Since 2020, social movements, organizations, and nation-states in Latin America have taken concrete actions in response to the COVID-19 crisis. Although contingency policies were promoted, it did not take long for inequities to become visible. The paid domestic work sector, historically feminized, was strongly affected by the COVID-19 crisis. While Latin American governments launched various assistance policies for the domestic work sector, a contemporary regional initiative of Latin American women, CONLACTRAHO, was also working with its members to help them retain their jobs while risking contracting the disease. Here, we will explore the initiatives developed by some Latin American governments and strategies from CONLACTRAHO in the context of the care crisis and the COVID-19 crisis. These examples will allow us to reflect, from a qualitative, intersectional, and decolonial approach, on commonalities and differences between the civil society agenda and the gender agenda of nation-states in the region. We understand that the unequal labor conditions of domestic workers are strongly related to the societal gender regime that historically distributes roles, opportunities, and resources among gender categories. This work is part of a broader reflection regarding the process of Latin American regional construction and its interrelation with contemporary ideas of nation.