Inorganic–Organic Hybrid Nanoparticles with Biocompatible Calcium Phosphate Thin Shells for Fluorescence Enhancement

Abstract

Polymeric micelles consisting of asymmetric triblock copolymers were successfully used for fabrication of robust hybrid nanoparticles with highly biocompatible calcium phosphate shells. The hydrophobic polystyrene core encapsulates hydrophobic fluorescent dyes such as Nile red. The anionic polyacrylic acid provides the site for the mineralization reaction of calcium phosphate. The polyethylene glycol corona stabilizes the hybrid nanoparticles. Fluorescent dyes can be used as imaging agents for determining the location of the nanoparticles and to give an observable indication of drug delivery, while the calcium phosphate shell can enhance the fluorescence of the encapsulated dye.

Inhibition of osteoclastogenesis through siRNA delivery with tunable mesoporous bioactive nanocarriers

“…Among different types of nanocarriers [47][48][49][50][51], mesoporous silica nanoparticles (MSN) have great potential to deliver signaling molecules, including siRNA. Their unique properties, including a large surface area, tunable pore size, surface functionality, loading capacity, and biocompatibility, have motivated extensive study for their delivery of genetic molecules, including pDNA and siRNA [52,53].…”

Synthesis and characterization of ultralong nanofibrillar and hydroxyapatite powder

“…e l s e v i e r . c o m / l o c a t e / a p t micelle template [25,26]. Moreover, because the nucleation of the inorganic nanocrystals results from the combination of the specific functional sites of the organic agents with their inorganic counterparts in the reaction system, the organic molecules are selectively adhered to a certain facets of nanocrystals, which effectively prevents the agglomeration of the particles and endows the stability of the resulting nanocrystals.…”

“…4. The stretching vibration of the hydroxyl group band of HAp is assigned to 3734 and 650 cm À1 originating from libration bands of OH group, while the broadband at 3612 cm À1 is attributed to the absorbed water [26]. In HAp crystal structure, OH group are filled in a triangular channels along c direction.…”

Calcium Phosphate‐Reinforced Photosensitizer‐Loaded Polymer Nanoparticles for Photodynamic Therapy

“…[17][18][19][20][21] By using a mineralization approach, we have demonstrated the enhanced tumor specificity and therapeutic efficacy of CaP-mineralized doxorubicin-loaded polymer micelles. CaP minerals were observed to strongly hold its structure as assembled nanoparticles in blood (pH 7.4), whereas CaP dissolved as non-toxic calcium and phosphate ions in acidic cellular endosomes (pH~5.0) and lysosomes (pH~4.5) to trigger the release of doxorubicin.…”