Abstract:d-myo-Inositol
1,4,5-trisphosphate receptors
(IP3Rs) are Ca2+ channels activated by the intracellular
messenger inositol 1,4,5-trisphosphate (IP3, 1). The glyconucleotide adenophostin A (AdA, 2) is a
potent agonist of IP3Rs. A recent synthesis of d-chiro-inositol adenophostin (InsAdA, 5) employed suitably protected chiral building blocks and replaced
the d-glucose core by d-chiro-inositol.
An alternative approach to fully chiral material is now reported using
intrinsic sugar chirality to avoid early isomer res… Show more
“…191 A synthetic approach to an inositol-based adenophostin analogue, which involves the coupling of protected and activated racemic myo -inositol derivative to a d -ribose derivative, followed by diastereomer separation, was also reported and it has proven to be the most potent agonist of InsP 3 receptor to date. 192…”
Section: Isolation Structural Diversity and Pharmacological And Biolo...mentioning
The structural, biological, and pharmacological profiles of phosphorylated secondary metabolites is presented. An overview of the phosphorylation methodologies employed in their total syntheses is also included.
“…191 A synthetic approach to an inositol-based adenophostin analogue, which involves the coupling of protected and activated racemic myo -inositol derivative to a d -ribose derivative, followed by diastereomer separation, was also reported and it has proven to be the most potent agonist of InsP 3 receptor to date. 192…”
Section: Isolation Structural Diversity and Pharmacological And Biolo...mentioning
The structural, biological, and pharmacological profiles of phosphorylated secondary metabolites is presented. An overview of the phosphorylation methodologies employed in their total syntheses is also included.
“…24 MI is a member of the inositol family, which has also been called cyclitols and polyols. 25,26 It is a primary natural product that is abundant in nature. 27,28 MI is used in various cosmetics, biochemical, pharmaceutical, and nutritional processes etc.…”
A study of the micellar behavior of ([P666(14)][THPP]) with myo-inositol and aspirin/ibuprofen, using surface tension, conductivity, colorimetry, viscometry, DLS and FTIR, methods.
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