Innervation of the Lumbar Intervertebral Disc by Nerve Growth Factor-Dependent Neurons Related to Inflammatory Pain

Aoki, Yasuchika; Ohtori, Seiji; Takahashi, Kazuhisa; Ino, Hiromitsu; Takahashi, Yoshi; Chiba, Tetsuhiro; Moriya, Hideshige

doi:10.1097/00007632-200405150-00005

Cited by 103 publications

(80 citation statements)

References 22 publications

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“…However, the ratios of IB4-binding and P2X 3 receptor-IR neurons to FG-labeled neurons in L1 and L2 DRGs were higher than those in L3, L4 and L5 DRGs (P<0.01) GDNF receptor [6,26]. Aoki et al [3] have reported that rat intervertebral discs are innervated mostly by CGRP-IR NGF-dependent small neurons, and that disc inflammation caused an increase in CGRP-IR neurons, but not IB4-binding neurons, suggesting that CGRP-IR NGF-dependent neurons have an overriding responsibility for discogenic pain. Furthermore, it has also been reported that NGF and trkA-expressing nerve fibers are present in painful lumbar discs in humans [14].…”

Section: Characteristics Of Sensory Drg Neurons Innervating the Facetmentioning

confidence: 96%

“…We used four markers: (1) calcitonin gene-related peptide (CGRP) as a marker of small peptide containing neurons, (2) the glycoprotein binding the isolectin from Griffonia simplicifolia (IB4) or (3 the purinergic P2X 3 receptor for small, non-peptide containing neurons, and (4) neurofilament 200 (NF200) for small and large myelinated fibers. IB4-binding and CGRP and P2X 3 receptor containing neurons are typically involved in pain sensation, whereas NF200 is associated with pain and proprioception. Neurons innervating the L5/6 facet joints, retrogradely-labeled with fluorogold (FG), were distributed throughout DRGs from L1 to L5.…”

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Characteristics of sensory DRG neurons innervating the lumbar facet joints in rats

et al. 2005

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Section: Characteristics Of Sensory Drg Neurons Innervating the Facetmentioning

confidence: 96%

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confidence: 99%

Characteristics of sensory DRG neurons innervating the lumbar facet joints in rats

et al. 2005

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“…(6,70,71) The most significant biochemical change to occur in DD is loss of proteoglycan. (72) The aggrecan molecules become degraded, with smaller fragments being able to leach from the tissue more readily than larger portions.…”

Section: Molecular Mechanisms Of Iddmentioning

confidence: 99%

Intervertebral Disc Degeneration and Low Back Pain: Molecular Mechanisms and Stem Cell Therapy

2018

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BACKGROUND: Low back pain (LBP) mostly caused by disc degeneration, reflects to a tremendous of health care system and economy. More knowledge about these underlying pathologies will improve the opportunities that may represent critical therapeutic targets.CONTeNT: Basic research is advancing the understanding of the pathogenesis and management of LBP at the molecular and genetic levels. Cytokines such as matrix metalloproteinases, phospholipase A2, nitric oxide, and tumor necrosis factor-α are thought to contribute to the development of LBP. Mesenchymal stem cells (MSCs) transplant to cartilage-like cells and secrete extracellular matrix and encourage nucleus pulposus (NP) cell activity Abstract R E V I E W A R T I C L Einhibiting NP cell apoptosis, together with some chemical mediators such as cytokines and growth factors become a safe and effective new strategy for intervertebral disc degeneration (IDD) treatment and regeneration.SUMMARy: IDD occurs where there is a loss of homeostatic balance with a predominantly catabolic metabolic profile. A basic understanding of the molecular changes occurring in the degenerating disc is important for practicing clinicians to help them to inform patients to alter lifestyle choices, identify beneficial or harmful supplements, or offer new biologic, genetic, or stem cell therapies.

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“…In addition it is an invasive procedure and it implies the injection of an adjacent normal disc to confirm a positive response. Therefore this diagnostic modality should be reserved for patients with presumed discogenic LBP who may be candidates for surgical treatment [57] due to its invasive nature and poor evidence for its sensitivity, specificity, and predictive value.…”

Section: Imaging the Intervertebral Discmentioning

confidence: 99%

Discogenic pain: Who cares?

Lavrador¹,

Simas²,

Oliveira³

et al. 2013

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Chronic low back pain has a huge impact on daily living and a negative economic and professional effect. It is a matter of debate and concern for all health professionals involved, particularly spine surgeons. Recent discoveries on the innervation and biochemical properties of the intervertebral disc clarify the role of this structure as a possible cause of chronic low back pain. However, multiple causes may be present in the same patient making the diagnosis a challenging process. Discogenic pain is defined as a chronic low back pain induced by a degenerative disc disease. There are no specific characteristics of discogenic pain, although it has a higher incidence in younger age, it is usually localized medially in the back, worsens with axial loading and improves with recumbence. In the last decades we have assisted the emergence of multiple treatment techniques. However, neither the conservative treatment nor the interventional management has strong evidence in treating discogenic pain. Randomized control clinical trials are sought to improve patient outcome. Meanwhile, we believe each patient should be approached on an individual base. Discogenic pain: we care.

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Innervation of the Lumbar Intervertebral Disc by Nerve Growth Factor-Dependent Neurons Related to Inflammatory Pain

Abstract: We found that most small neurons innervating the disc were CGRP-ir. Furthermore, disc inflammation caused an increase in CGRP-ir neurons but not IB4-binding neurons, suggesting that CGRP-ir, nerve growth factor-dependent neurons are more responsible for discogenic pain.

Cited by 103 publications

References 22 publications

Characteristics of sensory DRG neurons innervating the lumbar facet joints in rats

Characteristics of sensory DRG neurons innervating the lumbar facet joints in rats

Intervertebral Disc Degeneration and Low Back Pain: Molecular Mechanisms and Stem Cell Therapy

Discogenic pain: Who cares?

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