Introduction/objective: Manufacturing industries are a key pillar for Mexico, regarded as a strategic sector that promotes economic balance and advanced technological use. This study aims to analyze how organizational innovation influences the adaptability of manufacturing companies in Cajeme, with a focus on innovation in management, commerce, products, and services. Methodology: A quantitative-correlational methodology was adopted, utilizing structural equation modeling. Six manufacturing companies from the automotive, aerospace, pharmaceutical, industrial, electronic, and chemical sectors were analyzed. Results: The findings indicate that manufacturing companies exhibit a positive influence of innovation on adaptability. These companies tend to prioritize process innovation over product innovation. Conclusions: Process innovation has a more significant impact on manufacturing companies, resulting in enhanced adaptability. Future research should focus on product and commercial innovation, as these areas demonstrated lower levels of influence and adaptability in this study.