Synthesis and characterization of ultralong nanofibrillar and hydroxyapatite powder

Liu, Huan; Huang, Jian; Feng, Yaomiao; Liu, Jie; Yu, Xibin

doi:10.1016/j.apt.2014.11.020

Cited by 9 publications

(1 citation statement)

References 25 publications

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“…NanoHAp powders make the sinterability easier and enhance densification due to an increased surface area:size ratio, which makes them ideal substitutes for natural bone [ 19 ]. Up to now, various wet chemical routes in aqueous or non-aqueous solution systems have been employed to synthesize nanostructured HAp [ 12 , 20 , 21 ], such as hydrothermal [ 22 , 23 ], chemical precipitation [ 24 , 25 ], wet chemical [ 26 , 27 ], and sol–gel methods [ 28 , 29 ].…”

Section: Introductionmentioning

confidence: 99%

Repair of the Orbital Wall Fractures in Rabbit Animal Model Using Nanostructured Hydroxyapatite-Based Implant

Gradinaru

Popescu²,

Piticescu³

et al. 2016

Nanomaterials

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Cellular uptake and cytotoxicity of nanostructured hydroxyapatite (nanoHAp) are dependent on its physical parameters. Therefore, an understanding of both surface chemistry and morphology of nanoHAp is needed in order to be able to anticipate its in vivo behavior. The aim of this paper is to characterize an engineered nanoHAp in terms of physico-chemical properties, biocompatibility, and its capability to reconstitute the orbital wall fractures in rabbits. NanoHAp was synthesized using a high pressure hydrothermal method and characterized by physico-chemical, structural, morphological, and optical techniques. X-ray diffraction revealed HAp crystallites of 21 nm, while Scanning Electron Microscopy (SEM) images showed spherical shapes of HAp powder. Mean particle size of HAp measured by DLS technique was 146.3 nm. Biocompatibility was estimated by the effect of HAp powder on the adhesion and proliferation of mesenchymal stem cells (MSC) in culture. The results showed that cell proliferation on powder-coated slides was between 73.4% and 98.3% of control cells (cells grown in normal culture conditions). Computed tomography analysis of the preformed nanoHAp implanted in orbital wall fractures, performed at one and two months postoperative, demonstrated the integration of the implants in the bones. In conclusion, our engineered nanoHAp is stable, biocompatible, and may be safely considered for reconstruction of orbital wall fractures.

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