Innovative spectrofluorimetric determination of vildagliptin based on a “switch off/on” NS-doped carbon dot nanosensor

Elshenawy, Eman A.; El‐Malla, Samah F.; Hammad, Sherin F.; Mansour, Fotouh R.

doi:10.1039/d2ra04991k

Cited by 15 publications

(1 citation statement)

References 38 publications

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“…These hormones are vital for maintaining normal blood glucose levels by increasing glucagon and insulin release in the pancreas. Several analytical techniques have been reported in the literature for the determination of vildagliptin, such as spectrophotometry [23][24][25][26][27], spectrofluorime-try [28], chromatography [29][30][31][32][33][34], capillary electrophoresis [35], and voltammetry [36]. Two potentiometric methods have been reported for the determination of vildagliptin.…”

Section: Introductionmentioning

confidence: 99%

Utilization of a TiO2–CuO Bimetallic/Polyaniline Nanocomposite as a Transducer in a Solid Contact Potentiometric Sensor for the Determination of Vildagliptin

Abdallah,

Ahmed,

Almaghrabi

et al. 2023

Polymers

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Current fundamental electrochemical research shows the potential of utilizing polymeric nanostructured materials as ion-to-electron transducers. In this paper, aniline was polymerized in the presence of TiO2 and CuO nanoparticles to yield a bimetallic/PANI nanocomposite. It was applied as a transducer in a carbon paste electrode for the potentiometric determination of vildagliptin in the presence of 18-crown-6-ether as a recognition element. The electrode’s potentiometric performance was studied according to the IUPAC guidelines. It exhibited a wide linearity range of 1 × 10−2 M to 1 × 10−8 M, remarkable sensitivity (LOD of 4.5 × 10−9 M), and a fast response time of 10 s ± 1.3. The sensor did not show any potential drift due to the absence of the water layer between the carbon paste and the metallic conductor. This endowed the sensor with high stability and a long lifetime, as 137 days passed without the need to change the carbon paste surface. The electrode was utilized for the determination of the concentration of vildagliptin in bulk, pharmaceutical tablets, and human plasma, with average recovery ranging from 97.65% to 100.03%.

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Section: Introductionmentioning

confidence: 99%

Utilization of a TiO2–CuO Bimetallic/Polyaniline Nanocomposite as a Transducer in a Solid Contact Potentiometric Sensor for the Determination of Vildagliptin

Abdallah,

Ahmed,

Almaghrabi

et al. 2023

Polymers

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Nitrogen and Sulfur Co‐Doped Carbon Quantum Dots as Fluorescent Nanosensors for Determination of Two Tetracycline Antibiotics in Dosage Forms and Human Plasma: Compliance With Greenness Metrics

El‐libeshy,

Abdel‐Megied,

Rashed

et al. 2024

Luminescence

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In this study, a novel, sensitive, and cost‐effective spectrofluorimetric approach was established for the estimation of two important tetracycline antibiotics, tetracycline and doxycycline, without any pre‐treatment procedures or harsh reaction conditions, for the first time. The proposed methodology is based on the quantitative quenching effect of each tetracycline and doxycycline on the native fluorescence of nitrogen and sulfur co‐doped carbon quantum dots (NS‐CQDs). A simple and ultrafast approach was applied to synthesize NS‐CQDs using thiosemicarbazide and citric acid as starting materials after incubation in a microwave for only 1 min. Utilizing an excitation wavelength of 360 nm, NS‐CQDs showed maximum emission peak at 430 nm. Calibration curves revealed excellent linearity within the ranges of 1.0–10.0 and 0.8–12.0 μg/mL with detection limits of 0.20 and 0.09 μg/mL for tetracycline and doxycycline, respectively. Due to the method's high sensitivity and selectivity, the proposed approach was applied for the determination of the studied drugs in their capsules and human plasma samples with high %recoveries. The developed approach was validated according to ICHQ2(R2) guidelines. GAPI and AGREE metric tools were used to verify the method's greenness and eco‐friendliness, suggesting its use as a green substitute for the analysis of the studied drugs.

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New emerging materials with potential antibacterial activities

Bedair,

Hamed,

Mansour

2024

Appl Microbiol Biotechnol

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The increasing prevalence of multidrug-resistant pathogens is a critical public health issue, necessitating the development of alternative antibacterial agents. Examples of these pathogens are methicillin-resistant Staphylococcus aureus (MRSA) and the emergence of “pan-resistant” Gram-negative strains, such as Pseudomonas aeruginosa and Acinetobacter baumannii, which occurred more recently. This review examines various emerging materials with significant antibacterial activities. Among these are nanomaterials such as quantum dots, carbon quantum dots, metal–organic frameworks (MOFs), covalent organic frameworks (COFs), and layered double hydroxides, all of which demonstrate excellent antibacterial properties. Interestingly, including antibacterial agents within the structure of these materials can help avoid bacterial resistance and improve the long-term efficacy of the materials. Additionally, the antibacterial potential of liquid solvents, including ionic liquids and both deep eutectic solvents and natural deep eutectic solvents, is explored. The review discusses the synthesis methods, advantages, and antibacterial efficacy of these new materials. By providing a comprehensive overview of these innovative materials, this review aims to contribute to the ongoing search for effective solutions to combat antibiotic resistance. Key studies demonstrating antibacterial effects against pathogens like Escherichia coli, Staphylococcus aureus, and multidrug-resistant strains are summarized. MOFs have exhibited antibacterial properties through controlled ion release and surface interactions. COFs have enhanced the efficacy of encapsulated antibiotics and displayed intrinsic antibacterial activity. Other nanomaterials, such as quantum dots, have generated reactive oxygen species, leading to microbial inactivation. This review aims to provide insights into these new classes of antibacterial materials and highlight them for addressing the global crisis of antibiotic resistance. Key points • Nanomaterials show strong antibacterial effects against drug-resistant bacteria • Emerging solvents like ionic liquids offer novel solutions for bacterial resistance • MOFs and COFs enhance antibiotic efficacy, showing promise in combating resistance

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Innovative spectrofluorimetric determination of vildagliptin based on a “switch off/on” NS-doped carbon dot nanosensor

Abstract: Microwave synthesis of a switchable sensor as a label-free recognition system for VLD determination. The sensor was applied for VLD determination in dosage form and human urine.

Cited by 15 publications

References 38 publications

Utilization of a TiO2–CuO Bimetallic/Polyaniline Nanocomposite as a Transducer in a Solid Contact Potentiometric Sensor for the Determination of Vildagliptin

Utilization of a TiO2–CuO Bimetallic/Polyaniline Nanocomposite as a Transducer in a Solid Contact Potentiometric Sensor for the Determination of Vildagliptin

Nitrogen and Sulfur Co‐Doped Carbon Quantum Dots as Fluorescent Nanosensors for Determination of Two Tetracycline Antibiotics in Dosage Forms and Human Plasma: Compliance With Greenness Metrics

New emerging materials with potential antibacterial activities

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