Inner ear histopathology in “nervous Pointer dogs” with severe hearing loss

Coppens, Angélique; Gilbert-Gregory, Shana; Steinberg, Sheldon A.; Heizmann, Claus W.; Poncelet, Luc

doi:10.1016/j.heares.2004.08.019

Cited by 14 publications

(9 citation statements)

References 34 publications

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“…Congenital sensorineural deafness occurs in the dog, [40][41][42][43][44][45][46][47][48][49][50][51][52][53][54][55][56][57][58] cat, 59-65 llama, 66 alpaca, 66 and horse 67 (Table 9-1). Congenital sensorineural deafness typically is the result of a defect in the end organ (hair cells of the organ of Corti).…”

Section: Congenital Sensorineural Deafnessmentioning

confidence: 99%

Disorders of the Face, Tongue, Esophagus, Larynx, and Ear

Lorenz

2011

Handbook of Veterinary Neurology

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Section: Congenital Sensorineural Deafnessmentioning

confidence: 99%

Disorders of the Face, Tongue, Esophagus, Larynx, and Ear

Lorenz

2011

Handbook of Veterinary Neurology

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“…A late-onset inherited congenital sensorineural deafness is a form of congenital deafness which occurs later than in the above-mentioned breeds of dogs. It has been reported to occur at the age of 3 months in the Pointer, 5 years in the Border Collie, and from a few weeks old to 3 to 4 years of age in the Cavalier King Charles Spaniel (CKCS) (Podel, 1999;Coppens et al, 2005;DeLahunta et al, 2009;Schmutz, 2014). The probability of late-onset hearing loss was very low in our study since the median age of the studied dogs was 2.5 months.…”

Section: Discussionmentioning

confidence: 54%

Evaluation of the occurrence of canine congenital sensorineural deafness in puppies of predisposed dog breeds using the brainstem auditory evoked response

Płonek

Giza

Niedźwiedź

et al. 2016

Acta Veterinaria Hungarica

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Canine congenital sensorineural deafness (CCSD) affects predisposed breeds of dogs and is primarily caused by an atrophy of the stria vascularis of the organ of Corti. The analysis of the brainstem auditory evoked response (BAER) is a reliable method for the evaluation of hearing in animals as it allows an accurate detection of unilateral or bilateral deafness. The occurrence of unilateral and bilateral deafness using the BAER was determined in a representative group of dogs in Poland, including Bull Terriers (n = 117), Australian Cattle Dogs (n = 62), English Setters (n = 32) and the Dogo Argentino (n = 32). Overall deafness, deafness in each dog breed and an association between deafness and phenotype were studied. Among the 243 dogs tested, 156 (81%) had a normal BAER, 27 (11%) were unilaterally deaf, and 12 (5%) were bilaterally deaf. The amplitudes and latencies of waves I, II, III, V, the V/I wave amplitude ratio, and wave I-V, I-III and III-V inter-peak intervals were recorded for each dog. Unilaterally and bilaterally deaf dogs were present in all the dog breeds studied. There were 17 (14.5%) deaf Bull Terriers, three (4.8%) deaf Australian Cattle Dogs, seven (21.9%) deaf English Setters, and 12 (37.5%) deaf Dogos Argentinos. Preventive BAER screening should be routinely performed in these four breeds to prevent the spread of genes responsible for deafness.Key words: Canine congenital sensorineural deafness, dogs, brainstem auditory evoked response, predisposed breeds Analysis of the brainstem auditory evoked response (BAER) is the most reliable technique for the evaluation of hearing in animals (Wilson and Mills, 2005;Webb, 2009;Wacławska-Matyjasik, 2010). It is carried out by recording the activity of the vestibulocochlear nerve and the auditory part of the brainstem.

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“…; Coppens et al . ). In the Doberman, the inheritance appears to be simple autosomal recessive (Strain ) and the condition may also be associated with vestibular signs (Wilkes & Palmer ).…”

Section: Introductionmentioning

confidence: 97%

Consequences of a screening programme on the prevalence of congenital hereditary sensorineural deafness in the Australian Cattle Dog

et al. 2014

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SummaryGenetic disease testing programmes are used in domestic animal breeds to guide selective breeding with the aim of reducing disease prevalence. We assessed the change in the prevalence of canine congenital hereditary sensorineural deafness (CHSD) in litters of Australian Cattle Dogs following the introduction of a brainstem auditory evoked response (BAER) testing programme. We studied 608 pups from 122 litters from 10 breeding kennels. Despite 10 years of testing (1998)(1999)(2000)(2001)(2002)(2003)(2004)(2005)(2006)(2007)(2008), no substantial reduction in prevalence of CHSD was evident in these 10 breeding kennels. Even for the subset of litters in which both parents were BAER tested as normal hearing (305 pups from 58 litters), there was no evidence of substantial reduction in prevalence. Odds ratios for CHSD in pups for each extra year since testing in the kennel commenced were 1.01 (95% CI, 0.88-1.17) and 1.03 (95% CI, 0.82-1.30) respectively for these populations. Amongst 284 dogs from 54 litters with extended pedigrees and both parents BAER-tested normal hearing, observed prevalences of CHSD were highest in pups with no BAER-tested normal grandparents (17% or 5/29) and lowest in pups with all four grandparents tested normal (0% or 0/9). In pups for which one, two and three grandparents tested negative, prevalences of CHSD were 12% (9/74), 9% (9/ 101) and 8% (6/71) respectively. Hence, testing programmes based on phenotypic screening may not lead to a substantial reduction in recessive genetic disease prevalence over the medium term, even when only tested normal parents are used. Exclusive breeding of litters in which both parents and all four grandparents are BAER-tested normal is expected to reduce CHSD prevalence in pups to the greatest extent over the long term.

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Inner ear histopathology in “nervous Pointer dogs” with severe hearing loss

Cited by 14 publications

References 34 publications

Disorders of the Face, Tongue, Esophagus, Larynx, and Ear

Disorders of the Face, Tongue, Esophagus, Larynx, and Ear

Evaluation of the occurrence of canine congenital sensorineural deafness in puppies of predisposed dog breeds using the brainstem auditory evoked response

Consequences of a screening programme on the prevalence of congenital hereditary sensorineural deafness in the Australian Cattle Dog

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