Innovative magnetic tri-layered nanocomposites based on polyxanthone triazole, polypyrrole and iron oxide: synthesis, characterization and investigation of the biological activities

Abstract

A magnetic multi-functional composite with a tri-layer core-shell-shell construction was successfully prepared by a combination process involving click reactions and emulsion polymerization. Firstly, magnetic polyxanthone triazole (PXT) was synthesized via the click reaction of bisethynyl and 2,7-(N-2chloroacetamide) xanthone (NClX) in the presence of Fe 3 O 4 nanoparticles. Then, a polypyrrole@polyxanthone triazole@Fe 3 O 4 (PPy@PXT@Fe 3 O 4 ) tri-layered nanocomposite was prepared via emulsion polymerization of pyrrole in the presence of magnetic PXT using sodium dodecyl sulfate (SDS) as an emulsifier and ammonium persulfate (APS) as an oxidant. Characterization of the synthesized polymer and nanocomposite was carried out by nuclear magnetic resonance (NMR), Fourier transform infrared (FT-IR), X-ray diffraction (XRD), scanning electron microscopy (SEM), thermal gravimetric analysis (TGA), Brunauer-Emmett-Teller (BET) survey, transmission electron microscopy (TEM) and vibrating sample magnetometer (VSM) studies. Also, the antioxidant activity of the nanocomposites was examinedand compared with the bare polymer using a 2,2-diphenyl-1-picryl-hydrazyl free radical (DPPHc) assay.In addition, the in vitro antibacterial activities of the di-layered and tri-layered nanocomposites were studied by inhibition zone methods. The results showed a greater synergic effect in the thermal stability, antioxidant and antibacterial activities of the tri-layered nanocomposite than of the di-layered nanocomposite. Thus, the developed PPy@PXT@Fe 3 O 4 tri-layered nanocomposite could be used effectively for biomedical applications and would be a good sorbent candidate for the microbial treatment of wastewater.

Novel anticancer and antibacterial organometallic polymer based on ferrocene as a building block and xanthone bioactive scaffolds: Synthesis, characterization, and biological study

“…According to our previous works in the synthesis and investigation of the bioactive polymers that were containing the 1,2,3‐triazole rings and xanthone moiety, and by reviewing the other projects that determined the antibacterial activity of the ferrocene and azine base material, it was decided to investigate the antibacterial activity of the synthesized polymer that have several active sites for bacteria denaturation. Hence, the in vitro antibacterial activity of the synthesized polymer containing 1,2,3‐triazole, ferrocene, xanthone, and azine units against clinical isolates of Gram‐positive and Gram‐negative pathogens such as E coli (ATCC 25922), S aureus (ATCC 25923), K pneumoniae (NCTC 5056), P aeruginosa (1561), and B subtilis 1715 (PY79) bacterial strains was tested and compared with penicillin, ciprofloxacin, and gentamicin as reference antibacterials.…”

“…In continuation of our previous works on the synthesis of functional polymers and their nanocomposites with biological properties and capability in removal of cationic water pollutants, [53][54][55][56]…”

“…According to our previous works in the synthesis and investigation of the bioactive polymers that were containing the 1,2,3-triazole rings and xanthone moiety, 53,54 and by reviewing the other projects that Three antibiotics were selected for their antibacterial activity through standard bacteria strains according to However, B subtilis and S aureus were sensitive toward gentamicin and penicillin antibiotics according to antimicrobial measurements data given in Table 2. Comparison of the synthesized polymer with the known commercial antibiotics is not logical.…”

“…In continuation of our previous works on the synthesis of functional polymers and their nanocomposites with biological properties and capability in removal of cationic water pollutants, herein, the synthesis, characterization, and some biological aspect of poly(azine ferrocene‐triazole‐xanthone amide) (PAFTXA) with reliable bioapplications were discussed in details. The purposes of the current study were design, preparation, characterization, and investigation of biological properties of novel‐clicked polymer‐bearing biologically valuable moieties of ferrocene, xanthone, triazole ring, and azine bond in the main chain.…”

Synthesis, characterization and antibacterial evaluation of nanofibrillated cellulose grafted by a novel quinolinium silane salt

“…2 In this context, a wide range of antimicrobial materials including polymers and biopolymers, molecular compounds, and nanoparticles have been developed for many applications in the elds ranging from engineering to medicine. [3][4][5][6] In recent years, an ever increasing interest has been focused on the use of green and eco-friendly bio-based materials, especially polysaccharides, because of their inherent renewable character, intrinsic biocompatibility, biodegradability, and nontoxicity towards living organisms. 7 Among the available natural polysaccharides, cellulose, as one of the most abundant biopolymers, is an excellent candidate for a wide range of applications in various elds including textiles, food packaging, pharmaceuticals, biomedical, and other health-related applications.…”