Inorganic-based biomaterials for rapid hemostasis and wound healing

Yi, Zheng; Wu, Jinfu; Zhu, Yufang; Wu, Chengtie

doi:10.1039/d2sc04962g

Cited by 49 publications

(22 citation statements)

References 265 publications

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“…Enhancing the biocompatibility material is crucial to mitigate any discrepancies in the mechanical properties and functional characteristics. This compatibility is particularly vital in the construction of wastewater treatment filtration systems intended for human consumption. , Mechanical capability improvement is also a major issue to tackle, primarily due to poor interlayer bonding, which subsequently restricts their applicability. Recent advancements have addressed these challenges through the development of a novel class of 3D-printed zeolite–polymer composites.…”

Section: A Brief Overview Of Zeolite–polymer Composites Using 3d Prin...mentioning

confidence: 99%

Deployable and Retrievable 3D-Printed Zeolite–Polymer Composites for Wastewater Treatment: A Review

Setiawan,

Alvin Setiadi,

Mukti

2023

Ind. Eng. Chem. Res.

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The development of shape-optimized adsorbent materials has garnered significant scientific interest in light of escalating environmental challenges and limitations of conventional materials. Addressing the issues of single-use materials is crucial to advancing adsorbent technologies. Recently, 3D-printed zeolite-polymer composites have emerged as versatile and promising adsorbent materials, offering deployability, retrievability, thermal stability, and cyclic regeneration capabilities. The synergistic combination of zeolite-composite formulations and 3D printing technology represents a promising approach for fabricating the perfect adsorbent for water treatment. This comprehensive review critically examines recent advancements in the realm of 3D printing technology to shape zeolite–polymer composites, specifically for water treatment applications. The facile fabrication of 3D-printed zeolite structures, accomplished by shaping zeolite within an ink solution and employing a printing process, enables the production of materials featuring macroporous, mesoporous, and microporous systems. These advancements hold significant promise for the design and implementation of highly efficient adsorbent materials for water treatment processes.

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Section: A Brief Overview Of Zeolite–polymer Composites Using 3d Prin...mentioning

confidence: 99%

Deployable and Retrievable 3D-Printed Zeolite–Polymer Composites for Wastewater Treatment: A Review

Setiawan,

Alvin Setiadi,

Mukti

2023

Ind. Eng. Chem. Res.

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“…When minor bleeding is caused by injury to the body, it can be stopped by a complex physiological process, 5 but control of severe uncontrolled traumatic bleeding is very challenging 6–10 . In the face of the risks posed by haemorrhage, timely and effective control of haemorrhage is a necessity 11–14 . Usually, haemostasis is the process of stopping bleeding through the formation of a blood clot, 15,16 the mechanism of which consists of two main stages, 17 as demonstrated in Figure 1.…”

Section: Introductionmentioning

confidence: 99%

State of the art, trends, hotspots, and prospects of injection materials for controlling bleeding

Feng,

Yang

2024

International Wound Journal

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Traumatic haemorrhage is a prevalent clinical condition, and effective and timely haemostasis is crucial for the preservation of patients' lives. In recent years, injectable hemostatic materials have gained significant attention due to their excellent hemostatic efficacy, biocompatibility, and biodegradability, making them widely applied in the treatment of incompressible traumatic haemorrhage. Systematic analysis of injectable hemostatic materials is crucial for research in this area. This article provides a comprehensive review of the development and research trends of injectable hemostatic materials over the past 20 years using visualization techniques. Analysis of collaboration and co‐citation networks revealed localized research collaboration networks, highlighting the need for enhanced international collaboration in the field of injectable hemostatic materials. Current research focuses primarily on hemostatic materials, hemostatic processes, and hemostatic mechanisms. Injectable hemostatic materials with excellent performance offer promising strategies for wound healing. This review provides a comprehensive and systematic summary of injectable hemostatic materials, offering valuable guidance for the development and clinical application of novel injectable hemostatic materials. Additionally, visualized methodology and mapping analysis are effective data mining methods that provide approaches and strategies for clear knowledge network analysis. These methods facilitate better understanding and interpretation of research dynamics in the field of injectable hemostatic materials, thereby guiding and inspiring future research.

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“…Uncontrolled bleeding, especially fatal hemorrhage, is a leading cause of mortality in military injuries and other traumas universally. 1,2 In some cases, it can be stopped by using pressure dressings or a tourniquet at the injury site. 3 However, for noncompressible fatal hemorrhage, there is no effective approach to deal with it, especially on a battlefield or in emergencies.…”

Section: Introductionmentioning

confidence: 99%

Self-Oxidated Hydrophilic Chitosan Fibrous Mats for Fatal Hemorrhage Control

Shi,

Dong

et al. 2024

ACS Appl. Mater. Interfaces

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Enriching erythrocytes and platelets in seconds and providing a fast seal in bleeding sites is vital to fatal hemorrhage control. Herein, hydrophilic chitosan fibrous mats (CECS-D mats) are fabricated by introducing hydrophilic carboxyethyl groups and subsequent catechol groups onto chitosan fibers. Due to strong hydrophilicity, CECS-D mats exhibit rapid liquid-absorption capacity, especially instantaneous absorptivity to the rabbit blood, which can achieve erythrocyte and platelet aggregations quickly by concentrating blood, thus promoting the formation of blood clots. Furthermore, the mats are self-oxidated to form quinone-amine adducts or quinone multimers by adjusting pH conditions, which not only provides tissue adhesion but also induces erythrocyte aggregation and platelet adhesion, further enhancing the seal and triggering quick closure to achieve fast hemostasis. Therefore, the mats reveal superior hemostatic performance in rabbit liver and spleen models over CECS mats and gauze. Especially in the fatal femoral artery injury model of rabbits, the mats reduce the blood loss by ∼75% and shortened the bleeding time by ∼50% compared with CECS mats, which have been reported to have the same hemostatic effect as commercialized Celox products in a swine femoral artery injury model. Besides, the mats are cytocompatible and degradable as well as antibacterial. This chitosan mat is a promising hemostatic material for fatal hemorrhage control.

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Inorganic-based biomaterials for rapid hemostasis and wound healing

Abstract: This review provides the recent progress in the application of inorganic-based biomaterials for rapid hemostasis and wound healing, including preparation methods, material systems, intrinsic mechanisms and biofunctions.

Cited by 49 publications

References 265 publications

Deployable and Retrievable 3D-Printed Zeolite–Polymer Composites for Wastewater Treatment: A Review

Deployable and Retrievable 3D-Printed Zeolite–Polymer Composites for Wastewater Treatment: A Review

State of the art, trends, hotspots, and prospects of injection materials for controlling bleeding

Self-Oxidated Hydrophilic Chitosan Fibrous Mats for Fatal Hemorrhage Control

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