Inorganic nano-carriers based smart drug delivery systems for tumor therapy

Shi, Zhaoqing; Zhou, Yun; Fan, Taojian; Lin, Yao‐Xin; Zhang, Han; Mei, Lin

doi:10.1016/j.smaim.2020.05.002

Cited by 191 publications

(107 citation statements)

References 105 publications

Supporting

Mentioning

105

Contrasting

Unclassified

Order By: Relevance

“…As far as in situ applications are concerned, controlled release nano-delivery systems could be used to maintain the bFGF concentration. [49][50][51] In multi-lineage differentiation studies, notably, to eliminate the disturbance from growth factors, we adopted chemical-induction protocols to assess neurogenic differentiation ability of the succeeding passage from bFGF pre-treated DPSCs. 34 We found that supplement with bFGF did not compromise the pluripotency of DPSCs to differentiate into neurons, osteoblasts and adipocytes ( Figures 5 and 6).…”

Section: Discussionmentioning

confidence: 99%

Effects and mechanisms of basic fibroblast growth factor on the proliferation and regenerative profiles of cryopreserved dental pulp stem cells

et al. 2020

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Effects and mechanisms of basic fibroblast growth factor on the proliferation and regenerative profiles of cryopreserved dental pulp stem cells

et al. 2020

View full text Add to dashboard Cite

show abstract

“…A maximum drug loading of 13.4 % was achieved with up to 390 DOX molecules loaded in one nanoparticle. Recently, two‐dimensional black phosphorus nanomaterials are developed as a delivery platform, which can be used for high loading of theranostic agents as well as a co‐delivery system for gene/chemo/photothermal therapy . Additionally, numerous other materials such as calcium silicate hydrate, hydroxyapatite, magnesium silicate, and polypeptide have also been developed using similar post‐loading strategies to produce high drug‐loading nanoparticles with drug loadings from 26.1–69.6 % (Table ).…”

Section: Strategies For Fabricating High Drug‐loading Nanoparticlesmentioning

confidence: 99%

Development of High‐Drug‐Loading Nanoparticles

et al. 2020

View full text Add to dashboard Cite

research on developing nanoparticles with high drug loading (> 10 wt%) from the perspective of synthesis strategies, including post-loading, co-loading, and pre-loading. Based on these three different strategies, various nanoparticle systems with different materials and drugs are summarized and discussed in terms of their synthesis methods, drug loadings, encapsulation efficiencies, release profiles, stabilities, and their applications in drug delivery. The advantages and disadvantages of these strategies are presented with an objective of providing useful design rules for future development of high-drug-loading nanoparticles.

show abstract

“…Over the last two decades, the research attention on DDSs based on inorganic materials like mesoporous silica particles, gold nanoparticles, and graphene oxide [ 5 ] has seen rapid growth in the field of biomedicine, expanding in many directions. These materials were employed as carriers of anti-inflammatory agents [ 6 , 7 , 8 ], tumor diagnostic probes [ 9 , 10 ], as well as in biomedical imaging [ 11 , 12 ] and tissue engineering [ 13 , 14 , 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

PEG-Coated Large Mesoporous Silicas as Smart Platform for Protein Delivery and Their Use in a Collagen-Based Formulation for 3D Printing

Niclot

Montalbano

Fiorilli

et al. 2021

IJMS

View full text Add to dashboard Cite

Silica-based mesoporous systems have gained great interest in drug delivery applications due to their excellent biocompatibility and high loading capability. However, these materials face challenges in terms of pore-size limitations since they are characterized by nanopores ranging between 6–8 nm and thus unsuitable to host large molecular weight molecules such as proteins, enzymes and growth factors (GFs). In this work, for an application in the field of bone regeneration, large-pore mesoporous silicas (LPMSs) were developed to vehicle large biomolecules and release them under a pH stimulus. Considering bone remodeling, the proposed pH-triggered mechanism aims to mimic the release of GFs encased in the bone matrix due to bone resorption by osteoclasts (OCs) and the associated pH drop. To this aim, LPMSs were prepared by using 1,3,5-trimethyl benzene (TMB) as a swelling agent and the synthesis solution was hydrothermally treated and the influence of different process temperatures and durations on the resulting mesostructure was investigated. The synthesized particles exhibited a cage-like mesoporous structure with accessible pores of diameter up to 23 nm. LPMSs produced at 140 °C for 24 h showed the best compromise in terms of specific surface area, pores size and shape and hence, were selected for further experiments. Horseradish peroxidase (HRP) was used as model protein to evaluate the ability of the LPMSs to adsorb and release large biomolecules. After HRP-loading, LPMSs were coated with a pH-responsive polymer, poly(ethylene glycol) (PEG), allowing the release of the incorporated biomolecules in response to a pH decrease, in an attempt to mimic GFs release in bone under the acidic pH generated by the resorption activity of OCs. The reported results proved that PEG-coated carriers released HRP more quickly in an acidic environment, due to the protonation of PEG at low pH that catalyzes polymer hydrolysis reaction. Our findings indicate that LPMSs could be used as carriers to deliver large biomolecules and prove the effectiveness of PEG as pH-responsive coating. Finally, as proof of concept, a collagen-based suspension was obtained by incorporating PEG-coated LPMS carriers into a type I collagen matrix with the aim of designing a hybrid formulation for 3D-printing of bone scaffolds.

show abstract

Inorganic nano-carriers based smart drug delivery systems for tumor therapy

Cited by 191 publications

References 105 publications

Effects and mechanisms of basic fibroblast growth factor on the proliferation and regenerative profiles of cryopreserved dental pulp stem cells

Effects and mechanisms of basic fibroblast growth factor on the proliferation and regenerative profiles of cryopreserved dental pulp stem cells

Development of High‐Drug‐Loading Nanoparticles

PEG-Coated Large Mesoporous Silicas as Smart Platform for Protein Delivery and Their Use in a Collagen-Based Formulation for 3D Printing

Contact Info

Product

Resources

About