Innovative Research Exploring the Effects of Physical Activity and Genetics on Cognitive Performance in Community-Based Older Adults

Etnier, Jennifer L.; Labban, Jeffrey D.; Karper, William B.; Wideman, Laurie; Piepmeier, Aaron; Shih, Chia Hao; Castellano, Michael A.; Williams, Lauren; Park, Se Yun; Henrich, Vincent C.; Dudley, William N.; Rulison, Kelli L.

doi:10.1123/japa.2014-0221

Cited by 11 publications

(9 citation statements)

References 74 publications

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“…Full details regarding the parent study design have been published previously (Etnier et al, 2015). A brief overview of the parent study is described herein with additional details provided as relevant to this study.…”

Section: Methodsmentioning

confidence: 99%

Motivating Mature Adults to be Physically Active

Etnier¹,

Karper²,

Park³

et al. 2017

Journal of Aging and Physical Activity

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As a population, middle-aged and older adults are not meeting national guidelines for exercise. The purpose of this study was to describe factors associated with exercise adherence in an 8-month program offered as part of a research study testing the effects of exercise on cognitive performance for persons with a family history of Alzheimer’s disease (AD). After completion of the program, participants provided open-ended responses indicating their reasons for adhering to the exercise program, and they completed the Motives for Physical Activities Measure-Revised. Results indicated that adherence was tied to an interest in contributing to our understanding of AD, the opportunity to join an exercise program, perceived exercise benefits, and social support. Additionally, participants reported high levels of extrinsic (fitness-related) and intrinsic (interest/enjoyment) motivation. Other possible motivating factors which emerged from day-to-day observations in the program were identified. Findings suggest directions for exercise professionals with respect to exercise adherence.

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Section: Methodsmentioning

confidence: 99%

Motivating Mature Adults to be Physically Active

Etnier¹,

Karper²,

Park³

et al. 2017

Journal of Aging and Physical Activity

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“…Detailed methods and a consort flow diagram for the Physical Activity and Alzheimer’s Disease (PAAD) study have been previously published (33). Hence, the study methods are briefly described herein.…”

Section: Methodsmentioning

confidence: 99%

The Physical Activity and Alzheimer’s Disease (PAAD) Study: Cognitive outcomes

Etnier

Karper

Labban

et al. 2018

Annals of Behavioral Medicine

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“…Individuals who only reported family members with diagnosed forms of dementia other than AD, such as vascular dementia or dementia with Lewy bodies, are not included. Although APOE4+ make up approximately 24% of the general U.S. population < 65 years of age [107], based upon previous research [37,108], recruiting adults with a FH+ increases the percent of APOE4+ tõ 35%. Thus, by recruiting 240 people with a FH+, we anticipate successfully enrolling approximately 80 APOE4+ participants.…”

Section: Eligibility Criteriamentioning

confidence: 99%

“…Validity checks will be performed as recommended [157]. Standard Operating Procedures (SOPs) for cognitive testing, the PAC intervention, submaximal exercise testing, and blood draws are in place from our Phase I clinical trial (PAAD) [108]. Modifications to the SOP to reflect the addition of cognitive measures and updates to procedures were made prior to participant recruitment.…”

Section: Data Managementmentioning

confidence: 99%

The effect of physical activity on cognition relative to APOE genotype (PAAD-2): study protocol for a phase II randomized control trial

et al. 2020

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Background By 2050, the prevalence of Alzheimer’s disease (AD) in the United States is predicted to reach 13.8 million. Despite worldwide research efforts, a cure for AD has not been identified. Thus, it is critical to identify preventive strategies that can reduce the risk of or delay the onset of AD. Physical activity (PA) has potential in this regard. This randomized clinical trial aims to (a) test the causal relationship between PA and AD-associated cognitive function for persons with a family history of AD (FH+), (b) determine the moderating role of apolipoprotein epsilon 4 (APOE4) carrier status on cognition, and (c) assess cerebral structure, cerebral function, and putative biomarkers as mediators of the effects of PA on cognition. Methods We are recruiting cognitively normal, middle aged (40–65 years) sedentary adults with FH+. Participants are randomly assigned to a 12-month PA intervention for 3 days/week or to a control group maintaining their normal lifestyle. Saliva samples are taken at pre-test to determine APOE genotype. At pre-, mid-, and post-tests, participants complete a series of cognitive tests to assess information-processing speed, verbal and visual episodic memory, constructional praxis, mnemonic discrimination, and higher-order executive functions. At pre- and post-tests, brain imaging and blood biomarkers are assessed. Discussion We hypothesize that 1) the PA group will demonstrate improved cognition compared with controls; 2) PA-derived cognitive changes will be moderated by APOE4 status; and 3) PA-induced changes in neural and blood biomarkers will contribute to cognitive changes and differ as a function of APOE4 status. Our results may provide important insights into the potential of PA to preserve neurocognitive function in people with a heightened risk of AD due to FH+ and as moderated by APOE4 status. By using sophisticated analytic techniques to assess APOE as a moderator and neurobiological mechanisms as mediators across trajectories of cognitive change in response to PA, we will advance our understanding of the potential of PA in protecting against AD. Trial registration ClinicalTrials.gov NCT03876314. Registered March 15, 2019.

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Innovative Research Exploring the Effects of Physical Activity and Genetics on Cognitive Performance in Community-Based Older Adults

Cited by 11 publications

References 74 publications

Motivating Mature Adults to be Physically Active

Motivating Mature Adults to be Physically Active

The Physical Activity and Alzheimer’s Disease (PAAD) Study: Cognitive outcomes

The effect of physical activity on cognition relative to APOE genotype (PAAD-2): study protocol for a phase II randomized control trial

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