Mark St. J.

doi:10.1016/j.jip.2017.04.005

Cited by 13 publications

(8 citation statements)

References 15 publications

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“…In particular, HaHV-1 greatly challenged the abalone production in China as well as in other regions 4,12 . Similar to the bivalve OsHV-1 36,37 , HaHV-1 infects multiple hosts showing susceptibility to the virus 4,12,39 .…”

Section: Discussionmentioning

confidence: 99%

RNA-seq of HaHV-1-infected abalones reveals a common transcriptional signature of Malacoherpesviruses

Bai

Rosani

et al. 2019

Sci Rep

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Haliotid herpesvirus-1 (HaHV-1) is the viral agent causative of abalone viral ganglioneuritis, a disease that has severely affected gastropod aquaculture. Although limited, the sequence similarity between HaHV-1 and Ostreid herpesvirus-1 supported the assignment of both viruses to Malacoherpesviridae, a Herpesvirales family distantly related with other viruses. In this study, we reported the first transcriptional data of HaHV-1, obtained from an experimental infection of Haliotis diversicolor supertexta. We also sequenced the genome draft of the Chinese HaHV-1 variant isolated in 2003 (HaHV-1-CN2003) by PacBio technology. Analysis of 13 million reads obtained from 3 RNA samples at 60 hours post injection (hpi) allowed the prediction of 51 new ORFs for a total of 117 viral genes and the identification of 207 variations from the reference genome, consisting in 135 Single Nucleotide Polymorphisms (SNPs) and 72 Insertions or Deletions (InDels). The pairing of genomic and transcriptomic data supported the identification of 60 additional SNPs, representing viral transcriptional variability and preferentially grouped in hotspots. The expression analysis of HaHV-1 ORFs revealed one putative secreted protein, two putative capsid proteins and a possible viral capsid protease as the most expressed genes and demonstrated highly synchronized viral expression patterns of the 3 infected animals at 60 hpi. Quantitative reverse transcription data of 37 viral genes supported the burst of viral transcription at 30 and 60 hpi during the 72 hours of the infection experiment, and allowed the distinction between early and late viral genes.

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Section: Discussionmentioning

confidence: 99%

RNA-seq of HaHV-1-infected abalones reveals a common transcriptional signature of Malacoherpesviruses

Bai

Rosani

et al. 2019

Sci Rep

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“…Results showed that all HaHV-1 variants caused disease and mortality in all the abalone stocks tested (H. laevigata, H. rubra, and H. conicopora) [32], highlighting the vulnerability of the whole abalone fishery in Australia to future AVG outbreaks. Conversely, Corbeil et al [33] demonstrated that H. iris, the New Zealand päua, is highly resistant to disease and infection when challenged by immersion or injection with HaHV-1. This resistance contrasted with the disease susceptibility shown by most other Haliotis species tested to date [6,19,32].…”

Section: Virus-host Interactionmentioning

confidence: 99%

Abalone Viral Ganglioneuritis

Corbeil

2020

Pathogens

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Abalone viral ganglioneuritis (AVG), caused by Haliotid herpesvirus-1 (HaHV-1; previously called abalone herpesvirus), is a disease that has been responsible for extensive mortalities in wild and farmed abalone and has caused significant economic losses in Asia and Australia since outbreaks occurred in the early 2000s. Researchers from Taiwan, China, and Australia have conducted numerous studies encompassing HaHV-1 genome sequencing, development of molecular diagnostic tests, and evaluation of the susceptibility of various abalone species to AVG as well as studies of gene expression in abalone upon virus infection. This review presents a timeline of the most significant research findings on AVG and HaHV-1 as well as potential future research avenues to further understand this disease in order to develop better management strategies.

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“…As the nerve system is the primary target of the virus, the main clinical signs include poor pedal adhesion and swelling with prolapse of the mouth, which is not evident in a healthy animal [ 14 ]. These initial clinical signs eventually lead to the death of the animal in as short a period as 4–5 days following virus exposure [ 40 ].…”

Section: Herpesvirus Infection In Molluscsmentioning

confidence: 99%

Immune Control of Herpesvirus Infection in Molluscs

2020

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Molluscan herpesviruses that are capable of infecting economically important species of abalone and oysters have caused significant losses in production due to the high mortality rate of infected animals. Current methods in preventing and controlling herpesviruses in the aquacultural industry are based around biosecurity measures which are impractical and do not contain the virus as farms source their water from oceans. Due to the lack of an adaptive immune system in molluscs, vaccine related therapies are not a viable option; therefore, a novel preventative strategy known as immune priming was recently explored. Immune priming has been shown to provide direct protection in oysters from Ostreid herpesvirus-1, as well as to their progeny through trans-generational immune priming. The mechanisms of these processes are not completely understood, however advancements in the characterisation of the oyster immune response has assisted in formulating potential hypotheses. Limited literature has explored the immune response of abalone infected with Haliotid herpesvirus as well as the potential for immune priming in these species, therefore, more research is required in this area to determine whether this is a practical solution for control of molluscan herpesviruses in an aquaculture setting.

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Innate resistance of New Zealand paua to abalone viral ganglioneuritis

Cited by 13 publications

References 15 publications

RNA-seq of HaHV-1-infected abalones reveals a common transcriptional signature of Malacoherpesviruses

RNA-seq of HaHV-1-infected abalones reveals a common transcriptional signature of Malacoherpesviruses

Abalone Viral Ganglioneuritis

Immune Control of Herpesvirus Infection in Molluscs

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