Inorganic layered double hydroxides as ascorbic acid (vitamin C) delivery system—Intercalation and their controlled release properties

Gasser, M.S.

doi:10.1016/j.colsurfb.2009.05.005

Cited by 94 publications

(44 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These groups can interact with the positively charged brucite-like layer. The LDHs (LDH2-NO 3 , LDH2-Cl, and LDH3-CO 3 ) were added to a solution of one of the drugs in water or methanol (MeOH), and reactions were performed at different drug concentrations, temperatures, and times.…”

Section: Resultsmentioning

confidence: 99%

“…Nateglinide was intercalated rapidly into LDH; its uptake amount became saturated at 3 h. Optimal reaction conditions for intercalation of nateglinide were 20 mM nateglinide concentration in MeOH, 50°C, and 24 h. Although the intercalation reaction also was performed using ethanol, the reaction occurred more readily in methanol. A previous report indicated that carbonate ion (CO 3 2− ) in LDH3-CO 3 was released as HCO 3 − by abstracting a proton from methanol (MeOH). 21) Because the pK a of MeOH and ethanol (EtOH) is very similar (15.5 and 16, respectively), the effect of a proton on reactivity is likely to be small.…”

Section: Resultsmentioning

confidence: 99%

“…[1][2][3] For example, complexation with LDH improved the thermostability of 5-fluorouracil. 4) Additionally, LDH complexed with methotrexate, an anticancer drug, provided a lower IC 50 value compared to methotrexate alone because the LDH nanoparticles were internalized in cells via endocytosis, enhancing cellular uptake efficiency.…”

mentioning

confidence: 99%

“…It opens the application of biocompatible hydrotalcite. 3 2− during synthesis. 20) Other reagents, obtained from Wako Pure Chemical Industries, Ltd. (Osaka, Japan), were used without further purification.…”

mentioning

confidence: 99%

See 3 more Smart Citations

Complex Formation with Layered Double Hydroxides for the Remediation of Hygroscopicity

2015

View full text Add to dashboard Cite

Layered double hydroxides (LDHs) have been used commercially as antacids, to stabilize drugs, to allow the controlled release of incorporated drugs, and to act as drug carriers to reduce drug accumulation within the body. Several types of LDH were investigated: nitrate type (LDH-NO 3 ); chloride type (LDH-Cl); and carbonate type (LDH-CO 3 ). Each type was added to an aqueous or methanol (MeOH) solution containing a drug (pravastatin or nateglinide). With pravastatin sodium, the interlayer distance expanded after reaction with LDH-NO 3 and LDH-Cl in aqueous solution. In contrast, the interlayer distance of LDH-CO 3 increased in methanol with nateglinide. Each drug was intercalated into the interlayer space of LDH by ion exchange. The hygroscopicity of the drug substances, complexes, and physical mixtures were determined at 70% relative humidity. Increases in weight (%) of the complexes were less than those of the physical mixtures, which demonstrates that hygroscopicity was reduced upon complexation with LDH due to the layer of LDH over the drugs.Key words layered double hydroxide; hygroscopicity; drug Layered double hydroxides (LDHs) have been used as matrices for drug delivery systems and as coating materials to protect compounds against external influences such as light and humidity.1-3) For example, complexation with LDH improved the thermostability of 5-fluorouracil.4) Additionally, LDH complexed with methotrexate, an anticancer drug, provided a lower IC 50 value compared to methotrexate alone because the LDH nanoparticles were internalized in cells via endocytosis, enhancing cellular uptake efficiency.5) Thus, LDHs have high biological affinity and low cytotoxicity. Hydrotalcite, which is used as an antacid, is a type of LDH with anionic-exchange properties. 6) LDH substances are composed of a positively charged brucite-like octahedral layer and an interlayer anion. 7,8) The brucite-like layer consists of octahedrons with 2 or 3 positively charged metal ions. Therefore, LDHs with different characteristics (e.g., varying charge density, interlayer anions, and particle size) can be synthesized at low cost. Compared to montmorillonite and smectite, the layer charge density of LDH is large, and the interaction between the LDH layer and the interlayer anion is strong. The interlayer distance (d) is the thickness of one layer plus the distance of the interlayer space. An increase in d indicates that the interlayer anions can be exchanged with other anions (i.e., intercalation). Three intercalation methods are effective for LDHs: ion exchange, reconstruction, and coprecipitation. 9) All of these methods usually involve reaction in aqueous solution where the ease of intercalation is influenced by the interlayer anion, in the order of I ) in the interlayer region. However, the carbonate ion is the most stable in the interlayer space due to its high affinity for the layer.10) Therefore, decarbonation of LDH-CO 3 has been considered difficult, and LDH-CO 3 has been transformed to calcined-LDH by heating in an oven at ...

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Complex Formation with Layered Double Hydroxides for the Remediation of Hygroscopicity

2015

View full text Add to dashboard Cite

show abstract

“…The LDH, as a new drug carrier, are easily synthesized in the laboratory, have a high drug transportation efficiency, high drug loading density, low toxicity to target cells or organs and excellent protection to loaded molecules from undesired enzymatic degradation (Choi and Choy, 2011;Zhang et al, 2014). A plethora of drugs and bio-molecules have been reported to either attach to the surface of or intercalate into LDH materials through coprecipitation or anion-exchange reaction, including anti-inflammatory drugs (Rives et al, 2013), anticancer drugs (Choi et al, 2008), amino acid and peptides (Reinholdt and Kirkpatrick, 2006), nucleotides (Nakayama et al, 2010), vitamins (Gasser, 2009), and even polysaccharides (Yadollahi and Namazi, 2013;Yadollahi et al, 2014). Owing to their alkalinity, however, their use as orally available drug-delivery systems could be difficult.…”

Section: Introductionmentioning

confidence: 99%

Carboxymethyl cellulose capsulated layered double hydroxides/drug nanohybrids for Cephalexin oral delivery

Barkhordari

Yadollahi

2016

Applied Clay Science

View full text Add to dashboard Cite

Effect of attapulgite contents on release behaviors of a pH sensitive carboxymethyl cellulose‐g‐poly(acrylic acid)/attapulgite/sodium alginate composite hydrogel bead containing diclofenac

Wang

2011

J of Applied Polymer Sci

View full text Add to dashboard Cite

A series of pH-sensitive composite hydrogel beads, carboxymethyl cellulose-g-poly(acrylic acid)/attapulgite/sodium alginate (CMC-g-PAA/APT/SA), were prepared by combining CMC-g-PAA/APT composite and SA, using Ca 2þ as the ionic crosslinking agent and diclofenac sodium (DS) as the model drug. The effects of APT content and external pH on the swelling properties and release behaviors of DS from the composite hydrogel beads were investigated. The results showed that the composite hydrogel beads exhibited good pH-sensitivity. Introducing 20% APT into CMC-g-PAA hydrogel could change the surface structure of the composite hydrogel beads, decrease the swelling ability, and relieve the burst release effect of DS. The drug cumulative release ratio of DS from the hydrogel beads in simulated gastric fluid was only 3.71% within 3 hour, but in simulated intestinal fluid about 50% for 3 hour, 85% for 12 hour, up to 90% after 24 hour. The obtained results indicated that the CMC-g-PAA/APT/SA hydrogel beads could be applied to the drug delivery system as drug carriers in the intestinal tract.

show abstract

Inorganic layered double hydroxides as ascorbic acid (vitamin C) delivery system—Intercalation and their controlled release properties

Cited by 94 publications

References 24 publications

Complex Formation with Layered Double Hydroxides for the Remediation of Hygroscopicity

Complex Formation with Layered Double Hydroxides for the Remediation of Hygroscopicity

Carboxymethyl cellulose capsulated layered double hydroxides/drug nanohybrids for Cephalexin oral delivery

Effect of attapulgite contents on release behaviors of a pH sensitive carboxymethyl cellulose‐g‐poly(acrylic acid)/attapulgite/sodium alginate composite hydrogel bead containing diclofenac

Contact Info

Product

Resources

About