Innovative Topical Formulations for Treatment of Dermatitis

Şenyiğit, Taner; Özcan, İpek; Özer, Özgen

doi:10.2174/187221312802652785

Cited by 6 publications

(4 citation statements)

References 109 publications

(140 reference statements)

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“…Samples were withdrawn at scheduled time points (10,30,60, and 90 days) and analyzed in terms of all characterization properties.…”

Section: Stability Of Formulationsmentioning

confidence: 99%

“…These formulations have been proposed to increase percutaneous absorption of therapeutic agents as well as reducing the damage to the skin barrier function. [8][9][10][11] A desired formulation for this purpose should ideally be able to pass through the stratum corneum (SC) and be able to maintain therapeutically relevant concentrations in the epidermis/dermis, without high serum levels and systemic exposure.…”

Section: Introductionmentioning

confidence: 99%

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Enhanced dermal delivery of diflucortolone valerate using lecithin/chitosan nanoparticles: in-vitro and in-vivo evaluations

Özcan¹,

Azizoğlu²,

Şenyiğit³

et al. 2013

IJN

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Abstract:The objective of this study was to prepare a suitable formulation for dermal delivery of diflucortolone valerate (DFV) that would maintain the localization in skin layers without any penetration and to optimize efficiency of DFV. Drug-loaded lecithin/chitosan nanoparticles with high entrapment efficiency (86.8%), were successfully prepared by ionic interaction technique. Sustained release of DFV was achieved without any initial burst release. Nanoparticles were also incorporated into chitosan gel at different ratios for preparing a more suitable formulation for topical drug delivery with adequate viscosity. In ex-vivo permeation studies, nanoparticles increased the accumulation of DFV especially in the stratum corneum + epidermis of rat skin without any significant permeation. Retention of DFV from nanoparticle in chitosan gel formulation (0.01%) was twofold higher than commercial cream, although it contained ten times less DFV. Nanoparticles in gel formulations produced significantly higher edema inhibition in rats compared with commercial cream in in-vivo studies. Skin blanching assay using a chromameter showed vasoconstriction similar to that of the commercial product. There were no barrier function changes upon application of nanoparticles. In-vitro and in-vivo results demonstrated that lecithin/chitosan nanoparticles in chitosan gel may be a promising carrier for dermal delivery of DFV in various skin disorders.

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“…Samples were withdrawn at scheduled time points (10,30,60, and 90 days) and analyzed in terms of all characterization properties.…”

Section: Stability Of Formulationsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Enhanced dermal delivery of diflucortolone valerate using lecithin/chitosan nanoparticles: in-vitro and in-vivo evaluations

Özcan¹,

Azizoğlu²,

Şenyiğit³

et al. 2013

IJN

Self Cite

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show abstract

“…The combination of nanostructured therapeutic agents in NPs with dosage forms is yet a new and little-explored alternative for delivering NPs [111]. These NPs can be incorporated into dosage forms such as creams [112,113] ointments and hydrogels [114,115], patches [113,116] for topical penetration [115,117,118].…”

Section: Nanoparticles For Therapeutic Agent Deliverymentioning

confidence: 99%

Nanotechnology approaches in the current therapy of skin cancer

Borgheti-Cardoso

Viegas

Silvestrini

et al. 2020

Advanced Drug Delivery Reviews

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Skin cancer is a high burden disease with a high impact on global health. Conventional therapies have several drawbacks; thus, the development of effective therapies is required. In this context, nanotechnology approaches are an attractive strategy for cancer therapy because they enable the efficient delivery of drugs and other bioactive molecules to target tissues with low toxic effects. In this review, nanotechnological tools for skin cancer will be summarized and discussed. First, pathology and conventional therapies will be presented, followed by the challenges of skin cancer therapy. Then, the main features of developing efficient nanosystems will be discussed, and next, the most commonly used nanoparticles (NPs) described in the literature for skin cancer therapy will be presented. Subsequently, the use of NPs to deliver chemotherapeutics, immune and vaccine molecules and nucleic acids will be reviewed and discussed as will the combination of physical methods and NPs. Finally, multifunctional delivery systems to codeliver anticancer therapeutic agents containing or not surface functionalization will be summarized.

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“…DFV is a highly potent topical corticosteroid; however, in the classification of topical corticosteroids, potency is linked to side effects. Therefore, DFV as a high potent corticosteroid, has many side effects (Senyigit et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Effective topical delivery systems for corticosteroids: dermatological and histological evaluations

et al. 2014

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Atopic dermatitis (AD) is a chronic and relapsing skin disease with severe eczematous lesions. Long-term topical corticosteroid treatment can induce skin atrophy, hypopigmentation and transepidermal water loss (TEWL) increase. A new treatment approach was needed to reduce the risk by dermal targeting. For this purpose, Betamethasone valerate (BMV)/Diflucortolone valerate (DFV)-loaded liposomes (220-350 nm) were prepared and incorporated into chitosan gel to obtain adequate viscosity ($13 000 cps). Drugs were localized in stratum corneum + epidermis of rat skin in ex-vivo permeation studies. The toxicity was assessed on human fibroblast cells. In point of in-vivo studies, pharmacodynamic responses, treatment efficacy and skin irritation were evaluated and compared with previously prepared nanoparticles. Liposome/ nanoparticle in gel formulations produced higher paw edema inhibition in rats with respect to the commercial cream. Similar skin blanching effect with commercial creams was obtained via liposome in gels although they contain 10 times less drug. Dermatological scoring results, prognostic histological parameters and suppression of mast cell numbers showed higher treatment efficiency of liposome/nanoparticle in gel formulations in AD-induced rats. TEWL and erythema measurements confirmed these results. Overview of obtained results showed that liposomes might be an effective and safe carrier for corticosteroids in skin disease treatment.

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Innovative Topical Formulations for Treatment of Dermatitis

Cited by 6 publications

References 109 publications

Enhanced dermal delivery of diflucortolone valerate using lecithin/chitosan nanoparticles: in-vitro and in-vivo evaluations

Enhanced dermal delivery of diflucortolone valerate using lecithin/chitosan nanoparticles: in-vitro and in-vivo evaluations

Nanotechnology approaches in the current therapy of skin cancer

Effective topical delivery systems for corticosteroids: dermatological and histological evaluations

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