Inorganic nanoparticle-based advanced cancer therapies: Promising combination strategies

Amaldoss, Maria John Newton; Yang, Jialin; Koshy, Pramod; Unnikrishnan, Ashwin; Sorrell, Charles C.

doi:10.1016/j.drudis.2022.103386

Cited by 33 publications

(24 citation statements)

References 131 publications

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“…The α,β-unsaturated β-diketo moiety of curcumin is reported to be a strong chelating agent; it interacts with various metal ions [ 45 ]. Based on these advantageous interactions, developing inorganic-based nanoparticles, whose nanostructures provide important characteristics for increasing the effectiveness of cancer therapy, is key to curcumin delivery [ 21 ].…”

Section: Curcumin and Its Anticancer Effectsmentioning

confidence: 99%

“…These nanoparticles are more advantageous than those of an organic nature when it comes to their optimized physicochemical properties, which make a difference in cancer therapy [ 19 ]. They can successfully carry curcumin and show synergy with this natural compound in cancer therapy [ 20 , 21 , 22 ]. Although different literature reviews have addressed different nanostructures containing curcumin, there is still a lack of association between curcumin inorganic nanostructures’ physicochemical properties and their in vivo anticancer effects.…”

Section: Introductionmentioning

confidence: 99%

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Recent Trends in Curcumin-Containing Inorganic-Based Nanoparticles Intended for In Vivo Cancer Therapy

Dourado,

Miranda,

de Oliveira

et al. 2024

Pharmaceutics

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Curcumin is a natural compound that has been widely investigated thanks to its various biological properties, including antiproliferative. This molecule acts on different cancers such as lung, breast, pancreatic, colorectal, etc. However, the bioactive actions of curcumin have limitations when its physicochemical properties compromise its pharmacological potential. As a therapeutic strategy against cancer, curcumin has been associated with inorganic nanoparticles. These nanocarriers are capable of delivering curcumin and offering physicochemical properties that synergistically enhance anticancer properties. This review highlights the different types of curcumin-based inorganic nanoparticles and discusses their physicochemical properties and in vivo anticancer activity in different models of cancer.

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Section: Curcumin and Its Anticancer Effectsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Recent Trends in Curcumin-Containing Inorganic-Based Nanoparticles Intended for In Vivo Cancer Therapy

Dourado,

Miranda,

de Oliveira

et al. 2024

Pharmaceutics

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“…Compared with mesoporous silica with a smaller pore size (∼2 nm), mesoporous silica with a larger pore size can load nucleic acids more efficiently and effectively protect them from nuclease degradation [ 144 ]. Moreover, inorganic nanoparticles have a large specific surface area, good biocompatibility and degradability, easy preparation, convenient storage conditions, and good stability [ 145 , 146 ]. Therefore, inorganic nanoparticles have broad application prospects as delivery vectors for CRISPR/Cas9 applications.…”

Section: Biomaterials Vectors For Crispr/cas9 Deliverymentioning

confidence: 99%

Biomaterial-Based CRISPR/Cas9 Delivery Systems for Tumor Treatment

Li,

Chen,

Yang

et al. 2024

Biomater Res

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CRISPR/Cas9 gene editing technology is characterized by high specificity and efficiency, and has been applied to the treatment of human diseases, especially tumors involving multiple genetic modifications. However, the clinical application of CRISPR/Cas9 still faces some major challenges, the most urgent of which is the development of optimized delivery vectors. Biomaterials are currently the best choice for use in CRISPR/Cas9 delivery vectors owing to their tunability, biocompatibility, and efficiency. As research on biomaterial vectors continues to progress, hope for the application of the CRISPR/Cas9 system for clinical oncology therapy builds. In this review, we first detail the CRISPR/Cas9 system and its potential applications in tumor therapy. Then, we introduce the different delivery forms and compare the physical, viral, and non-viral vectors. In addition, we analyze the characteristics of different types of biomaterial vectors. We further review recent research progress in the use of biomaterials as vectors for CRISPR/Cas9 delivery to treat specific tumors. Finally, we summarize the shortcomings and prospects of biomaterial-based CRISPR/Cas9 delivery systems.

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“…For example, ncRNAs encapsulated in cationic NPs (especially cationic liposomes) tend to show increased uptake from target cells due to the fact that such NPs easily interact with the negatively charged surface of the cell membrane (Silva-Cazares et al, 2020;Sukocheva et al, 2022); otherwise, the negative charge and molecular weight of miRNAs would hinder their passage across the cell membrane (Segal and Slack, 2020). Cell uptake of the nanocarrier can also be facilitated by coating it with tumor-specific targeting ligands, which in turn can reduce undesired off-target effects of miRNA mimics or antagomirs on healthy cells (Amaldoss et al, 2022;Kara et al, 2022).…”

Section: Advantages Of Nanotechnologymediated Mirna-based Drug Delive...mentioning

confidence: 99%

Applications of nanotechnologies for miRNA-based cancer therapeutics: current advances and future perspectives

Bravo-Vázquez,

Méndez-García,

Rodríguez

et al. 2023

Front. Bioeng. Biotechnol.

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MicroRNAs (miRNAs) are short (18–25 nt), non-coding, widely conserved RNA molecules responsible for regulating gene expression via sequence-specific post-transcriptional mechanisms. Since the human miRNA transcriptome regulates the expression of a number of tumor suppressors and oncogenes, its dysregulation is associated with the clinical onset of different types of cancer. Despite the fact that numerous therapeutic approaches have been designed in recent years to treat cancer, the complexity of the disease manifested by each patient has prevented the development of a highly effective disease management strategy. However, over the past decade, artificial miRNAs (i.e., anti-miRNAs and miRNA mimics) have shown promising results against various cancer types; nevertheless, their targeted delivery could be challenging. Notably, numerous reports have shown that nanotechnology-based delivery of miRNAs can greatly contribute to hindering cancer initiation and development processes, representing an innovative disease-modifying strategy against cancer. Hence, in this review, we evaluate recently developed nanotechnology-based miRNA drug delivery systems for cancer therapeutics and discuss the potential challenges and future directions, such as the promising use of plant-made nanoparticles, phytochemical-mediated modulation of miRNAs, and nanozymes.

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Inorganic nanoparticle-based advanced cancer therapies: Promising combination strategies

Cited by 33 publications

References 131 publications

Recent Trends in Curcumin-Containing Inorganic-Based Nanoparticles Intended for In Vivo Cancer Therapy

Recent Trends in Curcumin-Containing Inorganic-Based Nanoparticles Intended for In Vivo Cancer Therapy

Biomaterial-Based CRISPR/Cas9 Delivery Systems for Tumor Treatment

Applications of nanotechnologies for miRNA-based cancer therapeutics: current advances and future perspectives

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