Innovation in rigid bronchoscopy—past, present, and future

Aravena, Carlos; Mehta, Atul C.; Almeida, F. A. C.; Lamb, Carla; Maldonado, Fabien; Gildea, Thomas R.

doi:10.21037/jtd-22-779

Cited by 5 publications

(2 citation statements)

References 114 publications

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“…First introduced in the 1960s by Japanese thoracic surgeon Shigeto Ikeda, flexible bronchial fibroscopy, or bronchoscopy [38,39], is the indispensable procedure applied by respiratory physicians to investigate the throat and airway or respiratory tract. Bronchoscopies can also be used to aspirate mucus, mucus plugs, and/or to perform bronchoalveolar lavage; however, the invasive nature of fibroscopy is still a primary limitation of the exam in gravely ill patients [33,39]. Today, sputum specimens are collected by one of the two non-invasive methods-either the expectorated or the induced procedure.…”

Section: Methods and Systems Utilized To Study Sputum Proteomicsmentioning

confidence: 99%

Human Sputum Proteomics: Advancing Non-Invasive Diagnosis of Respiratory Diseases with Enhanced Biomarker Analysis Methods

Guzman,

Guzman

2024

IJTM

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Many ailments can be diagnosed while they are asymptomatic, meaning that the patient has no signs or symptoms of a progressing disease. If caught in their initial stage of formation, these disorders can be effectively treated, leading to successful outcomes; curative therapies can halt illnesses from advancing, thus improving the quality of life and long-term survival of the patient. Still, cutting-edge upgrades in precision technologies are necessary for early, reliable, affordable, and rapid disease detection, but also vital for the well-being of people and the future of global public health. The emerging role and utility of non-invasive and repeatable diagnostic test approaches for the detection of health conditions have been exemplified by liquid biopsies based on genomic biomarkers. As such, biological fluids permit any measurable molecular indicator or signature (e.g., proteins) to provide valuable information on an individual’s wellness and/or disease. Among the bodily secretions used for non-invasive diagnostics is sputum, a complex viscous gel-like biopolymeric network that has gained growing recognition as a rich source of biomarkers of airway infections and pulmonary diseases, and serves as a determinant to reveal other illnesses. As per the World Health Organization, the burden of respiratory conditions is exacerbated by factors ranging from considerable subjection to air pollution and occupational contaminants to tobacco smoking and second-hand smoke, in addition to poor socio-economic status. Due to the likely increase in these determinants, respiratory tract ailments are on the rise, affecting the health of many individuals, in addition to putting stress on healthcare facilities and services worldwide. The aim of this study was to perform a narrative review of sputum constituents with an emphasis on proteins and glycoproteins assessed as possible biomarkers of lung and other organ diseases. A search was conducted using mucus, sputum proteomics, sputum biomarkers, and point-of-care testing as keywords employing Google, PubMed (MEDLINE), and Web of Science, selecting the most referenced and related papers of the last decade. We, therefore, highlight the need to use expectorated or induced sputum specimens as a routine sample source for testing valuable protein biomarkers to diagnose these chronic disorders, predict inflammation and disease progression, as well as monitor the effectiveness of treatments. Further, we discuss the urgent need for fast and reliable point-of-care methods to detect and quantify crucial protein biomarkers in sputum specimens, and the limitations faced when dealing with their complex matrices.

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Section: Methods and Systems Utilized To Study Sputum Proteomicsmentioning

confidence: 99%

Human Sputum Proteomics: Advancing Non-Invasive Diagnosis of Respiratory Diseases with Enhanced Biomarker Analysis Methods

Guzman,

Guzman

2024

IJTM

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“…Despite being well‐tolerated in most cases, long‐term follow‐ups have revealed significant drawbacks, including granulation tissue obstruction, stent migration, excessive immune response, infections, mucus retention, and lumen collapse, as documented in researche with extended follow‐up periods. 136 , 137 …”

Section: Advancements In Clinical Translationmentioning

confidence: 99%

Tissue‐engineered tracheal implants: Advancements, challenges, and clinical considerations

Wei,

Zhang,

Luo

et al. 2024

Bioengineering & Transla Med

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Restoration of extensive tracheal damage remains a significant challenge in respiratory medicine, particularly in instances stemming from conditions like infection, congenital anomalies, or stenosis. The trachea, an essential element of the lower respiratory tract, constitutes a fibrocartilaginous tube spanning approximately 10–12 cm in length. It is characterized by 18 ± 2 tracheal cartilages distributed anterolaterally with the dynamic trachealis muscle located posteriorly. While tracheotomy is a common approach for patients with short‐length defects, situations requiring replacement arise when the extent of lesion exceeds 1/2 of the length in adults (or 1/3 in children). Tissue engineering (TE) holds promise in developing biocompatible airway grafts for addressing challenges in tracheal regeneration. Despite the potential, the extensive clinical application of tissue‐engineered tracheal substitutes encounters obstacles, including insufficient revascularization, inadequate re‐epithelialization, suboptimal mechanical properties, and insufficient durability. These limitations have led to limited success in implementing tissue‐engineered tracheal implants in clinical settings. This review provides a comprehensive exploration of historical attempts and lessons learned in the field of tracheal TE, contextualizing the clinical prerequisites and vital criteria for effective tracheal grafts. The manufacturing approaches employed in TE, along with the clinical application of both tissue‐engineered and non‐tissue‐engineered approaches for tracheal reconstruction, are discussed in detail. By offering a holistic view on TE substitutes and their implications for the clinical management of long‐segment tracheal lesions, this review aims to contribute to the understanding and advancement of strategies in this critical area of respiratory medicine.

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Place de l’endoscopie dans la gestion des nodules pulmonaires périphériques, partie 2 : traitement

Lachkar,

Guisier,

Dantoing

et al. 2024

Revue des Maladies Respiratoires

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Innovation in rigid bronchoscopy—past, present, and future

Cited by 5 publications

References 114 publications

Human Sputum Proteomics: Advancing Non-Invasive Diagnosis of Respiratory Diseases with Enhanced Biomarker Analysis Methods

Human Sputum Proteomics: Advancing Non-Invasive Diagnosis of Respiratory Diseases with Enhanced Biomarker Analysis Methods

Tissue‐engineered tracheal implants: Advancements, challenges, and clinical considerations

Place de l’endoscopie dans la gestion des nodules pulmonaires périphériques, partie 2 : traitement

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