Innovative Drug Delivery Systems for Infectious Diseases of the Skin

Esentürk-Güzel, İmren; Kara, Bilge Ahsen

doi:10.22270/ujpr.v7i4.815

Cited by 3 publications

(2 citation statements)

References 43 publications

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“…Refractive indices of the prepared micro emulsions were determined at 25°C by Abbe's refractometer by placing one drop of micro emulsion on the slide 20 .…”

Section: Refractive Indexmentioning

confidence: 99%

Development and Evaluation of Microemulsion Formulations of Lornoxicam

Islam

Uddin²

2023

Univ J Pharm Res

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Background and aims: Microemulsions (ME) basically are the mixture of oil, surfactant (SA) and water, with a co surfactant (Co-SA) in different ratio. This mixture is clear and stable. The final prepared fluid possesses low viscosity. ME are isotropic, stable transparent systems of with a droplets diameter>500 nm. Due to small droplets size, they may serve an excellent carrier for drugs having poor water solubility. Lornoxicam is derivative of allylamine, and is used orally in the treatment of hepatic failure, neutropenia. Methods: In the present study an attempt was made to increase solubility of Lornoxicam by the means of ME formulations. Oil, surfactant and co-surfactant were selected based on their solubility criteria. Total 5 formulations were developed using water titration method. Prepared formulations were evaluated on different parameters. Results: The percent transmission was found to be in the range of 98.48±0.15to 99.42±0.04. Refractive index for the micro emulsion formulations was found to be in the range of 1.3218±0.009 to 1.3720±0.021. Percent drug content was found to be in the range of 98.47±0.08 to 99.75±0.21. ME5 has shown faster drug release 91.2±0.06% in an in-vitro study of 4 hrs. Conclusion: Study concluded that the means of microemulsions formulations solubility of Lornoxicam can be enhanced. Peer Review History: Received: 15 November 2022; Revised: 8 December; Accepted: 9 January 2023, Available online: 15 January 2023 Academic Editor: Dr. Sally A. El-Zahaby, Pharos University in Alexandria, Egypt, sally.elzahaby@yahoo.com Received file: Reviewer's Comments: Average Peer review marks at initial stage: 6.0/10 Average Peer review marks at publication stage: 7.5/10 Reviewers: Dr. Bilge Ahsen KARA, Ankara Gazi Mustafa Kemal Hospital, Turkey, ahsndkyc@gmail.com Dr. George Zhu, Tehran University of Medical Sciences, Tehran, Iran, sansan4240732@163.com Similar Articles: FORMULATION AND CHARACTERIZATION OF TOPICAL NANO EMULGEL OF TERBINAFINE

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“…Refractive indices of the prepared micro emulsions were determined at 25°C by Abbe's refractometer by placing one drop of micro emulsion on the slide 20 .…”

Section: Refractive Indexmentioning

confidence: 99%

Development and Evaluation of Microemulsion Formulations of Lornoxicam

Islam

Uddin²

2023

Univ J Pharm Res

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“…These agents form the oily phase if the emulsion. For externally applied emulsions, mineral oils, or combined with soft or hard paraffin's are widely used both as the vehicle for the drug and for their occlusive and sensory characteristics [17].…”

Section: Oilsmentioning

confidence: 99%

Emulgel as a Novel Drug Delivery System: A Comprehensive Review

Joshi

Kumar

Khairya

et al. 2020

Int J Indig Herb Drug

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Nowadays emulgel systems are currently of attention to the pharmaceutical scientists because of their substantial potential to act as drug delivery vehicle by incorporating a broad range of drug molecules. Emulgel is one of the recent technology in NDDS used topically having characteristics of dual control release i.e. emulsion as well as gel. Emulgels have emerged as one of the most interesting topical delivery systems as it has dual release control system i.e. gel and emulsion. When gel and emulsion are used in combined form, the dosage form are referred as emulgel. In current review article, various aspects of the emulgel are discussed.

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Formulation and evaluation of ivermectin emulgel formulations

Joshi,

Kumar,

Negi

et al. 2023

World Journal of Current Med and Pharm Research

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Ivermectin, a broad-spectrum antiparasitic agent, has demonstrated significant therapeutic efficacy against various skin conditions. However, it's poor skin permeability and limited stability often hinder its clinical application. Emulgel, a hybrid dosage form combining the advantages of both emulsions and gels, has emerged as a promising topical delivery system to enhance the skin permeation and stability of poorly permeable drugs. In this study, we aimed to formulate and characterize an Ivermectin emulgel to address the challenges associated with its topical delivery. The emulgel was prepared using a two-step method, involving the preparation of an oil-in-water (o/w) emulsion, which was then gelled with suitable gelling agents. Different concentrations of Ivermectin, oil phase, surfactants, and gelling agents were screened to optimize the formulation for maximum drug loading and stability. The optimized Ivermectin emulgel was characterized for its physicochemical properties, including pH, viscosity, spreadability, drug content, and rheological behavior. The study's findings support the potential application of the emulgel in treating various skin conditions caused by parasites and infectious agents. Further, in vivo studies and clinical trials are required to validate its safety and effectiveness in a clinical setting.

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Innovative Drug Delivery Systems for Infectious Diseases of the Skin

Cited by 3 publications

References 43 publications

Development and Evaluation of Microemulsion Formulations of Lornoxicam

Development and Evaluation of Microemulsion Formulations of Lornoxicam

Emulgel as a Novel Drug Delivery System: A Comprehensive Review

Formulation and evaluation of ivermectin emulgel formulations

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