Innervation of synovial membrane and meniscus

Grönblad, Mats; Korkala, O; Liesi, Päivi; Karaharju, Erkki

doi:10.3109/17453678508993040

Cited by 72 publications

(25 citation statements)

References 10 publications

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“…[36][37][38][39] Occasionally, ENK immunoreactivity was also found in nerve fibres, consistent with previous studies on animals and humans. [40][41][42][43] Both END-and ENK-IR cells were significantly more abundant in patients with RA than in those with JT and OA, in parallel with the highest degree of inflammatory parameters in patients with RA. These findings suggest that increases of opioid peptide-containing cells are correlated with the inflammatory activity in the joint.…”

Section: Discussionmentioning

confidence: 94%

-Endorphin, Met-enkephalin and corresponding opioid receptors within synovium of patients with joint trauma, osteoarthritis and rheumatoid arthritis

Mousa

Straub

Schäfer

et al. 2007

Annals of the Rheumatic Diseases

108

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Objective: Intra-articularly applied opioid agonists or antagonists modulate pain after knee surgery and in chronic arthritis. Therefore, the expression of b-endorphin (END), Met-enkephalin (ENK), and m and d opioid receptors (ORs) within synovium of patients with joint trauma (JT), osteoarthritis (OA) and rheumatoid arthritis (RA) were examined. Methods: Synovial samples were subjected to double immunohistochemical analysis of opioid peptides with immune cell markers, and of ORs with the neuronal markers calcitonin gene-related peptide (CGRP) and tyrosine hydroxylase (TH). Results: END and ENK were expressed by macrophage-like (CD68 + ) and fibroblast-like (CD68 2 ) cells within synovial lining layers of all disorders. In the sublining layers, END and ENK were mostly expressed by granulocytes in patients with JT, and by macrophages/monocytes, lymphocytes and plasma cells in those with OA and RA. Overall, END-and ENK-immunoreactive (IR) cells were more abundant in patients with RA than in those with OA and JT. ORs were found on nerve fibres and immune cells in all patients. OR-IR nerve fibres were significantly more abundant in patients with RA than in those with OA and JT. mORs and dORs were coexpressed with CGRP but not with TH. Conclusions: Parallel to the severity of inflammation, END and ENK in immune cells and their receptors on sensory nerve terminals are more abundant in patients with RA than in those with JT and OA. These findings are consistent with the notion that, with prolonged and enhanced inflammation, the immune and peripheral nervous systems upregulate sensory nerves expressing ORs and their ligands to counterbalance pain and inflammation.

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Section: Discussionmentioning

confidence: 94%

-Endorphin, Met-enkephalin and corresponding opioid receptors within synovium of patients with joint trauma, osteoarthritis and rheumatoid arthritis

Mousa

Straub

Schäfer

et al. 2007

Annals of the Rheumatic Diseases

108

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“…On the contrary, fibrous capsule, ligaments and periosteum are richly innervated structures, displaying both somatic and sympathetic innervation [11,12]. The demonstration of nerve fibres immunoreactive to substance P in the synovium, but not in the perisynovial structures [13], raises the possibility of different mechanisms to elicit pain threshold in articular structures.…”

Section: Discussionmentioning

confidence: 99%

Periarthritis promotes gait disturbance in zymosan-induced arthritis in rats

et al. 1999

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“…ATP is converted to adenosine in the extracellular space by the ecto-5′-nucleotidase, which is located at the surface of macrophages and other cells (CD73) in the vicinity of the nerve terminal 45. Secondly, the primary sensory afferent nerve fibres with the two neurotransmitters, substance P and calcitonin gene-related peptide, also innervate the synovial tissue 46. Thirdly, vasoactive intestinal peptide belongs to the non-adrenergic non-cholinergic type of peripheral nerve fibres which are also present in this tissue 47.…”

Section: Neurotransmitter Interactions With Immune Cellsmentioning

confidence: 99%