Intervertebral Disc Degeneration and Low Back Pain: Molecular Mechanisms and Stem Cell Therapy

Meiliana, Anna; Dewi, Nurrani Mustika; Wijaya, Andi

doi:10.18585/inabj.v10i1.426

Cited by 3 publications

(2 citation statements)

References 207 publications

(178 reference statements)

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“…Bertambahnya beban pada IVD akan menimbulkan kompresi yang dapat mengubah struktur anatomi IVD, seperti kerusakan Endplate dan berkurangnya ketinggian AF. 22 Apabila kompresi terjadi secara berulang dan terjadi dalam jangka waktu yang lama dapat memberikan dampak penggunaan berlebihan kepada IVD yang akan mencetuskan NPB atau bahkan menyebabkan degenerasi. 17 Hal ini sesuai dengan hasil penelitian yang dilakukan Raya et al (2019) yang menyatakan bawah peningkatan beban IVD dalam jangka waktu yang lama dapat meningkatkan resiko terjadinya NPB, sehingga seseorang dengan masa kerja yang lebih lama beresiko lebih besar mengalami keluhan NPB daripada seseorang yang memiliki masa kerja baru.…”

Section: Tabel 1 Hasil Pencarian Artikel Penelitianunclassified

Sikap Berdiri Lama Dalam Menimbulkan Nyeri Punggung Bawah

2022

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Sikap seseorang dilingkungan kerja, seperti duduk, jongkok, dan berdiri, sering dikaitan dengan kemunculan keluhan nyeri punggung bawah (NPB), namun sikap berdiri lama belum banyak ditemukan pembahasannya dalam media jurnal Indonesia. Studi literatur ini menggunakan metode pencarian artikel penelitian dalam database jurnal PubMed dan Google Scholar. Ada 6 jurnal yang menyatakan sikap berdiri lama berhubungan signifikan dengan NPB, namun 2 jurnal lainnya menyatakan sebaliknya. Sikap berdiri lama yang melebihi 20 menit dapat memberikan stress pada otot posterior tubuh dan persendian columna vertebralis, terutama di regio lumbal yang dapat menimbulkan keluhan NPB dengan tingkat dan kualitas nyeri yang bervariasi. Adanya faktor pekerjaan seperti beban kerja, lama kerja, sikap kerja, bantuan alat, dan banyaknya jam istirahat, serta faktor personal, seperti usia, merokok, jenis kelamin dan IMT, dapat ikut mempengaruhi kemunculan NPB pada seseorang, sehingga seseorang yang memiliki masa kerja yang lebih lama beresiko lebih besar mengalami keluhan NPB daripada seseorang yang memiliki masa kerja baru. Faktor-faktor ini dapat berpotensi memberikan bias pada hasil penelitian apabila tidak dipersiapkan dengan cermat.

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Section: Tabel 1 Hasil Pencarian Artikel Penelitianunclassified

Sikap Berdiri Lama Dalam Menimbulkan Nyeri Punggung Bawah

2022

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“…Degenerative disc disease (DDD) progresses with age and involves metabolic disorders and recovery of degenerative altered MHD tissue. The degenerative and inflammatory processes that occur during disc degeneration contribute to the growth of nerve fibers and blood vessels in the disc, which potentially explains the development of pain in such patients [9,10].…”

Section: Introductionmentioning

confidence: 99%

Ultrasonography in the diagnosis of lumbar disc herniation in young adult

Abdullaeiv

Mamedov²

2022

SR:MS

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The aim: to assess the value of ultrasonography in the diagnosis of a lumbar herniation disc in young adults. Material and methods: 27 patients aged 17-21 years (8 girls, 19 boys) were included in our study. During the examination by a neurologist, all patients reported pain in the lower back. The results of the ultrasound investigation were compared with MRI. Ultrasonography (USG) was conducted on a Philips HD 11XE device using a convection transducer in the frequency range 2-5 MHz; MRI - General Electric, Signa HDI, 1.5T. Results: at the L3-L4 segment, hernia was diagnosed in 2 (7.4±5.0 %) cases, at the L4-L5 segment - in 14 (51.9±9.6 %) cases, and at the L5-S1 segment - in 11 (40.7±9.5 %) cases, respectively. The hernia at the segments of L5-S1 and L4-L5 was diagnosed significantly (P<0.001) more often than at the segment of L3-L4. Median hernia was diagnosed in 12 (44.4±9.6 %) cases, paramedian - in 11 (40.7±9.5 %) cases and posterolateral - in 4 ( 14.8±6.8 %) cases, respectively. The median and paramedian hernia was diagnosed significantly (P<0.05) more than the posterolateral. In ultrasound, only in one case, a posterolateral hernia was interpreted as paramedian Conclusions: 1) The lumbar hernia are localized at the segments of L5-S1 and L4-L5 significantly (P<0.001) more often than at the other segments; 2) Sciatica is significantly more common in posterolateral localization of lumbar disc herniation; 3) The ultrasonography couldbe used to find out the causes of back pain in young adult

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Diagnostic Radiology Methods of Degenerative Changes in Lumbar Intervertebral Discs in Young People

Mammadov

2020

IMJ

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In recent years, the number of scientific studies investigating the prevalence of low back pain among schoolchildren has been significantly increased. Degenerative disease of the discs is often accompanied by a low back pain with irradiation into the legs in representatives of different age groups, in particular, in older children. The main factors of its development are genetic predisposition, trauma, obesity, lack of exercise. Most of the components of the vertebral motor segment have the nerve endings and reflex influences, accompanied by inflammation, microcirculatory disorders, and their combination contributes to an appearance of back pain. Diagnosis of degenerative disc disease includes the study of the patient's medical history, analysis of clinical symptoms, use of functional tests and various types of imaging to clarify the degree of macrostructural changes in disks, among which the main place is taken by the magnetic resonance imaging. The development of degenerative changes in intervertebral discs as early as childhood, which requires a further study using non−invasive, accessible and informative methods, especially ultrasound ones. The results of ultrasonography of lumbar intervertebral discs were analyzed in 36 adolescents aged 16−18 years, diagnosed for the protrusion when the MRI was applied. Paramedian protrusion was found to be significantly more frequent than posterolateral, median, and circular ones. Due to its non−invasiveness, low price and information value, the ultrasound can be the most popular method not only as a screening one but also for the expert evaluation of lumbar intervertebral disc protrusion in schoolchildren. Key words: diagnostic radiology, lumbar intervertebral discs, adolescents.

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Intervertebral Disc Degeneration and Low Back Pain: Molecular Mechanisms and Stem Cell Therapy

Cited by 3 publications

References 207 publications

Sikap Berdiri Lama Dalam Menimbulkan Nyeri Punggung Bawah

Sikap Berdiri Lama Dalam Menimbulkan Nyeri Punggung Bawah

Ultrasonography in the diagnosis of lumbar disc herniation in young adult

Diagnostic Radiology Methods of Degenerative Changes in Lumbar Intervertebral Discs in Young People

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