<p>Multi-Core Supertall Buildings is connected by coupling trusses, whose main structural feature is significantly different from traditional core-tube structures. The strength of the connection between the coupling trusses and the main structure is the main influence factor of the structure index and the bearing capacity of the main components. Therefor sensitivity analysis should be conducted on the impact of the coupling trusses and adjustments should be taken to control the structure index. The paper takes a multi-core supertall as an engineering case to explore the impact of the coupling trusses under earthquake stiffness constraints on the structural performance. The case showes that sensitivity analysis can comprehensively test the impact of coupling trusses on multi-core supertall buildings and the key parts that need to be strengthened, which improved the performance of the structure, promoted the rationality and economy of engineering design.</p>