Inorganic nano-drug delivery systems for crossing the blood–brain barrier: Advances and challenges

Neuronal maturation-dependent nano–neuro interaction and modulation

“…However, these strategies are plagued by non-discriminate entry of compounds into the brain, which could lead to cerebral toxicity. 25–27,56 While our results demonstrate necessary physicochemical properties of nanomaterials to achieve selective targeting of neurons required for efficient neuromodulation, further studies are needed to understand and control the transport of nanomaterials across the BBB.…”

“…15–23 Moreover, recent advances in the development of efficient strategies for the transport of nanomaterials across the blood–brain barrier (BBB) to the brain parenchyma, via either receptor-mediated endocytosis, physical disruption of the BBB or local delivery, have demonstrated tremendous potential in clinical translation of nanomaterial-assisted neuromodulation for neurotherapeutics. 24–27…”

Spherical nucleic acids: emerging amplifiers for therapeutic nanoplatforms

“…The blood–brain barrier is a highly regulated barrier that restricts the passive entry of exogenous substances into the central nervous system, 48,49 which has been a bottleneck for brain administration for a long time. SNAs can penetrate the brain and offer a potential new approach to addressing this challenge.…”

Recent advances in targeted drug delivery for the treatment of glioblastoma

“…Studies have shown that modifying hydrophilic groups such as polyethylene glycol and glycolipids on the surface of nanoparticles can reduce the interaction between particles and reticuloendothelial cells, prolong the plasma half-life of drugs, and increase drug concentrations in blood. 117 Furthermore, modified surfactants on the surface of nanoparticles, such as polybethanol ester and polysorbate, can enhance lipid flow in endothelial cells and facilitate the drug to cross the BBB. 118,119 Fang et al .…”