Inorganic-Organic Hybrid Nanomaterials for Therapeutic and Diagnostic Imaging Applications

Vivero‐Escoto, Juan L.; Huang, Yan‐Hua

doi:10.3390/ijms12063888

Cited by 87 publications

(46 citation statements)

References 242 publications

(277 reference statements)

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“…[27][28][29] These properties provide MSNs high capacity to host different guest molecules and make them quite easy to be functionalized on their external or internal surface. Functional groups, polymers or nanoparticles could act as the "gatekeeper" for the mesopores, such as iron oxide nanoparticles, gold nanoparticles, stumili-responsive polymers, protein, dentrimers and cyclodextrin.…”

Section: Introductionmentioning

confidence: 99%

Light- and pH-activated intracellular drug release from polymeric mesoporous silica nanoparticles

Tian

Kong

et al. 2015

Colloids and Surfaces B: Biointerfaces

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Section: Introductionmentioning

confidence: 99%

Light- and pH-activated intracellular drug release from polymeric mesoporous silica nanoparticles

Tian

Kong

et al. 2015

Colloids and Surfaces B: Biointerfaces

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“…In particular, IONP/polymer nanoparticle exhibit a great potential for temperature-responsive drug delivery in various disease models. 33 Also, hybrid quantum dot-liposome nanoparticles have shown minimal toxicity and excellent tumor uptake in cancer models. 34 Hence, the observation of ABC phenomenon with RGO-IONP-PEG may provide valuable insight into the development and clinical translation of other hybrid nanoparticles.…”

Section: Resultsmentioning

confidence: 99%

Accelerated Blood Clearance Phenomenon Reduces the Passive Targeting of PEGylated Nanoparticles in Peripheral Arterial Disease

England

Feng

et al. 2016

ACS Appl. Mater. Interfaces

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Peripheral arterial disease (PAD) is a leading global health concern. Due to limited imaging and therapeutic options, PAD and other ischemia-related diseases may benefit from the use of long circulating nanoparticles as imaging probes and/or drug delivery vehicles. Polyethylene glycol (PEG)-conjugated nanoparticles have shown shortened circulation half-lives in vivo when injected multiple times into a single subject. This phenomenon has become known as the accelerated blood clearance (ABC) effect. The phenomenon is of concern for clinical translation of nanomaterials as it limits the passive accumulation of nanoparticles in many diseases, yet it has not been evaluated using inorganic or organic-inorganic hybrid nanoparticles. Herein, we found that the ABC phenomenon was induced by re-injection of PEGylated long circulating organic-inorganic hybrid nanoparticles, which significantly reduced the passive targeting of 64Cu-labeled PEGylated reduced graphene oxide – iron oxide nanoparticles (64Cu-RGO-IONP-PEG) in a murine model of PAD. Positron emission tomography (PET) imaging was performed at 3, 10, and 17 days post-surgical induction of hindlimb ischemia. At Day 3 post-surgery, the nanoparticles displayed a long circulation half-life with enhanced accumulation in the ischemic hindlimb. At Day 10 and 17 post-surgery, re-injected mice displayed a short circulation half-life and lower accumulation of the nanoparticles in the ischemic hindlimb, in comparison to the naïve group. Also, re-injected mice showed significantly higher liver uptake than the naïve group, indicating that the nanoparticles experienced higher sequestration by the liver in the re-injected group. Furthermore, photoacoustic (PA) imaging and Prussian blue staining confirmed the enhanced accumulation of the nanoparticles in the liver tissue of re-injected mice. These findings validate the ABC phenomenon using long circulating organic-inorganic hybrid nanoparticles upon multiple administrations to the same animal, which may provide valuable insight into the future clinical applications of nanoparticles for imaging and treatment of PAD.

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“…34 Thus, inorganic silica coating on Mel NPs is strongly considered for enhancing biocompatibility, surface functionality, and aqueous dispersity for biomedical applications. 35,36 …”

Section: Introductionmentioning

confidence: 99%

Silica-Coated Metal Chelating-Melanin Nanoparticles as a Dual-Modal Contrast Enhancement Imaging and Therapeutic Agent

Cho

Park

Kim

2016

ACS Appl. Mater. Interfaces

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Bioinspired melanin nanoparticle (Mel NP) synthesized with dopamine has been of great interest in various biomedical applications. However, the utilization of fascinating characters of Mel NP such as innate MR contrast effects, high affinity to metal ions, strong light absorption requires special design with strategic synthetic method for its own purpose. Here, we have introduced paramagnetic Gd3+ metal ions and silica nanocoating on Mel NP for the dual-modal MRI/fluorescent contrast-enhanced imaging and therapeutics. The Gd3+ chelating kinetics of Mel NP by quinone and hydroquinone residues were optimized in various conditions of Gd3+ amounts and pH in solution for improving MRI contrast enhancing properties of the Mel NP. Then, bioinert silica was coated on the surfaces of Gd-chelated Mel NP (Gd-Mel@SiO2 NP) with a modified sol–gel process. The silica nanocoating allowed increased outer sphere water diffusion time, resulting a significantly brighter MR T1 contrast effect of Gd-Mel@SiO2 NP, comparing with a bare Gd-Mel NP or clinical grade T1 contrast agent. Further, when the Gd-Mel@SiO2 NP was labeled with fluorescent molecules, a significantly enhanced fluorescent intensity was achieved by the silica nanocoating that preventing the innate fluorescent deactivation property of melanin. Finally, in vitro/in vivo dual-modal contrast enhanced MRI/fluorescent imaging and feasibility of image-guided cancer therapeutic applications using Gd-Mel@SiO2 NPs were successfully evaluated in a clinically relevant human prostate cancer xenograft mouse model.

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Inorganic-Organic Hybrid Nanomaterials for Therapeutic and Diagnostic Imaging Applications

Cited by 87 publications

References 242 publications

Light- and pH-activated intracellular drug release from polymeric mesoporous silica nanoparticles

Light- and pH-activated intracellular drug release from polymeric mesoporous silica nanoparticles

Accelerated Blood Clearance Phenomenon Reduces the Passive Targeting of PEGylated Nanoparticles in Peripheral Arterial Disease

Silica-Coated Metal Chelating-Melanin Nanoparticles as a Dual-Modal Contrast Enhancement Imaging and Therapeutic Agent

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