1986
DOI: 10.1111/j.1476-5381.1986.tb10818.x
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Inotropic effects of Ca2+ channel agonist and antagonists in neuraminidase‐treated left atria of rats

Abstract: 1 The effects of removal of sialic acid from cardiac sarcolemma on contractile functions and on inotropic responses to Ca2" channel agonist and antagonists were investigated in rat left atria.2 About 64% ofthe total sialic acid content of the left atria was removed during a 90 min exposure to neuraminidase (2 u ml ').3 The removal of sialic acid neither affected the development of twitch tension induced by stimulation at a frequency of0.5 Hz, nor altered the interval-dependent changes in contractility such as … Show more

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