Inorganic Pyrophosphate in Plasma, Urine, and Synovial Fluid of Patients With Pyrophosphate Arthropathy (Chondrocalcinosis or Pseudogout)

Russell, R. G. G.; Bisaz, S.; Fleisch, H.; Currey, H. L. F.; Rubinstein, Herbert M.; Dietz, Albert A.; Boussina, I; Micheli, A; Fallet, G H

doi:10.1016/s0140-6736(70)92070-2

Cited by 132 publications

(68 citation statements)

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“…Analysis of plasma PPi levels of 10 normal subjects, 10 patients with osteoarthritis, and 10 with CPPD deposition disease failed to reveal any significant intergroup difference in means or in the range of individual values. This contrasts with our previous report (3) of elevated levels in some patients with pseudogout and osteoarthritis but agrees with the studies of Russell et a1 (8) and Altman et a1 (2) who observed no such difference. The cause of elevated mean plasma PPi levels in our prior studies of patients with OA and CPPD deposition may be a result of diurnal variation in PPi.…”

Section: (U M)supporting

confidence: 78%

Quantification of human plasma inorganic pyrophosphate

Kozin

1979

Arthritis & Rheumatism

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The methodologic variables of the UDPG pyrophosphorylase method for analysis of inorganic pyre phosphate (PPi) levels in biologic fluids are described. Use of a tourniquet in collection of blood specimens elevated plasma PPi levels from 35% to 55% above control values and may explain the differences in published normal values. The sodium pyrophosphate decahydrate used to prepare the standard solution lost 8 waters of hydration after dessication, which could result in the calculation of spuriously elevated PPi levels. Normal plasma PPi concentration was 2.18 p M with a range (M% confidence limits) of 0.58-3.78 pM. Comparison of plasma PPi in normal subjects, patients with primary osteoarthritis, and patients with calcium pyrophosphate dihydrate deposition disease revealed no significant intergroup differences.Measurement of inorganic pyrophosphate (PPi) in plasma and other biologic fluids is important in studies of bone metabolism, renal stone disease, and certain types of arthritis. Previously described methods of PPi

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Section: (U M)supporting

confidence: 78%

Quantification of human plasma inorganic pyrophosphate

Kozin

1979

Arthritis & Rheumatism

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“…This may be related to the fact that high PPi level, the metabolic abnormality that predisposes to CPPD (the main constituent of CC), also inhibits hydroxyapatite crystal nucleation and growth (28)(29)(30), thereby resulting in less osteophytosis and failure to repair the damaged bone stock resulting in attrition. The finding of a negative association between hip CC and summated osteophyte scores in hips with OA is also consistent with this hypothesis.…”

Section: Discussionmentioning

confidence: 99%

Does Chondrocalcinosis Associate With a Distinct Radiographic Phenotype of Osteoarthritis in Knees and Hips? A Case–Control Study

Agarwal

Doherty

Maciewicz

et al. 2016

Arthritis Care & Research

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ObjectiveTo examine if knee chondrocalcinosis (CC), hip CC, or CC at distant joints associates with a distinct radiographic phenotype of osteoarthritis (OA) in knees or hips.MethodsWe conducted a case–control study using data from the Genetics of Osteoarthritis and Lifestyle (GOAL) study (n = 3,170). All participants of the GOAL study had radiographs of knees, hands, and pelvis, which have been scored for CC and for individual radiographic features of OA. For this study, cases had radiographic OA and CC, and controls had radiographic OA without CC at the index joint. Data for knees and hips were analyzed separately. Binary logistic regression was used to examine the association between each radiographic phenotype and CC in joints with OA. Generalized estimating equation analysis was used to account for correlated data.ResultsKnee CC, and CC at any distant joint (without knee CC), associated with attrition in knee OA (adjusted odds ratio 2.32 [95% confidence interval 1.42–3.79] and 2.42 [1.41–4.13], respectively). There was no association between knee CC and osteophytosis or joint space narrowing (JSN) in knees with OA. Hip CC associated negatively with the summated osteophyte score and minimum JSN in hip OA. However, in hips with OA, CC did not associate with cysts or sclerosis. Additionally, distant joint CC did not associate with any structural change in hip OA.ConclusionThis study demonstrates that knee CC and CC at distant joints associate with attrition in knee OA, and hip CC associates with a milder hip OA phenotype. There was no evidence that CC associates with a hypertrophic OA phenotype.

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“…Studies on synovial fluid alkaline phosphatase (SF-ALP) levels have been extensively reported in the literature, but only in calcium pyrophosphate crystal deposition disease (1)(2)(3). This is perhaps because a deficiency in pyrophosphatase activity was proposed as one of the possible causes of increased inorganic pyrophosphate concentrations.…”

Section: To the Editormentioning

confidence: 99%

“…In most previously reported cases of hypothenar hammer syndrome, ischemic changes in 1 or several of the second through fifth digits developed in the dominant hand of male manual laborers, with or without typical Raynaud's phenomenon (1,3,5,6). In a recent review on this subject, it was stated that no patient with hypothenar hammer syndrome developed the hyperemic phase of Raynaud's phenomenon, although pallor and cyanosis were common (1).…”

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confidence: 99%