2017
DOI: 10.1080/19768354.2017.1408684
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Inositol pyrophosphates as multifaceted metabolites in the regulation of mammalian signaling networks

Abstract: Inositol pyrophosphates (PP-IPs) such as 5-diphosphoinositol pentakisphosphate (5-IP 7 ) are inositol metabolites with high-energy phosphoanhydride bonds. The formation of PP-IPs is catalyzed by two groups of enzymes, the IP6 kinases and the PPIP5 kinases, which both phosphorylate inositol hexakisphosphate (IP 6 ). In mammals, PP-IPs are implicated in diverse biological phenomena including cellular growth, vesicular trafficking, apoptosis, and metabolic homeostasis. Mechanistically, all the diverse actions of … Show more

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Cited by 12 publications
(12 citation statements)
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“…Among many IP species, pyrophosphorylated-IPs (PP-IPs) exhibit a unique structural feature in that they contain highly energetic phosphoanhydride bonds (pyrophosphates) at specific positions [10,11]. Their biosynthesis is catalyzed by two groups of IP kinases, the IP6 kinases (IP6Ks) [12,13] and the PPIP5 kinases (PPIP5Ks) [14,15], which phosphorylate IP6 and IP7.…”
Section: Biosynthesis Of Inositol Pyrophosphatesmentioning
confidence: 99%
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“…Among many IP species, pyrophosphorylated-IPs (PP-IPs) exhibit a unique structural feature in that they contain highly energetic phosphoanhydride bonds (pyrophosphates) at specific positions [10,11]. Their biosynthesis is catalyzed by two groups of IP kinases, the IP6 kinases (IP6Ks) [12,13] and the PPIP5 kinases (PPIP5Ks) [14,15], which phosphorylate IP6 and IP7.…”
Section: Biosynthesis Of Inositol Pyrophosphatesmentioning
confidence: 99%
“…In addition to IP7, cellular conditions such as osmolarity [14], temperature [26], and phosphate levels [27] are also known to increase IP8 levels. Because of their high-energy phosphate bonds and rapid cellular turnover in response to cellular stimuli, PP-IPs have been viewed as 'mammalian cell signals', 'regulators of cell homeostasis', and 'metabolic messengers' [9,11,[28][29][30].…”
Section: Biosynthesis Of Inositol Pyrophosphatesmentioning
confidence: 99%
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