Innovative nanotools for vascular drug delivery: the atherosclerosis case study

Atanasio, Giulia De Negri; Ferrari, Pier Francesco; Campardelli, Roberta; Perego, Patrizia; Palombo, Domenico

doi:10.1039/d1tb01071a

Cited by 5 publications

(4 citation statements)

References 78 publications

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“…Because current non-specific therapies possess drawbacks, including limited distribution in the body, rapid elimination, and unwanted side effects, new strategies are required to enhance the treatment of this disease entity. There has been recent interest in the use of nanotechnology to help address some of these limitations [ 81 ].…”

Section: Electrospinning In Cardiac Tissue Engineeringmentioning

confidence: 99%

Exploring Electrospun Scaffold Innovations in Cardiovascular Therapy: A Review of Electrospinning in Cardiovascular Disease

Broadwin,

Imarhia,

et al. 2024

Bioengineering

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Cardiovascular disease (CVD) remains the leading cause of mortality worldwide. In particular, patients who suffer from ischemic heart disease (IHD) that is not amenable to surgical or percutaneous revascularization techniques have limited treatment options. Furthermore, after revascularization is successfully implemented, there are a number of pathophysiological changes to the myocardium, including but not limited to ischemia-reperfusion injury, necrosis, altered inflammation, tissue remodeling, and dyskinetic wall motion. Electrospinning, a nanofiber scaffold fabrication technique, has recently emerged as an attractive option as a potential therapeutic platform for the treatment of cardiovascular disease. Electrospun scaffolds made of biocompatible materials have the ability to mimic the native extracellular matrix and are compatible with drug delivery. These inherent properties, combined with ease of customization and a low cost of production, have made electrospun scaffolds an active area of research for the treatment of cardiovascular disease. In this review, we aim to discuss the current state of electrospinning from the fundamentals of scaffold creation to the current role of electrospun materials as both bioengineered extracellular matrices and drug delivery vehicles in the treatment of CVD, with a special emphasis on the potential clinical applications in myocardial ischemia.

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Section: Electrospinning In Cardiac Tissue Engineeringmentioning

confidence: 99%

Exploring Electrospun Scaffold Innovations in Cardiovascular Therapy: A Review of Electrospinning in Cardiovascular Disease

Broadwin,

Imarhia,

et al. 2024

Bioengineering

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“…Another emerging technology is represented by phytosomes, patented by the Italian company Indena S.p.A. (De Negri Atanasio et al, 2021), which are vesicles of phospholipids and phytoconstituents that exert their activities as a consequence of their size, their membrane permeability, and their entrapment efficiency (Tripathy et al, 2013).…”

Section: Bioengineered-based Strategies For Polyphenol Encapsulationmentioning

confidence: 99%

An extensive review on phenolic compounds and their potential estrogenic properties on skin physiology

Rispo,

De Negri Atanasio,

Demori

et al. 2024

Front. Cell Dev. Biol.

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Polyphenolic compounds constitute a diverse group of natural components commonly occurring in various plant species, known for their potential to exert both beneficial and detrimental effects. Additionally, these polyphenols have also been implicated as endocrine-disrupting (ED) chemicals, raising concerns about their widespread use in the cosmetics industry. In this comprehensive review, we focus on the body of literature pertaining to the estrogenic properties of ED chemicals, with a particular emphasis on the interaction of isoflavones with estrogen receptors. Within this review, we aim to elucidate the multifaceted roles and effects of polyphenols on the skin, exploring their potential benefits as well as their capacity to act as ED agents. By delving into this intricate subject matter, we intend to provoke thoughtful consideration, effectively opening a Pandora’s box of questions for the reader to ponder. Ultimately, we invite the reader to contemplate whether polyphenols should be regarded as friends or foes in the realm of skincare and endocrine disruption.

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“…As a result, Ab-engineered liposomes could be prepared by Ab physical adsorption, covalent attachment, and via adaptor biomolecules [19]. During the last decades, different drug delivery systems have been described, i.e., lipid-based nanosystems [20], polymeric nanoparticles [21], nanotubes [22], nanodiamonds [23], and nanofibers [24]. Among them, liposomes are vesicles made of lipids, such as phosphatidylcholine (PC), that could be produced by different techniques, i.e., the Bangham method, detergent depletion method, ethanol/ether injection method, reverse phase evaporation method, emulsion-based method, freeze-drying of monophase solutions, microfluidic channel method, sonication, and supercritical fluid-assisted technologies [25,26].…”

Section: Introductionmentioning

confidence: 99%

Operating Parameters Optimization for the Production of Liposomes Loaded with Antibodies Using a Supercritical Fluid-Assisted Process

et al. 2023

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Encapsulation of antibodies represents a significant advance to protect and deliver these therapeutics in a controlled manner, increasing the stability requested to cover the temporal gap between particle production and their administration. Furthermore, using encapsulation, extracellular, cell surface, and intracellular targets can be reached. This work examines the feasibility of encapsulating mouse IgG isotype control antibodies within phosphatidylcholine-based liposomes using a supercritical fluid-based process called SuperLip (Supercritical-assisted Liposome formation). This process allows a continuous production of both nano- and micrometric liposomes with high encapsulation efficiency working under mild operative conditions. The effect of some operative parameters has been studied on liposome mean diameter, particle size distribution, and antibody entrapment efficiency, comparing these data with those collected working with liposomes obtained by the thin-layer hydration technique. In particular, the effect of water flow rate and of the antibody loading were studied. Antibody-loaded liposomes with mean diameters in the range between 205 and 501 nm have been obtained by using a supercritical fluid-assisted process. High entrapment efficiencies up to 94% have been calculated.

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Innovative nanotools for vascular drug delivery: the atherosclerosis case study

Abstract: Cardiovascular diseases are the leading cause of mortality in the Western world. Among them, atherosclerosis (ATH) represents one the most common diseases in the modern world due to the common...

Cited by 5 publications

References 78 publications

Exploring Electrospun Scaffold Innovations in Cardiovascular Therapy: A Review of Electrospinning in Cardiovascular Disease

Exploring Electrospun Scaffold Innovations in Cardiovascular Therapy: A Review of Electrospinning in Cardiovascular Disease

An extensive review on phenolic compounds and their potential estrogenic properties on skin physiology

Operating Parameters Optimization for the Production of Liposomes Loaded with Antibodies Using a Supercritical Fluid-Assisted Process

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