Innovative Plasma Generation in Flexible Biopsy Channels for Inner‐Tube Decontamination and Medical Applications

Polák, Martin; Winter, J.; Schnabel, Uta; Ehlbeck, Jörg; Weltmann, Klaus‐Dieter

doi:10.1002/ppap.201000163

Cited by 54 publications

(44 citation statements)

References 20 publications

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“…It exhibits temperatures below thermal cell damage and has a unique composition of exited atoms, ions, electrons, neutral molecules, free radicals, electric fields, ultraviolet (UV), thermal and infrared radiation [1,2]. Its antibacterial effects are well documented [3,4] and there have been various medical applications such as decontamination of heat sensitive endoscopes and ablation of dental biofilms [5,6]. Preliminary trials showed that plasma application significantly reduced the bacterial load in chronic wounds [7] and potentially stimulated epithelial cells [8,9].…”

Section: Introductionmentioning

confidence: 99%

Non-thermal plasma treatment induces MAPK signaling in human monocytes

et al. 2014

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Abstract:The application of non-thermal atmospheric pressure plasma raises a hope for the new wound healing strategies. Next to its antibacterial effect it is known to stimulate skin cells. However, monocytes are also needed for the complex process of a wound healing. This study investigates the impact of plasma on the intracellular signaling events in the primary human monocytes. The proliferative MEK-ERK (MAPK/ERK kinase-extracellular signal-regulated kinase) pathway was activated by short plasma treatment times. In contrast, an induction of the apoptotic JNK (c-Jun N-terminal kinase) cascade as well as activation of caspase 3 were observed after long plasma exposure. These findings indicate that monocytes can be differentially stimulated by plasma treatment and may contribute to the proper wound recovery.

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Section: Introductionmentioning

confidence: 99%

Non-thermal plasma treatment induces MAPK signaling in human monocytes

et al. 2014

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“…The development of different plasma sources and devices led to an explosion of research in plasma medicine. First, main focus of plasma application was the improvement of chronic infected wounds [1–3] and disinfection of surgical instruments or catheters [4] since plasma is effective in the inactivation of different microorganisms [5–10] and removal of biofilms [11–13]. Meanwhile, nonthermal plasma was also investigated for application in several other fields, for example, in dental applications, in changing surfaces of medical implants, in treating cancer or dermatological diseases, and in plastic surgery [14–16].…”

Section: Introductionmentioning

confidence: 99%

Differential Influence of Components Resulting from Atmospheric-Pressure Plasma on Integrin Expression of Human HaCaT Keratinocytes

Haertel

Straßenburg²,

Oehmigen³

et al. 2013

BioMed Research International

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Adequate chronic wound healing is a major problem in medicine. A new solution might be non-thermal atmospheric-pressure plasma effectively inactivating microorganisms and influencing cells in wound healing. Plasma components as, for example, radicals can affect cells differently. HaCaT keratinocytes were treated with Dielectric Barrier Discharge plasma (DBD/air, DBD/argon), ozone or hydrogen peroxide to find the components responsible for changes in integrin expression, intracellular ROS formation or apoptosis induction. Dependent on plasma treatment time reduction of recovered cells was observed with no increase of apoptotic cells, but breakdown of mitochondrial membrane potential. DBD/air plasma increased integrins and intracellular ROS. DBD/argon caused minor changes. About 100 ppm ozone did not influence integrins. Hydrogen peroxide caused similar effects compared to DBD/air plasma. In conclusion, effects depended on working gas and exposure time to plasma. Short treatment cycles did neither change integrins nor induce apoptosis or ROS. Longer treatments changed integrins as important for influencing wound healing. Plasma effects on integrins are rather attributed to induction of other ROS than to generation of ozone. Changes of integrins by plasma may provide new solutions of improving wound healing, however, conditions are needed which allow initiating the relevant influence on integrins without being cytotoxic to cells.

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“…The most interesting property of strong localization of atmospheric pressure discharges is the possibility of using the plasma reactivity to treat a welldefined target area. This characteristic can be exploited to access hard-to-reach regions such as the interior of organs through endoscopes (Polak et al 2012) or catheters (Sato et al 2008). Here, we will emphasize two innovative plasma devices used in medical applications.…”

Section: Plasmas In Medicine and Pharmacymentioning

confidence: 98%

“…Due to a jet-like plasma expanding outside the end of the tube it can be used as an endoscope for cancer treatment. In harder-toreach regions inside the body such as lungs, pancreas and duodenum, a 15 m sized microplasma jet based on a hollow-core optical fiber was proposed (Polak et al 2012). With this very localized plasma a single-cellular level treatment might be possible.…”

Section: Plasmas In Medicine and Pharmacymentioning

confidence: 99%

Applications of Low-Temperature Plasmas

Loureiro

Amorim

2016

Graduate Texts in Physics

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Low-temperature plasmas are present in a broad field of technological applications and experimented an enormous growth after the end of the twentieth century. The most important examples of applications are lamps, pretreatment of polymer materials, packaging materials, treatment of surfaces, waste, air pollution mitigation, microelectronics, and flat panels display. Recently new applications in medicine, pharmacy, foods, biology, biomass and biofuel processing, attracted the interest of the industry and the scientific community.The purpose of this chapter is not to be exhaustive but illustrates some important industrial and technological applications. The fields where low-temperature plasmas are being employed today is vast, rapidly growing, and cannot be described in a single book chapter, so clearly well beyond this textbook. Of course, much will be left out, however a special emphasize will be stressed here in these new breakthrough applications of plasmas in health science, production of biofuels and agriculture. Plasmas for Materials ProcessingPlasma technologies are being used in industry due to their ability to offer a wide spectrum of possible treatments of materials. These plasmas are in fact source of heat and reactive species that have unique physical and chemical properties induced by charged particles. The main applications of these discharges are (Bonizzoni and Vassallo 2002): destruction of toxic/harmful materials, superficial modification of materials and creation of new materials.In industry basically two kind of plasmas are employed; the plasma torches which are thermal plasmas produced at high pressure by direct current, alternating electric fields like RF or microwaves. These plasmas have electron temperatures around

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Innovative Plasma Generation in Flexible Biopsy Channels for Inner‐Tube Decontamination and Medical Applications

Cited by 54 publications

References 20 publications

Non-thermal plasma treatment induces MAPK signaling in human monocytes

Non-thermal plasma treatment induces MAPK signaling in human monocytes

Differential Influence of Components Resulting from Atmospheric-Pressure Plasma on Integrin Expression of Human HaCaT Keratinocytes

Applications of Low-Temperature Plasmas

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